Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Victor H. Villar, Lynsey M. Meikle, Sheila Brown, Josephine Bunch, Emily K. Osterweil, Richard J. A. Goodwin, Maya Kamat, RuAngelie Edrada-Ebel, Justin J. J. van der Hooft, Michael J. Ormsby, Alex Dexter, Daniel Walker, Gillian Douce, Nicole Strittmatter, Julia M. Edgar, John G. Swales, Saverio Tardito, Jasper C. Komen, Ryan A. Bragg, Daniel M. Wall, Andrew S. MacDonald, Christopher J. Schofield, Heather Hulme, Stephanie A. Barnes, Richard Burchmore, Simon Milling
Publikováno v:
Hulme, H, Meikle, L M, Strittmatter, N, van der Hooft, J J J, Swales, J, Bragg, R A, Villar, V H, Ormsby, M J, Barnes, S, Brown, S L, Dexter, A, Kamat, M T, Komen, J C, Walker, D, Milling, S, Osterweil, E K, MacDonald, A S, Schofield, C J, Tardito, S, Bunch, J, Douce, G, Edgar, J M, Edrada-Ebel, R, Goodwin, R J A, Burchmore, R & Wall, D M 2020, ' Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication ', Science Advances, vol. 6, no. 11, eaax6328, pp. 1-10 . https://doi.org/10.1126/sciadv.aax6328
Science Advances 6 (2020) 11
Science Advances
Science Advances, 6(11)
Hulme, H, Meikle, L M, Strittmatter, N, van der Hooft, J J J, Swales, J, Bragg, R A, Villar, V H, Ormsby, M J, Barnes, S, Brown, S L, Dexter, A, Kamat, M T, Komen, J C, Walker, D, Milling, S, Osterweil, E K, MacDonald, A S, Schofield, C J, Tardito, S, Bunch, J, Douce, G, Edgar, J M, Edrada-Ebel, R, Goodwin, R J A, Burchmore, R & Wall, D M 2020, ' Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication ', Science Advances, vol. 6, no. 11, pp. eaax6328 . https://doi.org/10.1126/sciadv.aax6328
Science Advances 6 (2020) 11
Science Advances
Science Advances, 6(11)
Hulme, H, Meikle, L M, Strittmatter, N, van der Hooft, J J J, Swales, J, Bragg, R A, Villar, V H, Ormsby, M J, Barnes, S, Brown, S L, Dexter, A, Kamat, M T, Komen, J C, Walker, D, Milling, S, Osterweil, E K, MacDonald, A S, Schofield, C J, Tardito, S, Bunch, J, Douce, G, Edgar, J M, Edrada-Ebel, R, Goodwin, R J A, Burchmore, R & Wall, D M 2020, ' Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication ', Science Advances, vol. 6, no. 11, pp. eaax6328 . https://doi.org/10.1126/sciadv.aax6328
Discovery of novel bacterial metabolites reveals an unprecedented role for the microbiome in gut-brain axis communication.
Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identit
Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6425116aa951a24b358ad25d9af7f085
https://doi.org/10.1126/sciadv.aax6328
https://doi.org/10.1126/sciadv.aax6328
Autor:
Haitao Yang, Xiang Liu, Weihong Zhou, Han Wang, Luke W. Guddat, Christopher J. Schofield, Aili Zhang, Zihe Rao, Zuokun Lu, Cheng Yang
Because of β-lactamase–mediated resistance, β-lactam antibiotics were long considered ineffective drugs for tuberculosis (TB) treatment. However, some β-lactams, including meropenem and faropenem, are being re-evaluated in patients infected with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fedcaf708aeff7039577329a57679bf
https://doi.org/10.1124/mol.119.118042
https://doi.org/10.1124/mol.119.118042
Autor:
Jürgen Brem, Ricky Cain, Karina Calvopiña, Matthew B. Avison, Kate J. Heesom, Christopher J. Schofield, Samar Johnson, James Spencer, Philip Hinchliffe, Colin W. G. Fishwick, Christopher T. Lohans
Publikováno v:
Molecular Microbiology. 106:492-504
Clavulanic acid and avibactam are clinically deployed serine β-lactamase inhibitors, important as a defence against antibacterial resistance. Bicyclic boronates are recently discovered inhibitors of serine and some metallo β-lactamases. Here, we sh
Autor:
Lucas Tselepis, Dana E. Jackson, Jürgen Brem, Gareth W. Langley, Christopher J. Schofield, Timothy R. Walsh, Jonathan M. Tyrrell, Emma Widlake, Ali F. Aboklaish
Publikováno v:
International Journal of Antimicrobial Agents. 56:105925
Objectives: In vitro evaluation of the potential clinical efficacy of the novel β-lactam/β-lactamase-inhibitor combinations including imipenem-relebactam (IPM-REL) and cefepime-AAI101 (enmetazobactam) (FEP-AAI) against contemporary multidrug-resist
Publikováno v:
Antimicrobial agents and chemotherapy. 61(12)
Metallo-β-lactamases (MBLs) threaten the clinical utility of β-lactam antibiotics by hydrolyzing penicillins, cephalosporins, and carbapenems. Moreover, they can also hydrolyze all clinically used inhibitors (e.g., clavulanic acid, sulbactam, and t
Autor:
Valerie Castillo, Jürgen Brem, Maria F. Mojica, Alejandro J. Vila, Robert A. Bonomo, Leticia I. Llarrull, James Spencer, Magda Kosmopoulou, Ilaria Pettinati, Graciela Mahler, Philip Hinchliffe, Christopher J. Schofield, Mariano M. González
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Pathogenic Gram-negative bacteria resistant to almost all β-lactam antibiotics are a major public health threat. Zn(II)-dependent or metallo-β-lactamases (MBLs) produced by these bacteria inactivate most β-lactam antibiotics, including the carbape
Autor:
Deborah L. Mullen, Thalia I. Nicas, Jonathan W. Paschal, Loncharich Richard James, T. F. Butler, Nicholas J. Westwood, Eid Clark Norman, Cheng L, Christopher J. Schofield, Halligan Ng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0507e6eaa1262c7d845871b8957a34
https://ora.ox.ac.uk/objects/uuid:3e2a9b8f-f994-4cfd-a4c7-cd362dbaddf8
https://ora.ox.ac.uk/objects/uuid:3e2a9b8f-f994-4cfd-a4c7-cd362dbaddf8
Autor:
Jürgen Brem, Lynette M. Phee, David W. Wareham, Muhd Haziq F Abdul Momin, Jonathan W. Betts, Klaus-Daniel Umland, Christopher J. Schofield
Publikováno v:
MedChemComm. 7(1)
The thioenol ML302F was recently identified as an inhibitor of class B metallo-β-lactamases (MBLs). We assessed the activity of ML302F when combined with meropenem (MEM) against 31 carbapenem resistant Gram-negative clinical isolates. Minimum inhibi
Autor:
Siri Ram Chhabra, Mark C. Sleeman, Paul A. Smith, Barrie Kellam, Barrie W. Bycroft, Christopher J. Schofield
Publikováno v:
ChemBioChem. 5:879-882
A non-haem iron and 2-oxoglutarate oxygenase, CarC catalyses the highly unusual epimerisation and desaturation of a (3S,5S)-carbapenam 2 to give a (5R)-carbapenem 1. All stereoisomers of 2 were synthesised and analysed as CarC substrates. The results
Autor:
Candido Gude, Timothy A. Blizzard, Michael Shevlin, Rebecca T. Ruck, Helen Chen, Seongkon Kim, Nelo R. Rivera, Jane Y. Wu, Jason E. Imbriglio, Christopher J. Schofield, Ian Mangion, Jeffrey D. Hermes
Publikováno v:
Drug Intelligence & Clinical Pharmacy. 19:475-476
Numerous β-lactamase inhibitors have been developed to overcome the problems of bacterial resistance to β-lactam antibiotics. One such agent, clavulanic acid, has been combined with amoxicillin, and the combination is effective against many amoxici