Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Shaw, M"'
Publikováno v:
Aging (Albany NY)
Pancreatic ductal adenocarcinoma (PDAC) is a disease of aging. The TP53 gene product regulates cell growth, aging, and cancer. To determine the important targets of TP53 in PDAC, we examined the expression of 440 proteins on a reverse phase protein a
Autor:
Wang T., Hoekzema K., Vecchio D., Wu H., Sulovari A., Coe B. P., Gillentine M. A., Wilfert A. B., Perez-Jurado L. A., Kvarnung M., Sleyp Y., Earl R. K., Rosenfeld J. A., Geisheker M. R., Han L., Du B., Barnett C., Thompson E., Shaw M., Carroll R., Friend K., Catford R., Palmer E. E., Zou X., Ou J., Li H., Guo H., Gerdts J., Avola E., Calabrese G., Elia M., Greco D., Lindstrand A., Nordgren A., Anderlid B. -M., Vandeweyer G., Van Dijck A., Van der Aa N., McKenna B., Hancarova M., Bendova S., Havlovicova M., Malerba G., Bernardina B. D., Muglia P., van Haeringen A., Hoffer M. J. V., Franke B., Cappuccio G., Delatycki M., Lockhart P. J., Manning M. A., Liu P., Scheffer I. E., Brunetti Pierri N., Rommelse N., Amaral D. G., Santen G. W. E., Trabetti E., Sedlacek Z., Michaelson J. J., Pierce K., Courchesne E., Kooy R. F., Acampado J., Ace A. J., Amatya A., Astrovskaya I., Bashar A., Brooks E., Butler M. E., Cartner L. A., Chin W., Chung W. K., Daniels A. M., Feliciano P., Fleisch C., Ganesan S., Jensen W., Lash A. E., Marini R., Myers V. J., O'Connor E., Rigby C., Robertson B. E., Shah N., Shah S., Singer E., Snyder L. A. G., Stephens A. N., Tjernagel J., Vernoia B. M., Volfovsky N., White L. C., Hsieh A., Shen Y., Zhou X., Turner T. N., Bahl E., Thomas T. R., Brueggeman L., Koomar T., Michael R. J., O'Roak B. J., Barnard R. A., Gibbs R. A., Muzny D., Sabo A., Ahmed K. L. B., Eichler E. E., Siegel M., Abbeduto L., Hilscher B. A., Li D., Smith K., Thompson S., Albright C., Butter E. M., Eldred S., Hanna N., Jones M., Coury D. L., Scherr J., Pifher T., Roby E., Dennis B., Higgins L., Brown M., Alessandri M., Gutierrez A., Hale M. N., Herbert L. M., Schneider H. L., David G., Annett R. D., Sarver D. E., Arriaga I., Camba A., Gulsrud A. C., Haley M., McCracken J. T., Sandhu S., Tafolla M., Yang W. S., Carpenter L. A., Bradley C. C., Gwynette F., Manning P., Shaffer R., Thomas C., Bernier R. A., Fox E. A., Gerdts J. A., Pepper M., Ho T., Cho D., Piven J., Lechniak H., Soorya L. V., Gordon R., Wainer A., Yeh L., Ochoa-Lubinoff C., Russo N., Berry-Kravis E., Booker S., Erickson C. A., Prock L. M., Pawlowski K. G., Matthews E. T., Brewster S. J., Hojlo M. A., Abada E., Lamarche E., Murali S. C., Harvey W. T., Kaplan H. E., Pierce K. L., DeMarco L., Horner S., Pandey J., Plate S., Sahin M., Riley K. D., Carmody E., Constantini J., Esler A., Fatemi A., Hutter H., Landa R. J., McKenzie A. P., Neely J., Singh V., Van Metre B., Wodka E. L., Fombonne E. J., Huang-Storms L. Y., Pacheco L. D., Mastel S. A., Coppola L. A., Francis S., Jarrett A., Jacob S., Lillie N., Gunderson J., Istephanous D., Simon L., Wasserberg O., Rachubinski A. L., Rosenberg C. R., Kanne S. M., Shocklee A. D., Takahashi N., Bridwell S. L., Klimczac R. L., Mahurin M. A., Cotrell H. E., Grant C. A., Hunter S. G., Martin C. L., Taylor C. M., Walsh L. K., Dent K. A., Mason A., Sziklay A., Smith C. J., Nordenskjold M., Romano C., Peeters H., Gecz J., Xia K.
