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Autor:
Mohamed El-Shabrawy, Hisham Attia, Amal Mishriki, Mohamed Emam, Basma Emad Aboulhoda, Hanaa Wanas
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 48:811-819
The usefulness of cyclophosphamide (CP) in the treatment of multiple human malignancies and immunological diseases is hindered by the danger of developing nephrotoxicity. The toxic metabolites of CP are suggested to be responsible for oxidative stres
Autor:
Fatema Mohamed, Suhail Al-Salam, Priya Yuvaraju, Abderrahim Nemmar, Javed Yasin, Maitha A Kazim, Sumaya Beegam, Sara A Nuaman, Badreldin H. Ali
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss 1, Pp 1-16 (2021)
BACKGROUND/AIMS: Exposure to particulate air pollution is associated with increased cardiovascular morbidity and mortality. These effects are particularly aggravated in patients with pre-existing kidney diseases. Cerium oxide nanoparticles (CNPs), us
Autor:
Jan Slezak, Branislav Kura, Marko Fülöp, Katarina Andelova, Barbora Kalocayova, Ziad Abuawad, A. Sagatova, Barbara Szeiffova Bacova, Matus Sykora
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:80-88
Radiation damage of healthy tissues represents one of the complications of radiotherapy effectiveness. This study is focused on the screening of potentially effective drugs routinely used in medical practice and involved in the mechanism of radiation
Autor:
Reza Norouzirad, Asghar Ghasemi, Hamideh Afzali, Mohammad Khaksari, Khosrow Kashfi, Sajad Jeddi
Publikováno v:
Nitric Oxide. 103:20-28
Decreased nitric oxide bioavailability in skin contributes to impaired wound healing in type 2 diabetes (T2D). This study aims at determining effects of acidified nitrite on wound closure as well as inflammatory and antioxidants markers in wound tiss
Autor:
Saeed Esmaeili-Mahani, Ali Mohammad Pourrahimi, Mehdi Abbasnejad, Razieh Kooshki, Maryam Raoof
Publikováno v:
Pourrahimi, A M, Abbasnejad, M, Raoof, M, Esmaeili-Mahani, S & Kooshki, R 2021, ' The involvement of orexin 1 and cannabinoid 1 receptors within the ventrolateral periaqueductal gray matter in the modulation of migraine-induced anxiety and social behavior deficits of rats ', Peptides, vol. 146, 170651 . https://doi.org/10.1016/j.peptides.2021.170651
Peptides, 146:170651. Elsevier Inc.
Peptides, 146:170651. Elsevier Inc.
© 2021 Elsevier Inc.Orexin 1 receptors (Orx1R) and cannabinoid 1 receptors (CB1R) are implicated in migraine pathophysiology. This study evaluated the potential involvement of Orx1R and CB1R within the ventrolateral periaqueductal gray matter (vlPAG
Publikováno v:
Clinical and experimental pharmacologyphysiologyREFERENCES. 49(3)
Cardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury durin
Autor:
Keisuke Kamiya, Shuichi Hirai, Shoichi Maruyama, Hiroshi Kinashi, Hironobu Nobata, Akihiko Wakatsuki, Takuji Ishimoto, Kazushi Watanabe, Mai Yamauchi, Takayuki Katsuno, Jan Aten, Munekazu Naito, Yasuhiko Ito, Akimasa Asai, Naoyuki Hatayama, Makoto Yamaguchi
Publikováno v:
Physiological Reports
Physiological reports, 9(17):e15019. John Wiley and Sons Inc.
Asai, A, Hatayama, N, Kamiya, K, Yamauchi, M, Kinashi, H, Yamaguchi, M, Katsuno, T, Nobata, H, Watanabe, K, Wakatsuki, A, Aten, J, Maruyama, S, Ishimoto, T, Hirai, S, Naito, M & Ito, Y 2021, ' Roles of glomerular endothelial hyaluronan in the development of proteinuria ', Physiological Reports, vol. 9, no. 17, e15019 . https://doi.org/10.14814/phy2.15019
Physiological Reports, 9(17):e15019. John Wiley and Sons Inc.
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Physiological reports, 9(17):e15019. John Wiley and Sons Inc.
Asai, A, Hatayama, N, Kamiya, K, Yamauchi, M, Kinashi, H, Yamaguchi, M, Katsuno, T, Nobata, H, Watanabe, K, Wakatsuki, A, Aten, J, Maruyama, S, Ishimoto, T, Hirai, S, Naito, M & Ito, Y 2021, ' Roles of glomerular endothelial hyaluronan in the development of proteinuria ', Physiological Reports, vol. 9, no. 17, e15019 . https://doi.org/10.14814/phy2.15019
Physiological Reports, 9(17):e15019. John Wiley and Sons Inc.
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Vascular endothelial cells are covered with glycocalyx comprising heparan sulfate, hyaluronan, chondroitin sulfate, and associated proteins. Glomerular endothelial glycocalyx is involved in protecting against induction of proteinuria and structural d
Autor:
Rehab M Samaka, Samar M. Shahen, Moustafa R K Ali, Roba M. Talaat, Germine M. Hamdy, Mohamed R. Mohamed
Publikováno v:
Clinical and experimental pharmacologyphysiologyReferences. 48(10)
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes functional disability due to bone destruction and severe joint pain. Current anti-rheumatic treatments develop severe complications and do not provide complete remissi
Autor:
Manyu Song, Honggang Fan, Tianyuan Yang, Yuan Zhao, Wei Guan, Xiujing Feng, Yujie Yao, Chaoran Wang
Publikováno v:
Journal of Cellular Physiology. 234:18994-19009
Acute kidney injury (AKI) is a frequent and serious complication of sepsis; however, there are currently no effective therapies. Inflammation and oxidative stress are the major mechanisms implicated in lipopolysaccharide (LPS)-induced AKI. Dexmedetom
Autor:
Xue-Min Song, Chaoliang Tang, Peipei Guo, Zongze Zhang, Cheng-yao Wang, Jin Wang, Yanlin Wang, Xinyi Li, Zhao Jin, Huisheng Wu
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:886-892
This study aimed to investigate the protective effects of ketamine against hepatic ischemia–reperfusion (I/R) injury by suppressing activation of Kupffer cells (KCs) in rat liver autotransplantation. Male Sprague-Dawley rats were randomized into 3