Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Serge Y. Fuchs"'
Publikováno v:
Nucleic Acids Research
Meiotic recombination enables reciprocal exchange of genetic information between parental chromosomes and is essential for fertility. MEIOB, a meiosis-specific ssDNA-binding protein, regulates early meiotic recombination. Here we report that the huma
Autor:
Curtis J. Pritzl, Bumsuk Hahm, Adrian B. McDermott, Madhuvanthi Vijayan, Chuan Xia, Serge Y. Fuchs
Publikováno v:
Journal of Virology. 90:2403-2417
Influenza A virus (IAV) employs diverse strategies to circumvent type I interferon (IFN) responses, particularly by inhibiting the synthesis of type I IFNs. However, it is poorly understood if and how IAV regulates the type I IFN receptor (IFNAR)-med
Autor:
Narayan G. Avadhani, Frank J. Gonzalez, Satish Srinivasan, Anil K. Rustgi, Serge Y. Fuchs, Haider Raza, Anindya Roy Chowdhury, Jyotirmoy Ghosh, Mrittika Chattopadhyay, Sabyasachi Bhattacharya, Moumita Bose
Publikováno v:
Toxicological Sciences.
We previously reported that mitochondrial CYP1 enzymes participate in the metabolism of polycyclic aromatic hydrocarbons and other carcinogens leading to mitochondrial dysfunction. In this study, using Cyp1b1(−)(/)(−), Cyp1a1/1a2(−)(/)(−), an
Autor:
Nathan Shores, Partha K. Chandra, Lili Bao, Tong Wu, Kyoung-Sub Song, Darren P. Baker, Curt H. Hagedorn, Srikanta Dash, Fatma M. Aboulnasr, William C. Wimley, Shuanghu Liu, Luis A. Balart, Serge Y. Fuchs
Publikováno v:
The American Journal of Pathology. 184(1):214-229
A stable and persistent Hepatitis C virus (HCV) replication cell culture model was developed to examine clearance of viral replication during long-term treatment using interferon-α (IFN-α), IFN-λ, and ribavirin (RBV). Persistently HCV-infected cel
Autor:
Yan Li, Albert C. Koong, Constantinos Koumenis, Haiyan Zhang, George J. Cerniglia, John T. Cunningham, Lori S. Hart, Alexander E. Perl, Davide Ruggero, Andrei Thomas-Tikhonenko, Bo Qiu, Amit Maity, J. Alan Diehl, Serge Y. Fuchs, Ian G. Mills, Yan Gao, Changhong Li, Souvik Dey, Feven Tameire, Stacey L. Lehman, Meixia Bi, Huayi Liu, Tatini Datta
Publikováno v:
The Journal of clinical investigation, vol 122, iss 12
The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the pathogenic state, c-Myc–induced apoptosis is bypassed via a critical, yet poorly understood escape mechanism that promotes cellular transformation and tumorig
Autor:
Andrei V. Ougolkov, Vladimir Bilim, Toshinari Minamoto, Kaname Yamashita, Masayoshi Mai, Bin Zhang, Serge Y. Fuchs
Publikováno v:
JNCI Journal of the National Cancer Institute. 96:1161-1170
BACKGROUND The ubiquitin-proteasome pathway is important in regulating protein signaling pathways that are involved in tumorigenesis. beta-transducin repeat-containing proteins (beta-TrCP) are components of the ubiquitin ligase complex targeting beta
Autor:
Boun L Thai, Serge Y. Fuchs, Yuval Shaked, Jane Lee, Yaacov Ben-David, Robert S. Kerbel, Brian J Pak, Ze'ev Ronai
Publikováno v:
Oncogene. 23:30-38
While melanomas are resistant to the cytotoxic effects of radiotherapy, little is known about the molecular mechanisms underlying this intrinsic resistance. Here, we describe the utilization of retroviral insertional mutagenesis to facilitate the ana
Autor:
Serge Y. Fuchs
Publikováno v:
Cancer Biology & Therapy. 1:336-340
Oncogenic activation of genes that regulate cell proliferation and survival plays a central role in the development of human cancer. This activation is frequently achieved by the aberrant expression of oncogene products due to the gene amplification,
Autor:
Serge Y. Fuchs, Victor Adler, Toshinari Minamoto, Thomas Buschmann, Ze'ev Ronai, Nikhil Wagle, Masyoshi Mai
Publikováno v:
Journal of Molecular Biology. 295:1009-1021
Identification of Mdm2 and JNK as proteins that target degradation of wt p53 prompted us to examine their effect on mutant p53, which exhibits a prolonged half-life. Of five mutant p53 forms studied for association with the targeting molecules, two n
Autor:
Serge Y. Fuchs
After several decades of intense clinical research, the great promise of Type I interferons (IFN1) as the anticancer wonder drugs that could cure or, at the very least, curb the progression of various oncological diseases has regrettably failed to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68381c6429645dc3569cc05f97551aa
https://europepmc.org/articles/PMC3624693/
https://europepmc.org/articles/PMC3624693/