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature communications
Nature Communications, 11, 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, 11(1). NATURE RESEARCH
Nature Communications, 11
Nature communications
Nature Communications, 11, 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, 11(1). NATURE RESEARCH
Most genes associated with neurodevelopmental disorders (NDDs) were identified with an excess of de novo mutations (DNMs) but the significance in case–control mutation burden analysis is unestablished. Here, we sequence 63 genes in 16,294 NDD cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd59829750fcbc0b802de5b3fb7bdab7
https://escholarship.org/uc/item/9mh106j1
https://escholarship.org/uc/item/9mh106j1
Autor:
Lucio Cocco, Linda S. Steelman, Giuseppe Montalto, Shaw M. Akula, Stephen L. Abrams, James A. McCubrey, Saverio Candido, Alberto M. Martelli, Agnieszka Gizak, Stefano Ratti, Dariusz Rakus, Massimo Libra, Melchiorre Cervello
Publikováno v:
Advances in Biological Regulation
79 (2021). doi:10.1016/j.jbior.2020.100780
info:cnr-pdr/source/autori:Abrams SL; Akula SM; Martelli AM; Cocco L; Ratti S; Libra M; Candido S; Montalto G; Cervello M; Gizak A; Rakus D; Steelman LS; McCubrey JA;/titolo:Sensitivity of pancreatic cancer cells to chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals can be regulated by WT-TP53/doi:10.1016%2Fj.jbior.2020.100780/rivista:Advances in Biological Regulation (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:79
79 (2021). doi:10.1016/j.jbior.2020.100780
info:cnr-pdr/source/autori:Abrams SL; Akula SM; Martelli AM; Cocco L; Ratti S; Libra M; Candido S; Montalto G; Cervello M; Gizak A; Rakus D; Steelman LS; McCubrey JA;/titolo:Sensitivity of pancreatic cancer cells to chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals can be regulated by WT-TP53/doi:10.1016%2Fj.jbior.2020.100780/rivista:Advances in Biological Regulation (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:79
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic malignancy. Approximately 85% of pancreatic cancers are classified as PDACs. The survival of PDAC patients is very poor and only 5–10% of patients survive 5 years after diagnosis. Mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4dc94b168075da14e21c4cde71eb4b
http://hdl.handle.net/11585/855470
http://hdl.handle.net/11585/855470
Autor:
Lucio Cocco, Przemysław Duda, Peter P. Ruvolo, Massimo Libra, Giuseppe Montalto, Agnieszka Gizak, Stefano Ratti, Melchiorre Cervello, Shaw M. Akula, Linda S. Steelman, Dariusz Rakus, Stephen L. Abrams, Alberto M. Martelli, Akshaya K. Meher, Saverio Candido, James A. McCubrey, Luca Falzone
Publikováno v:
Cells 10 (2021). doi:10.3390/cells10040816
info:cnr-pdr/source/autori:Stephen L Abrams; Shaw M Akula; Akshaya K Meher; Linda S Steelman; Agnieszka Gizak; Przemys?aw Duda; Dariusz Rakus; Alberto M Martelli; Stefano Ratti; Lucio Cocco; Giuseppe Montalto; Melchiorre Cervello; Peter Ruvolo; Massimo Libra; Luca Falzone; Saverio Candido; James A McCubrey/titolo:GSK-3? Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals/doi:10.3390%2Fcells10040816/rivista:Cells/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Cells
Volume 10
Issue 4
Cells, Vol 10, Iss 816, p 816 (2021)
info:cnr-pdr/source/autori:Stephen L Abrams; Shaw M Akula; Akshaya K Meher; Linda S Steelman; Agnieszka Gizak; Przemys?aw Duda; Dariusz Rakus; Alberto M Martelli; Stefano Ratti; Lucio Cocco; Giuseppe Montalto; Melchiorre Cervello; Peter Ruvolo; Massimo Libra; Luca Falzone; Saverio Candido; James A McCubrey/titolo:GSK-3? Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals/doi:10.3390%2Fcells10040816/rivista:Cells/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Cells
Volume 10
Issue 4
Cells, Vol 10, Iss 816, p 816 (2021)
Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bc9ebd9624ff356255eb057b042a79
http://www.scopus.com/record/display.url?eid=2-s2.0-85105067732&origin=inward
http://www.scopus.com/record/display.url?eid=2-s2.0-85105067732&origin=inward
Autor:
Paolo Lombardi, Weifeng Mao, Linda S. Steelman, Alberto M. Martelli, Ramiro Mendonça Murata, Stefano Ratti, Saverio Candido, Dariusz Rakus, Melchiorre Cervello, Kvin Lertpiriyapong, Severino Matias de Alencar, Heng-Liang Lin, Shaw M. Akula, Stephen L. Abrams, Agnieska Gizak, Bruno Bueno-Silva, Massimo Libra, James A. McCubrey, Giuseppe Montalto, Matilde Y. Follo, Pedro Luiz Rosalen, Lucio Cocco
Publikováno v:
Advances in Biological Regulation
(2019): 22–40. doi:10.1016/j.jbior.2019.03.002
