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Publikováno v:
Folia Morphologica. 81:931-941
Background: Adipose tissue-derived mesenchymal stem cells (AD-MSCs) were proved to differentiate into insulin-producing cells (IPCs), but the amount of insulin secreted was relatively low compared to the insulin secreted by mature pancreatic islets.
Publikováno v:
Nutr Neurosci
Diets high in saturated fat (HFD) disrupt dopamine neurotransmission, whereas fasting alters tonic and phasic dopamine release to drive motivation and food consumption. However, functional compartments in the nucleus accumbens (NAc) influencing these
Publikováno v:
Cannabis Cannabinoid Res
BACKGROUND: Beside others, neuroinhibitory and sedative effects of CBD were documented. AIM AND METHODS: The aim of the study was to assess the dose-related effects of CBD premedication on the course of isoflurane anesthesia. Wistar rats were pretrea
Autor:
Gulce Naz Yazici, Halis Suleyman, Ercument Keskin, Mehmet Gül, Abdullah Erdogan, Mukadder Sunar
Publikováno v:
Revista Internacional de Andrología. 20:S17-S23
This study aimed to biochemically and histopathologically investigate the effect of sunitinib on oxidative testicular damage induced by ischemia/reperfusion in rats.Experimental animals were divided into three groups of six rats each: testicular tors
Autor:
Sefa Sag, Kaan Masrabaci, Yagmur Sonmez, Selenay Furat Recber, Esmanur Seker, Yusufhan Yazir, Levent Elemen, Karolin Yanar, Seval Aydin
Publikováno v:
Journal of Pediatric Surgery. 57:457-462
Background Pathophysiology of appendicitis is associated with the underlying inflammatory processes. Ethyl pyruvate (EP) has potent antioxidant and anti-inflammatory properties. In this study, we aimed to investigate the effects of EP on the treatmen
Autor:
Fatima Rasool, Muhammad Irfan Siddique, Muhammad Farhan Sohail, Muhammad Sarfraz, Muhammad Nabeel Shahid, Muhammad Ovais Omer, Saima Tufail, Haliza Katas
Publikováno v:
Current Drug Delivery. 19:534-546
Introduction: The pleiotropic effects of statins are recently explored for wound healing through angiogenesis and lymph-angiogenesis that could be of great importance in diabetic wounds. Aim: The aim of the present study is to fabricate nanofilm embe
Publikováno v:
Neuroscience. 497:118-133
Systemic administration of drugs that activate the noradrenergic or glucocorticoid system potentiates aversive memory consolidation and reconsolidation. The opposite happens with the stimulation of endocannabinoid signaling under certain conditions.
Autor:
Mohamed Abouelkheir
Publikováno v:
Current Molecular Pharmacology. 15:582-588
Background: We previously tested two angiotensin-converting enzyme (ACE) inhibitors and two dipeptidyl peptidase-4 (DPP-4) inhibitors for dual enzyme inhibitory effect. Only two DPP-4 inhibitors, linagliptin and sitagliptin, were able to inhibit ACE.
Publikováno v:
Immunopharmacology and Immunotoxicology. 44:586-593
Background: Dexmedetomidine (DEX) has showed significant analgesic effects in neuropathic pain, but the underlying mechanism has remained elusive. Our present study aimed to explore the effect of DEX on hyperalgesia with the involvement of p38MAPK si
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 100:412-421
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including central obesity, hypertension, insulin resistance, dyslipidemia, and hyperglyemia. MetS is found to be a positive predictor of cardiovascular morbidity and mortality. The