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Publikováno v:
J Med Chem
The endogenous neuropeptide FF (NPFF) and its two cognate G protein-coupled receptors, Neuropeptide FF Receptors 1 and 2 (NPFFR1 and NPFFR2), represent a relatively new target system for many therapeutic applications including pain regulation, modula
Autor:
José L. M. Madrigal, Juan C. Leza, Marta González-Prieto, Adriana Ortega-Hernández, Borja García-Bueno, Irene L Gutiérrez, Dulcenombre Gómez-Garre, Javier R. Caso
Publikováno v:
Glia. 69:73-90
The loss of noradrenergic neurons and subsequent reduction of brain noradrenaline (NA) levels are associated with the progression of Alzheimer's disease (AD). This seems to be due mainly to the ability of NA to reduce the activation of microglial cel
Autor:
Heike Vogel, Suzanne L. Dickson, Tina Bake, Christian E. Edvardsson, Marie V. Le May, Ulrika Bergström, Imre Farkas, Zsolt Liposits, Karolina P. Skibicka, Marjorie Nicholson Albers
Publikováno v:
Obesity. 28:1503-1511
OBJECTIVE The lateral parabrachial nucleus (lPBN) in the brainstem has emerged as a key area involved in feeding control that is targeted by several circulating anorexigenic hormones. Here, the objective was to determine whether the lPBN is also a re
Publikováno v:
The American Journal of Pathology. 190:1545-1564
To investigate the neuroprotective role of silent mating-type information regulation 2 homolog 1 (SIRT1) in Alzheimer disease (AD), brain tissues from patients with AD and APP/PS1 mice as well as primary rat neurons exposed to oligomers of amyloid-β
Autor:
Armando Teixeira-Pinto, Isaura Tavares, Ana Costa, Marília Sousa, Steven P. Wilson, Isabel Martins, Carlos Reguenga
Publikováno v:
Anesthesiology. 133:628-644
Background Increased descending pain facilitation accounts for opioid-induced hyperalgesia, but the underlying mechanisms remain elusive. Given the role of µ-opioid receptors in opioid-induced hyperalgesia in animals, the authors hypothesized that t
Autor:
Anna Blasiak, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Anna Gugula, Patryk Sambak, Ewa Błasiak, Grzegorz Hess, Agata Szlaga, Andrew L. Gundlach, Alan Kania, Mohammad Akhter Hossain
Publikováno v:
The Journal of Neuroscience
Binge-eating disorder is the most common eating disorder. Various neuropeptides play important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which stimulates food intake in rats through the activation of the relaxin-family
Autor:
Ahsas Goyal, Debapriya Garabadu
Publikováno v:
Behavioural Pharmacology. 31:671-687
Estrogen replacement therapy including specific estrogen receptor alpha (ERα) agonist, 4,4',4″-(4-propyl-[1H] pyrazole-1,3,5-triyl) trisphenol (PPT), improves cognitive function in the females with estrogen insufficiency condition. It is well sugg
Autor:
Jennifer L. Schmachtenberg, John F. Reed, Randy Torralva, Tracy L. Swanson, William E. Schutzer, Katherine M. Wolfrum, Amy J. Eshleman, Shelley H. Bloom, Aaron Janowsky
Publikováno v:
J Pharmacol Exp Ther
Synthetic opioids, including fentanyl and its analogs, have therapeutic efficacy in analgesia and anesthesia. However, their illicit use in the United States has increased and contributed to the number one cause of death for adults 18–50 years old.
Autor:
Muhammed Yayla, Ilknur Calik, Elif Cadirci, Abdulmecit Albayrak, Muhammet Calik, Busra Sirin, Irfan Cinar, Zekai Halici
Publikováno v:
Inflammopharmacology. 28:893-902
This study aimed to demonstrate the role of serotonin 7 receptor (5-HT7) and the effects of 5-HT7 agonists and antagonists in an indomethacin-induced gastric ulcer. Male albino Wistar rats (n = 60) were used in the experiments. LP44 (5-HT7 agonist) a
Autor:
Mi Sun Byun, Yuri Choi, In Bok An, Sang In Yang, Young Chul Sung, Hak Chul Jang, Jung Won Woo
Publikováno v:
Diabetes, Obesity & Metabolism
Aim To evaluate the pharmacokinetic and pharmacodynamic properties of a novel glycosylated Fc‐fused glucagon‐like peptide‐1(GLP‐1‐gFc) receptor agonist with distinctive receptor binding affinity, designed to improve in vivo stability and sa