Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Rossella Manfredini"'
Autor:
Matteo Lulli, Alessandro M. Vannucchi, Manjola Balliu, Niccolò Bartalucci, Rossella Manfredini, Laura Calabresi, Laura Maggi, Paola Guglielmelli, Simone Romagnoli
Publikováno v:
Blood Adv
Calreticulin (CALR), an endoplasmic reticulum–associated chaperone, is frequently mutated in myeloproliferative neoplasms (MPNs). Mutated CALR promotes downstream JAK2/STAT5 signaling through interaction with, and activation of, the thrombopoietin
Autor:
Chiara Rossi, Roberta Zini, Sebastiano Rontauroli, Samantha Ruberti, Zelia Prudente, Greta Barbieri, Elisa Bianchi, Simona Salati, Elena Genovese, Niccolò Bartalucci, Paola Guglielmelli, Enrico Tagliafico, Vittorio Rosti, Giovanni Barosi, Alessandro M. Vannucchi, Rossella Manfredini, the AGIMM (AIRC‐Gruppo Italiano Malattie Mieloproliferative) investigators
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 12, Iss 12, Pp 2102-2123 (2018)
Molecular Oncology, Vol 12, Iss 12, Pp 2102-2123 (2018)
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by an excessive production of pro-inflammatory cytokines resulting in chronic inflammation and genomic instability. Besides the driver mutations in JAK2, MPL, and CALR genes,
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Autor:
Anette-Gabriele Ziegler, Isabelle Serr, Adam M. Zahm, Saverio Bellusci, Katharina Gerlach, Martin G. Scherm, Victoria K. Salb, Rossella Manfredini, Benno Weigmann, Carolin Daniel, Jonathan Schug, Klaus H. Kaestner
Publikováno v:
Nat. Commun. 10:5697 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e536d3d68712489a059ba724008a1e14
https://hdl.handle.net/11380/1221487
https://hdl.handle.net/11380/1221487
Autor:
Rossella Manfredini, Simona Salati, Valentina Pennucci, Enrico Tagliafico, Paola Guglielmelli, Elisa Bianchi, Elena Enzo, Samantha Ruberti, Carmela Mannarelli, Alessandro M. Vannucchi, Niccolò Bartalucci, Elena Genovese, Chiara Carretta, Zelia Prudente, Chiara Rossi, Laura Calabresi, Sebastiano Rontauroli, Manjola Balliu, Roberta Zini
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Somatic mutations of calreticulin (CALR) have been described in approximately 60–80% of JAK2 and MPL unmutated Essential Thrombocythemia and Primary Myelofibrosis patients. CALR is an endoplasmic reticulum (ER) chaperone responsible for proper prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0feb88299b71898c389a3cd041c9973
https://hdl.handle.net/11380/1183743
https://hdl.handle.net/11380/1183743
Autor:
Emanuela Sant'Antonio, Francesco Passamonti, Lisa Pieri, Tiziano Barbui, Alessandro M. Vannucchi, Elisa Rumi, Rossella Manfredini, Annalisa Pacilli, Daniela Cilloni, Clara Belotti, Tiziana Fanelli, Mario Cazzola, Silvia Salmoiraghi, Federica Delaini, Paola Guglielmelli, Giada Rotunno, Daniela Pietra, Valentina Artusi, Margherita Maffioli, Enrico Tagliafico, Alessandro Pancrazzi, Isabella Bernardis, Alessandro Rambaldi, Giada Brogi
Publikováno v:
American Journal of Hematology. 91:681-686
Transformation to secondary myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PPV-MF) and essential thrombocythemia (PET-MF). Although primary (PMF) and secondary MF are considered similar diseases and managed similarly,
Autor:
Roberta Zini, Paola Guglielmelli, Daniela Pietra, Elisa Rumi, Chiara Rossi, Sebastiano Rontauroli, Elena Genovese, Tiziana Fanelli, Laura Calabresi, Elisa Bianchi, Simona Salati, Mario Cazzola, Enrico Tagliafico, Alessandro M. Vannucchi, Rossella Manfredini, on behalf of the AGIMM (AIRC Gruppo Italiano Malattie Mieloproliferative) investigators
Publikováno v:
Blood Cancer Journal, Vol 7, Iss 12, Pp 1-13 (2017)
Blood Cancer Journal
Blood Cancer Journal
Polycythemia vera (PV) and essential thrombocythemia (ET) are Philadelphia-negative myeloproliferative neoplasms (MPNs) characterized by erythrocytosis and thrombocytosis, respectively. Approximately 95% of PV and 50–70% of ET patients harbor the V
Autor:
Carmela Mannarelli, Elisa Bianchi, Paola Guglielmelli, Niccolò Bartalucci, Sebastiano Rontauroli, Samantha Ruberti, Chiara Rossi, Chiara Carretta, Rossella Manfredini, Elena Genovese, Zelia Prudente, Simona Salati, Valentina Pennucci, Alessandro M. Vannucchi, Roberta Zini, Enrico Tagliafico
Publikováno v:
Blood. 132:4332-4332
Somatic mutations of calreticulin (CALR) have been described in approximately 30-40% of JAK2 and MPL unmutated Essential Thrombocythemia and Primary Myelofibrosis patients. CALR is an endoplasmic reticulum (ER) chaperone responsible for proper protei
Autor:
Rossella Manfredini, Laura Calabresi, Niccolò Bartalucci, Laura Maggi, Manjola Balliu, Francesco Annunziato, Simona Salati, Paola Guglielmelli, Alessandro M. Vannucchi
Publikováno v:
Blood. 132:1780-1780
INTRODUCTION. Calreticulin (CALR) is mutated in 20% of pts with essential thrombocythemia (ET) and primary myelofibrosis (PMF). The most frequent mutations are a 52 bp deletion (T1) and a 5 bp insertion (T2) in exon 9, that cause a recurrent frameshi
Autor:
Ayalew Tefferi, C A Hanson, Rossella Manfredini, Naseema Gangat, Elisa Rumi, Paola Guglielmelli, Carmela Mannarelli, Daniela Pietra, Rhett P. Ketterling, Alberto Bosi, Flavia Biamonte, Andreas Reiter, Nicholas C.P. Cross, Marie Cazzola, Andrew S Duncombe, Animesh Pardanani, Francisco Cervantes, Joannah Score, Alessandro M. Vannucchi, Ryan A. Knudson, Christy Finke, Tiziana Fanelli, Arturo Pereira, Alessandro Pancrazzi, Giovanni Barosi, Katerina Zoi, Giada Rotunno, Terra L. Lasho
Publikováno v:
Leukemia. 28(9)
We recently defined a high-molecular risk category (HMR) in primary myelofibrosis (PMF), based on the presence of at least one of the five 'prognostically detrimental' mutated genes (ASXL1, EZH2, SRSF2 and IDH1/2). Herein, we evaluate the additional
Autor:
Valentina Carrai, Alessandro M. Vannucchi, Lisa Pieri, Giulia Raugei, Niccolò Bartalucci, Paola Guglielmelli, Giada Rotunno, Alberto Bosi, Rajmonda Fjerza, Rossella Manfredini, Carmela Mannarelli, Laura Calabresi, Manjola Balliu, Annalisa Pacilli
Publikováno v:
Leukemia
Mutations in the gene calreticulin (CALR) occur in the majority of JAK2- and MPL-unmutated patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF); identifying CALR mutations contributes to the diagnostic pathway of ET and PMF. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c43e9224db9e2b105dfda4fec36b93
https://hdl.handle.net/11380/1074844
https://hdl.handle.net/11380/1074844