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Publikováno v:
Canadian Journal of Physiology and Pharmacology. 100:412-421
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including central obesity, hypertension, insulin resistance, dyslipidemia, and hyperglyemia. MetS is found to be a positive predictor of cardiovascular morbidity and mortality. The
Autor:
Hasan Caliskan, Metin Bastug, Deniz Billur, Goktug Omercioglu, Firat Akat, Şule Kizil, Belgin Can, Pinar Bayram, Hakan Fiçicilar
Publikováno v:
Experimental Physiology. 107:42-57
What is the central question of this study? We evaluated the effects of diabetes and exercise on lipopolysaccharide-induced acute lung injury. By providing a comprehensive analysis of redox status, blood gases and histological parameters, we aimed to
Autor:
Ruth M López Mayorga, Elvia Mera Jiménez, Betzabel Rodríguez-Reyes, Cecilia Tufiño, Rosa Amalia Bobadilla Lugo
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:1026-1035
Insulin resistance is a feature of pregnancy and is associated with increased levels of angiotensin II (Ang II) and insulin. Therefore, pregnancy may change insulin-induced vasodilation through changes in Ang II receptors. Insulin-induced vasorelaxat
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:1088-1096
Metabolic side effects of atypical antipsychotics are an important cause of deterioration of cognitive function and failure of drug adherence. The antifatty effect trypsin/chymotrypsin (T/C) and their mechanisms of action remain unclear. To investiga
Autor:
Philipp Gabriel, Aida Salameh, Beate Rassler, Christian Bölter, Peter Appelt, Nicole Fiedler, Katrin Schierle
Publikováno v:
Pflugers Archiv
Acute normobaric hypoxia may induce pulmonary injury with edema (PE) and inflammation. Hypoxia is accompanied by sympathetic activation. As both acute hypoxia and high plasma catecholamine levels may elicit PE, we had originally expected that adrener
Autor:
Ekram Nemr Abd Al Haleem, Sawsan Abo Bakr Zaytoon, Fatma Al –Zahraa Mohamed Ibrahim, Hossam M.M. Arafa
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:864-874
Peptic ulcers are one of the world's major gastrointestinal disorders, embracing both gastric and duodenal ulcers, and affecting 10% of the world population. The current study aimed to investigate the possible protective effect of tadalafil and pento
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:952-963
Isoniazid and rifampicin are crucial for treating tuberculosis (TB); however, they can cause severe hepatotoxicity leading to liver failure. Therapeutic options are limited and ineffective. We hypothesized that prophylaxis with quercetin attenuates i
Autor:
Xiaoli Luo, Pedro A. Jose, Caiyu Chen, Xue Gong, Cong Lan, Cheng Yu, Cuimei Hu, Chao Fan, Zaicheng Xu, Chunyu Zeng, Jialiang Wang, Hao Luo
Publikováno v:
Cardiovasc Res
Aims Exposure to maternal diabetes is associated with increased prevalence of hypertension in the offspring. The mechanisms underlying the prenatal programming of hypertension remain unclear. Because endoplasmic reticulum (ER) stress plays a key role
Autor:
Sandra Gabriela Vlachovsky, Claudia Silberstein, Nora Paula Goette, Elvira Arrizurieta, Fernando R. Ibarra, Luis A. Di Ciano, Pablo Javier Azurmendi, Elisabet M. Oddo
Publikováno v:
Experimental Physiology. 106:2107-2123
New findings What is the central question of this study? In a model of salt-sensitive hypertension in ovariectomized (oVx) adult Wistar rats, we evaluated the expression of proteins related to sodium transport in peripheral blood mononuclear cells (P
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 321:H259-H274
Underlying molecular mechanisms for the development of diabetic cardiomyopathy remain to be determined. Long-term exposure to hyperglycemia causes oxidative stress, which leads to cardiomyocyte dysfunction. Previous studies established the importance