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Autor:
Stephen N. Housley, Dario I. Carrasco, Paul Nardelli, Laura O'Farrell, Timothy C. Cope, Richard K. Noel, Travis M. Rotterman
Publikováno v:
Neurotoxicology
The persisting need for effective clinical treatment of chemotherapy-induced neurotoxicity (CIN) motivates critical evaluation of preclinical models of CIN for their translational relevance. The present study aimed to provide the first quantitative e
Autor:
Chinthalapally V. Rao, Yuting Zhang, Janani Panneerselvam, Vernon E. Steele, Venkateshwar Madka, Stanley Lightfoot, Gaurav Kumar, Gopal Pathuri, Altaf Mohammed, Chen S. Suen, Vishal Ganta, Ronald A. Lubet, Naveena B. Janakiram
Publikováno v:
Cancer Prevention Research. 14:1009-1020
Colorectal cancer causes over 53,000 deaths annually in the United States. Its rising incidences worldwide and particularly in young adults is a major concern. Here, we evaluated the efficacy of omeprazole that is clinically approved for treating aci
Publikováno v:
Environmental and Molecular Mutagenesis. 62:350-363
We have used whole genome sequencing (WGS) to determine mutational signatures induced in the T-cells of rats treated in vivo with N-propyl-N-nitrosourea (PNU) or procarbazine (PCZ). The signatures from the treated rats were different from the signatu
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND Alcohol excites neurons of the ventral tegmental area (VTA) and the release of dopamine from these neurons is a key event in ethanol (EtOH)-induced reward and reinforcement. Many mechanisms have been proposed to explain EtOH's actions on n
Autor:
Paul Vezina, Hanwen Zhang, Robert R. Butler, Alena Kozlova, Stephan Steidl, Jubao Duan, Zhiping P. Pang, Alan R. Sanders, Siwei Zhang, Thomas Ujas
Publikováno v:
Neuropsychopharmacology
Repeated nicotine exposure leads to sensitization (SST) and enhances self-administration (SA) in rodents. However, the molecular basis of nicotine SST and SA and their biological relevance to the mounting genome-wide association study (GWAS) loci of
Autor:
Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate, Munmun Pervin, Minto Nakagawa, Satoshi Matsuyama
Publikováno v:
The Journal of Veterinary Medical Science
Properties of macrophages and lymphocytes appearing in renal fibrosis remains to be investigated. F344 rats were injected once a week with cisplatin (2 mg/kg body weight) for 8 weeks and examined at post-final injection weeks 1, 3, 6, 9, and 12. Rats
Publikováno v:
Transplantation Proceedings. 52:992-1000
Background Macrophages may be important in chronic rejection after organ transplantation. This study aimed to investigate the possibility of depleting macrophages for a certain amount of time to alleviate chronic rejection in a heart transplant model
Autor:
Vernon E. Steele, Chinthalapally V. Rao, Altaf Mohammed, Yuting Zhang, Gopal Pathuri, Venkateshwar Madka, Adam S. Asch, Gaurav Kumar, Stanley Lightfoot
Publikováno v:
Cancer Prev Res (Phila)
Recent observational studies suggest that bisphosphonates (BP) and antidiabetic drugs are associated with colorectal cancer risk reduction. Hence, we evaluated the colorectal cancer preventive effects of BPs (zometa and fosamax), individually and whe
Autor:
Kodai Hino, Yoshihiro Maruo, Mitsuyoshi Nakao, Tomoko Kimura, Jun Udagawa, Noriko Nishikura, Yasuhiro Uchimura, Shinjiro Hino
Publikováno v:
The Journal of Nutrition. 150:212-221
BACKGROUND Epidemiological research indicates that iron deficiency (ID) in infancy correlates with long-term cognitive impairment and behavioral disturbances, despite therapy. However, the mechanisms underlying these effects are unknown. OBJECTIVE We
Autor:
Daewoo Han, Riccardo Serra, Charles G. Eberhart, Noah Gorelick, Betty Tyler, Umailla Fatima, Henry Brem, Andrew J. Steckl
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Interstitial chemotherapy plays a pivotal role in the treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain cancer, by enhancing drug biodistribution to the tumor and avoiding systemic toxicities. The use of new polymer stru