info:cnr-pdr/source/autori:Candido S; Abrams SL; Steelman LS; Lertpiriyapong K; Martelli AM; Cocco L; Ratti S; Follo MY; Murata RM; Rosalen PL; Bueno-Silva B; de Alencar SM; Lombardi P; Mao W; Montalto G; Cervello M; Rakus D; Gizak A; Lin H-L; Libra M; Akula SM; McCubrey JA;/titolo:Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and nutraceuticals/doi:10.1016%2Fj.jbior.2019.03.002/rivista:Advances in Biological Regulation (Print)/anno:2019/pagina_da:22/pagina_a:40/intervallo_pagine:22–40/volume
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
(2019): 22–40. doi:10.1016/j.jbior.2019.03.002
info:cnr-pdr/source/autori:Candido S; Abrams SL; Steelman LS; Lertpiriyapong K; Martelli AM; Cocco L; Ratti S; Follo MY; Murata RM; Rosalen PL; Bueno-Silva B; de Alencar SM; Lombardi P; Mao W; Montalto G; Cervello M; Rakus D; Gizak A; Lin H-L; Libra M; Akula SM; McCubrey JA;/titolo:Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and nutraceuticals/doi:10.1016%2Fj.jbior.2019.03.002/rivista:Advances in Biological Regulation (Print)/anno:2019/pagina_da:22/pagina_a:40/intervallo_pagine:22–40/volume
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Mutations at the TP53 gene are readily detected (approximately 50–75%) in pancreatic ductal adenocarcinoma (PDAC) patients. TP53 was previously thought to be a difficult target as it is often mutated, deleted or inactivated on both chromosomes in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b27b8241a23b78e27f036ba04f82278
http://www.scopus.com/record/display.url?eid=2-s2.0-85062951318&origin=inward
http://www.scopus.com/record/display.url?eid=2-s2.0-85062951318&origin=inward
Publikováno v:
Human Emerging and Re‐emerging Infections. :265-279
Publikováno v:
Archives of virology. 163(10)
Oncogenic viruses carry an extensive arsenal of oncogenes for hijacking cellular pathways. Notably, variations in oncogenes among tumor-producing viruses give rise to different mechanisms for cellular transformation. Specifically, Kaposi’s sarcoma-
Autor:
Gautret, P., Harvey, K., Pandey, P., Lim, P. L., Leder, K., Piyaphanee, W., Shaw, M., Mcdonald, S. C., Schwartz, E., Esposito, D. H., Parola, P., Delmont, J., Torresi, J., Brown, G., Yoshimura, Y., Tachikawa, N., Kurai, H., Sagara, H., Von Sonnenburg, F., Kanagawa, S., Kato, Y., Mizunno, Y., Hern, A., Chappuis, F., Loutan, L., Keystone, J. S., Kain, K., Grobusch, M., De Vries, P., Gadroen, K., Using, J., Froberg, G., Libman, M. D., Ward, B., Dick Maclean, J., Rapp, C., Aoun, O., Valdez, L. M., Siu, H., Cramer, J., Burchard, G. -D., Phu, P. T. H., Anderson, N., Batchelor, T., Meisch, D., Jensenius, M., Lalloo, D. G., Beeching, N. J., Stauffer, W., Walker, P., Kass, R., Jean Haulman, N., Roesel, D., Jong, E. C., Wang, A., Eason, J., Kendall, B., Hale, D. C., Anand, R., Gelman, S. S., Chen, L. H., Wilson, M. E., Silachamroon, U., Borwein, S., Van Genderen, P. J., Vincelette, J., Gurtman, A., Kozarsky, P. E., Wu, H., Fairley, J., Franco-Paredes, C., Schlagenhauf, P., Weber, R., Steffen, R., Yates, J., Ansdell, V., Mendelson, M., Vincent, P., Mockenhaupt, F., Harms, G., Perret, C., Valdivieso, F., Doyle, P., Ghesquiere, W., Cahill, J. D., Mckinley, G., Mccarthy, A., Caumes, E., Perignon, A., Anderson, S., Hynes, N. A., Bradley Sack, R., Mckenzie, R., Field, V., Connor, B. A., Muller, R., Freedman, D. O., Hagmann, S., Miller, A. O., Gkrania-Klotsas, E., Tenenboim, S., Jenks, N. P., Kerr, C., Licitra, C., Crespo, A., Castelli, F., Carosi, G., Holtom, P., Goad, J., Anglim, A.
Publikováno v:
Emerging Infectious Diseases, Vol 21, Iss 4, Pp 569-577 (2015)
Emerging Infectious Diseases
Emerging Infectious Diseases
No demographic characteristics identified who might benefit most from pretravel counseling.
Among travelers, rabies cases are rare, but animal bites are relatively common. To determine which travelers are at highest risk for rabies, we studied 2
Among travelers, rabies cases are rare, but animal bites are relatively common. To determine which travelers are at highest risk for rabies, we studied 2
Publikováno v:
Cell & Bioscience
Background Virus entry involves multiple steps and is a highly orchestrated process on which successful infection collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles via Western blotting, polymerase
Autor:
Shaw M. Akula, John F. Williams, Sergio Arce, Ossie F. Dyson, Hersh Patel, Wylder Fondaw, Lia R. Walker, Sheran Mahatme, Christopher M. Traylen
Publikováno v:
Future Virology. 6:451-463
Viruses are obligate intracellular parasites, relying to a major extent on the host cell for replication. An active replication of the viral genome results in a lytic infection characterized by the release of new progeny virus particles, often upon t