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Publikováno v:
Biochemistry and Cell Biology. 100:28-36
Interleukin-1β, a key cytokine in gouty inflammation, is precisely regulated by the NLRP3 inflammasome and NF-κB. Our previous study demonstrated that paeonol suppressed IL-1β production in rats with monosodium urate (MSU)-induced arthritis. Wheth
Autor:
Zhe Wang, Bin Cheng, Jian-Min Lv, Shang-Rong Ji, Xiao-Ling Liu, Hai-Yun Li, Zhao-Ming Tang, Yi Wu, Yu-Lin Liang, Ning Gao
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 289-307 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background and aims C-reactive protein (CRP) is a hepatocyte-produced marker of inflammation yet with undefined function in liver injury. We aimed to examine the role of CRP in acetaminophen-induced liver injury (AILI). Methods The effects of CRP in
Autor:
Neha Rahuja, Harish Kumar, Hari Narayan Kushwaha, Bhawani Singh, A. K. Misra, Jyoti Gupta, Arvind K. Srivastava, Natasha Jaiswal, Ram Pratap, Anil Kumar Dwivedi, Dharmendra P Singh, Ishbal Ahmad, P. C. Verma, Rohit Srivastava, Anand P. Gupta, Akhilesh K. Tamrakar, Sabyasachi Sanyal, Sheo K. Singh, Varsha Gupta, Jiaur R. Gayen
Publikováno v:
Pharmacology. 107:54-68
Introduction: The present study deals with the synthesis of pregnane-oximino-amino-alkyl-ethers and their evaluation for antidiabetic and anti-dyslipidemic activities in validated animal and cell culture models. Methods: The effect on glucose toleran
Autor:
Tsutomu Suzuki, Hirokazu Mishima, Mika Kobayashi, Masahide Fujita, Yasuhide Morioka, Motoji Kitaura, Katsumi Koike, Kana Yasufuku, Shino Takenouchi, Hiroki Chiba, Minoru Hasegawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1746-1751
Tramadol is a weak opioid that produces analgesic effect via both the μ-opioid receptor (MOR) and non-opioid targets. Constipation is the most common opioid-related side effect in patients with cancer and non-cancer pain. However, the contribution o
Publikováno v:
Human & Experimental Toxicology. 40:S540-S552
Ischemic stroke is a leading cause of death and long-term disability worldwide. The aim of this study is to explore the potential function of ephedrine in ischemic stroke and the underlying molecular mechanism. A middle cerebral artery occlusion (MCA
Autor:
İbrahim Murat Özgüler, Latif Üstünel
Publikováno v:
Turkish Journal of Medical Sciences
Background/aim In this study, we aimed to investigate the effects of antioxidant iloprost (ILO) and ß3 adrenergic receptor agonist (BRL) on transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential canonical 1 (TRPC1) ion chann
Autor:
Ruth M López Mayorga, Elvia Mera Jiménez, Betzabel Rodríguez-Reyes, Cecilia Tufiño, Rosa Amalia Bobadilla Lugo
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:1026-1035
Insulin resistance is a feature of pregnancy and is associated with increased levels of angiotensin II (Ang II) and insulin. Therefore, pregnancy may change insulin-induced vasodilation through changes in Ang II receptors. Insulin-induced vasorelaxat
Publikováno v:
Immunopharmacology and Immunotoxicology. 43:758-766
Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) exposure might be considerably associated with a decreased risk of Alzheimer's disease (AD). Therefore, we conducted an experiment to investigate the impact of indomethacin (IND) on inflammaso
Publikováno v:
Journal of Molecular Neuroscience. 72:565-573
As one of the main types of secondary craniocerebral injury, the onset, progression, and prognosis of chronic subdural hematoma (CSDH) are closely related to the local inflammation of intracranial hematoma. Atorvastatin is reported to be effective in
Publikováno v:
Drug and Chemical Toxicology. 45:2568-2575
Gentamicin (GM) is an antibiotic belonging to an aminoglycoside family that might induce nephrotoxicity in human and animal models via oxidative stress. Toll-like receptors (TLRs) are part of innat...