Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thakur Gurjeet Singh"'
Autor:
Thakur Gurjeet Singh, Amarjot Kaur, Varinder Singh, Manjinder Singh, Ashi Mannan, Nikhil Garg
Publikováno v:
Current Drug Targets. 23:286-310
Monoamine oxidase (MAO) is an enzyme that catalyzes the deamination of monoamines and other proteins. MAO’s hyperactivation results in the massive generation of reactive oxygen species, which leads to a variety of neurological diseases such as Alzh
Autor:
Shareen Singh, Thakur Gurjeet Singh
Publikováno v:
Inflammation Research. 70:1027-1042
Mitochondrial dysfunction is a common denominator of neuroinflammation recognized by neuronal oxidative stress-mediated apoptosis that is well recognized by common intracellular molecular pathway-interlinked neuroinflammation and mitochondrial oxidat
Publikováno v:
Neurochemical Research. 46:2800-2831
Cerebral ischemic injury is a leading cause of death and long-term disability throughout the world. Peroxisome proliferator-activated receptor gamma (PPAR-ɣ) is a ligand-activated nuclear transcription factor that is a member of the PPAR family. PPA
Publikováno v:
Journal of Molecular Neuroscience. 71:1725-1742
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary injury mechanisms. Primary injury causes local brain damage, while secondary damage begins with inflammatory activity followed by disruption of the blood-brain bar
Publikováno v:
Current Drug Targets. 21:433-444
Alzheimer’s disease (AD) is a chronic intensifying incurable progressive disease leading to neurological deterioration manifested as impairment of memory and executive brain functioning affecting the physical ability like intellectual brilliance, c
Autor:
S.K. Gupta, Thakur Gurjeet Singh, Ajay Singh Kushwah, Gurteg Singh, Manish Kumar, Gurunath Surampalli
Publikováno v:
Biochemical and biophysical research communications. 577
Focal ischemia causes irreversible brain damage if cerebral blood flow is not restored promptly. Acute phase excitotoxicity and pro-oxidant and inflammatory events in the sub-chronic phase elicit coagulative necrosis, vascular injury, cerebral oedema
Publikováno v:
Mitochondrion. 59
Alzheimer’s disease (AD) is the inoperable, incapacitating, neuropsychiatric, and degenerative manifestation that drastically affects human life quality. The current medications target extra-neuronal senile plaques, oxidative stress, neuroinflammat
Autor:
Thakur Gurjeet Singh, Shareen Singh, Vivek Kumar Sharma, Manjinder Singh, Ashish K. Rehni, Rupinder Kaur
Publikováno v:
Mitochondrion. 58
Epileptogenesis is most commonly associated with neurodegeneration and a bioenergetic defect attributing to the fact that mitochondrial dysfunction plays a key precursor for neuronal death. Mitochondria are the essential organelle of neuronal cells n
Autor:
Anjali Singh, Thakur Gurjeet Singh, Heena Khan, Nikhil Garg, Komal Thapa, Amarjot Kaur Grewal
Publikováno v:
Brain research.
The cerebral ischemic reperfusion injury may leads to morbidity and mortality in patients. phosphatidylinositol 3-kinase (PI3K) signaling pathway has been believed to work in association with its downstream targets, other receptors, and pathways that
Publikováno v:
CNSneurological disorders drug targets. 19(10)
Epilepsy is the second most common neurological disease with abnormal neural activity involving the activation of various intracellular signalling transduction mechanisms. The molecular and system biology mechanisms responsible for epileptogenesis ar