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Autor:
Marissa Bernhofer, Erin Nixon, Sara Nogueiro, Mara McDermott, Robyn E. Reeve, Sydney Schneider, Kylie Noelle Perez, Marietta R. Easterling, Erica J. Crespi, Grace H. Curtis
Publikováno v:
Environmental Toxicology. 36:1447-1456
Permethrin is a commonly used, highly effective pesticide in poultry agriculture, and has recently been trialed in conservation efforts to protect Galápagos finch hatchlings from an invasive ectoparasite. Although permethrin is considered safe for a
Autor:
Guoqing Wan, Xuefeng Gu, Yingying Wang, Wenhui Huang, Nian-Hong Chen, Yuhan Bi, Yu Yang, Keshen Li
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 128:758-772
MiRNAs are small, non-coding RNAs that can silence the expression of various target genes by binding their mRNAs and thus regulate a wide range of crucial bodily functions. However, the miRNA expression profile of schizophrenia after antipsychotic me
Autor:
Gladys Chirino-Galindo, Leonardo-Elías Cabrera-Nájera, Liliana-Berenice Ramírez-Domínguez, Ana-María García-Bores, Edgar-Antonio Estrella-Parra, Martín Palomar-Morales, Ilse-Valeria López-Quintero
Publikováno v:
Birth Defects Research. 113:981-994
BACKGROUND The deleterious effects of diabetes mellitus (DM) over development are apparently due to an increase in oxidative stress. Some antioxidants could prevent developmental alterations produced by diabetic state. Extracts of plants of the genus
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 35:1-13
Cyclosporine-A (CsA) is a powerful immunosuppressive agent and hepatotoxicity results from CsA treatment. This study aimed to elucidate the effectiveness of tyrosine kinase inhibitor nilotinib against CsA-induced hepatotoxicity and the underlying mol
Publikováno v:
Environmental Toxicology. 36:1217-1225
Few studies have reported a prophylactic effect of the anti-ischemic trimetazidine (TRI) against cardiac toxicity caused by adriamycin (ADR). However, the mechanism of action of TRI remained incomplete. The cardioprotective mechanism(s) of TRI agains
Publikováno v:
Drug and Chemical Toxicology. 45:2024-2030
The aim of the present study was to investigate the therapeutic and protective effects of linalool against doxorubicin (DOX)-induced kidney injury. Forty-eight Wistar rats were divided into 8 groups as follows; Control, DOX [20 mg/kg, intraperitoneal
Publikováno v:
Human & Experimental Toxicology. 40:1422-1433
Purpose: Cerebral ischemia is the main cause of permanent adult disabilities worldwide. This study investigated the reparative effects and potential mechanisms of methylphenidate (MPH), a medication for the treatment of attention-deficit/hyperactivit
Publikováno v:
Reproductive Toxicology. 100:74-82
The panel of suitable reference genes in the fetal liver have not been reported. In this study, five commonly used reference genes (GAPDH, β-actin, Rn18 s, Rpl13a, and Rps29) were firstly selected as candidates. Bestkeeper, GeNorm, and NormFinder so
Publikováno v:
Toxicology Mechanisms and Methods. 31:367-373
Isoflurane inhalation can cause nerve damage, and miR-191 is abnormally expressed in nerve crush injuries. This study aimed to explore the effect of miR-191 on isoflurane-induced cognition impairment and neurotoxicity in vivo and in vitro, as well as
Autor:
Ali A. Shati, Attalla F. El-kott
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 128:805-821
This study investigated the nephroprotective role of acylated ghrelin (AG) against DOX-induced nephropathy and examined whether the protection involves silent information regulator 1 (SIRT1). Rats were divided into control, control + AG, DOX, DOX + A