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Autor:
Tracy M. Josephs, Le Vi Dinh, Aaron DeBono, Karen J. Gregory, Ben Capuano, Katie Leach, Andrew N. Keller
Publikováno v:
ChemMedChem. 16:3451-3462
The calcium-sensing receptor (CaSR) is a clinical target in the treatment of hyperparathyroidism and related diseases. However, clinical use of approved CaSR-targeting drugs such as cinacalcet ( 1 ) is limited due to adverse side effects including hy
Publikováno v:
European Journal of Pain. 25:2266-2277
BACKGROUND Exposure to stressful experiences is often accompanied by suppressing pain perception, referred to as stress-induced analgesia. The neuropeptides orexins are essential in regulating the mechanism that responds to stressful and painful stim
Autor:
Tomomi Matsuura, Takeshi Tobiume, Etsuko Uematsu, Tomoya Hara, Takayuki Ise, Shusuke Yagi, Tetsuzo Wakatsuki, Takeshi Soeki, Koji Yamaguchi, Daiju Fukuda, Kenya Kusunose, Masataka Sata, Hirotsugu Yamada
Publikováno v:
Circulation Journal. 85:1383-1391
Background Activated factor X (FXa), which contributes to chronic inflammation via protease-activated receptor 2 (PAR2), might play an important role in atrial fibrillation (AF) arrhythmogenesis. This study aimed to assess whether PAR2 signaling cont
Autor:
Masaki Ryuzaki, Asuka Uto, Hiroyuki Inoue, Hiroshi Itoh, Aika Hagiwara, Masaaki Sato, Kenichiro Kinouchi, Takuma Oshida, Kentaro Fujii, Kazutoshi Miyashita, Sho Endo
Publikováno v:
Journal of Hypertension
Background The renal tissue renin--angiotensin system is known to be activated by salt loading in salt-sensitive rats; however, the response in other organs remains unclear. Method Spontaneously hypertensive rats were subjected to normal tap water or
Autor:
Daniela Atanasovski, Jakob Näslund, Sven Melker Hagsäter, Elias Eriksson, Christopher Pettersson, Robert Pettersson
Publikováno v:
International Journal of Neuropsychopharmacology
Background Though drugs binding to serotonergic 5-HT2A receptors have long been claimed to influence human anxiety, it remains unclear if this receptor subtype is best described as anxiety promoting or anxiety dampening. Whereas conditioned fear expr
Publikováno v:
ACS Chemical Neuroscience. 12:2373-2384
Adenosine receptors (ARs) have been involved in neurodegenerative diseases such as Alzheimer disease, where oxidative stress contributes to neurodegeneration and cell death. Therefore, there is increasing interest in developing antioxidative strategi
Publikováno v:
Experimental Brain Research. 239:2435-2444
Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-like behaviors. In this study, (hypothyroidism group; HP group) adult male Sprague Dawley (SD) rats were induced to hypothyroidism after 5 weeks of exposure to
Publikováno v:
ESC Heart Failure, Vol 8, Iss 3, Pp 1979-1989 (2021)
ESC Heart Failure
ESC Heart Failure
Aims Prostaglandin E2 (PGE2) is involved in the development of cardiac hypertrophy. However, whether PGE2 regulates the chronic kidney disease‐associated cardiac hypertrophy and the tentative mechanism remains to be elucidated. Methods and results
Publikováno v:
Behavioral Neuroscience. 135:359-368
We previously reported that the dorsal raphe nucleus (DRN) was involved in the regulation of maternal care in lactating female mice. The DRN receives multiple innervations from a variety of the brain regions. Corticotropin-releasing factor (CRF) Type
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:609-618
Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthen