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Autor:
Patrick M. Dougherty, Jacob Solis, Amina M. Illias, Hongmei Zhang, Juan P. Cata, Kai-Jie Yu, Seon-Hee Hwang, Jose F. Velasquez
Publikováno v:
Pain. 163:923-935
Activation of toll-like receptor 4 (TLR4) in the dorsal root ganglion (DRG) and spinal cord contributes to the generation of paclitaxel-related chemotherapy-induced peripheral neuropathy (CIPN). Generalizability of TLR4 signaling in oxaliplatin-induc
Autor:
Thoralf Opitz, Heinz Beck, Leonie Pothmann, Sarah Schmidt, Daniel Müller-Komorowska, Patrício Soares da Silva
Publikováno v:
Epilepsia. 62:542-556
Objective Many antiseizure drugs (ASDs) act on voltage-dependent sodium channels, and the molecular basis of these effects is well established. In contrast, how ASDs act on the level of neuronal networks is much less understood. Methods In the presen
Autor:
Anne Sofie Grell, Karin Warfvinge, Jacob C. A. Edvinsson, Kristian Agmund Haanes, Aida Maddahi, Lars Edvinsson, Diana N. Krause
Publikováno v:
Cephalalgia. 40:1283-1295
BackgroundRecent clinical findings suggest that oxytocin could be a novel treatment for migraine. However, little is known about the role of this neuropeptide/hormone and its receptor in the trigeminovascular pathway. Here we determine expression, lo
Autor:
Licheng Shi, Bryan D. Moyer, Margarida Martins-Oliveira, Hong Sun, Sonya G. Lehto, Peter J. Goadsby, Simon Akerman, Jan Hoffmann, Dawn Zhu, Weera Supronsinchai, Ruoyuan Yin, Cen Xu, Silke Miller, Judy Wang, Hantao Liu
Publikováno v:
Hoffmann, J R, Miller, S, Martins-Oliveira, M, Akerman, S, Supronsinchai, W, Sun, H, Shi, L, Wang, J, Zhu, D, Lehto, S, Liu, H, Yin, R, Moyer, B D, Xu, C & Goadsby, P 2020, ' PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache? ', Pain, vol. 161, no. 7, pp. 1670-1681 . https://doi.org/10.1097/j.pain.0000000000001858
Pain
Pain
PAC1 receptor blockade using a monoclonal antibody inhibits nociceptive neuronal activity in the trigeminocervical complex.
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclini
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclini
Autor:
Maurizio Popoli, Lucia Carboni, Laura Caberlotto, Aleksander A. Mathé, Luca Marchetti, Laura Musazzi, Mario Lauria, Enrico Domenici
Publikováno v:
European Neuropsychopharmacology. 31:69-85
Neurobiological underpinnings of treatment-resistant depression, a debilitating condition associated with significant functional impairment, have not been elucidated. Consequently, the aim of this study was to use animal models of response and resist
Publikováno v:
Neurological Research. 42:108-117
Objective: The possible effect of NMDAR (N-methyl-D-aspartate receptor)-NMNAT1/2 (nicotinamide/nicotinic acid mono-nucleotide adenylyltransferase) signaling pathway on the neuronal cell dam...
Publikováno v:
Neurourology and Urodynamics. 38:2112-2120
Aims The goal of this study was to test whether central corticotropin-releasing factor (CRF) was involved in angiotensin II (Ang II) and Ang II type 1 (AT1) receptor-mediated facilitation of micturition reflex and to investigate whether peripherally
Autor:
Guo-Fang Xue, Dongfang Li, Miao-Jing Tian, Ru-Lin Mi, Zhen-Yu Yuan, Rui-Fang Wang, Christian Hölscher
Publikováno v:
Epilepsy Research. 154:97-106
Aims Glia-mediated neuro-inflammation and oxidative stress-induced neuronal apoptosis can contribute to epileptogenesis. We have demonstrated previously that mimetics of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (G
Publikováno v:
The journal of pain, vol 22, iss 10
J Pain
J Pain
High molecular weight hyaluronan (HMWH), a prominent component of the extracellular matrix binds to and signals via multiple receptors, including cluster of differentiation 44 (CD44) and toll-like receptor 4 (TLR4). We tested the hypothesis that, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db008a5df89afa6bd716bc0dc063851
https://escholarship.org/uc/item/9g989116
https://escholarship.org/uc/item/9g989116
Autor:
Andrew J. Mannes, Michael J. Iadarola, Jenny Kim, Fernando A. Vazquez, Amelia J. Loydpierson, Dragan Maric, Mary K. Dougherty, Wallis T. Muhly, Radhika Narasimhan, Matthew R. Sapio, Taichi Goto
Publikováno v:
J Pain
During persistent pain, the dorsal spinal cord responds to painful inputs from the site of injury, but the molecular modulatory processes have not been comprehensively examined. Using transcriptomics and multiplex in situ hybridization, we identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59838bba9936948827ffc42b80722634
https://europepmc.org/articles/PMC9441406/
https://europepmc.org/articles/PMC9441406/