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Autor:
Gizem Celebi, Nuriye Nuray Ulusu, Duygu Aydemir, Fatma Kaya Dağıstanlı, Evrim Komurcu-Bayrak, Ayse Seda Akdemir, Merve Anapali, Turgut Ulutin
Publikováno v:
Pharmacological Reports. 74:124-134
Type 2 Diabetes Mellitus is a chronic metabolic disease that causes endothelial damage and is an important risk factor for atherosclerosis. In the present study vitamin D3 supplementation in rats was used to determine the role of Osteoprotegerin (OPG
Autor:
Bo Cheng, Zong-Chao Cui, Changju Zhu, Sanyang Chen, Yan-Na Liu, Yaodong Song, Yan Zhang, Zhongwei Wu
Publikováno v:
World Journal of Gastroenterology
Background Acute pancreatitis (AP) is an inflammatory disease in which the regulatory pathway is complex and not well understood. Soluble suppression of tumorigenicity 2 (sST2) protein receptor functions as a decoy receptor for interleukin (IL)-33 to
Autor:
Faiza Mumtaz, Amir Shadboorestan, Ahmad Reza Dehpour, Mahmoud Ghazi-Khansari, Alireza Abdollahi, Muhammad Imran Khan, Ghallab Alotaibi, Asma Rashki
Publikováno v:
Fundamental & Clinical Pharmacology. 36:250-261
Seizure occurs as a result of uncontrolled electrical disturbances within the brain. Various biomolecules such as N-methyl-D-aspartate (NMDA), nitric oxide (NO), and cAMP response element-binding protein (CREB) have been implicated in the pathophysio
Publikováno v:
SaBios-Revista de Saúde e Biologia. 16:1-14
Entre as mulheres, o câncer de mama é o mais comum e incidente tipo de tumor. Apesar dos avanços significativos no tratamento, permanecem lacunas em relação ao entendimento dos mecanismos de resistência às terapias. Os canabinoides têm demons
Autor:
Takaji Matsutani, Eiichi Ohtsuka, Yoshitaka Imaizumi, Kenji Ishitsuka, Asahi Ito, Makoto Yoshimitsu, Kentaro Yonekura, Ilseung Choi, Atae Utsunomiya, Kisato Nosaka, Nobuaki Nakano, Shinsuke Iida, Ryuzo Ueda, Michihiro Hidaka, Toshiro Kawakita, Takashi Ishida, Youko Suehiro, Junya Makiyama, Hiro Tatetsu, Hidenori Sasaki, Shigeru Kusumoto, Takeharu Kato, Tatsuro Jo, Masao Ogata
Publikováno v:
British Journal of Haematology. 196:629-638
'Monitoring of immune responses following mogamulizumab-containing treatment in patients with adult T-cell leukaemia-lymphoma (ATL)' (MIMOGA) is a multicentre prospective clinical study (UMIN000008696). In the MIMOGA study, we found that a lower perc
Autor:
Ethan J. Anderson, T. Blake Monroe
Publikováno v:
Chemical Research in Toxicology
Monoamine oxidase (MAO) is rapidly gaining appreciation for its pathophysiologic role in cardiac injury and failure. Oxidative deamination of norepinephrine by MAO generates H2O2 and the catecholaldehyde 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), t
Autor:
Viviana Casagrande, Massimo Federici, Germana Cocozza, Heike Wulff, Rossella Menghini, Marta Morotti, Marcello Raspa, Stefano Garofalo, Giuseppina Chece, Cristina Limatola, Alfonso Grimaldi, Ferdinando Scavizzi, Mario Lecce
Publikováno v:
British Journal of Pharmacology. 178:4891-4906
BACKGROUND AND PURPOSE Amyotrophic lateral sclerosis (ALS) patients exhibit dysfunctional energy metabolism and weight loss, which is negatively correlated with survival, together with neuroinflammation. However, the possible contribution of neuroinf
Publikováno v:
Biochemistry and Cell Biology. 99:666-674
Liver fibrosis is the most common pathway in most types of chronic liver damage, characterized by an imbalance of ECM degradation and synthesis. Saikosaponin-d (SSd) possesses anti-inflammatory and anti-fibrotic effects. However, the underlying mecha
Publikováno v:
Iranian Journal of Toxicology, Vol 15, Iss 4, Pp 241-248 (2021)
Background: Damages to the peripheral fibers of sensory nerve cells and central neurons cause neuropathic pain. Manifestations of neuropathic pain occur in various conditions, including diabetes mellitus, chemotherapy, and as the side effects of some
Autor:
Pa-thai Yenchitsomanus, Thawornchai Limjindaporn, Suchanoot Kutpruek, Kanchana Suksri, Namoiy Semprasert, Mutita Junking, Suwattanee Kooptiwut
Publikováno v:
Journal of Molecular Endocrinology. 67:95-106
Long-term medication with dexamethasone – a synthetic glucocorticoid (GC) drug – results in hyperglycemia, or steroid-induced diabetes. Although recent studies revealed that dexamethasone directly induces pancreatic β-cell apoptosis, its molecul