Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Oleg Iartchouk"'
Autor:
Zachary Zwirko, Mina Mostafavi, Thomas W. Willis, Adriana K. Jones, Patrick Lee, Oleg Iartchouk, Srijan Ranjitkar, John R. Walker, S. Whitney Barnes, Charles R. Dean
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. D13-9001 specifically inhibits MexAB-OprM in Pseudomonas aeruginosa Mutants with decreased suscep
Autor:
Natalia Kurepina, Sam Bozeman, Maha R. Farhat, Alexander Sloutsky, James E. Galagan, Elizabeth M. Streicher, Tommie C. Victor, Razvan Sultana, Megan Murray, Karen R. Jacobson, Barry N. Kreiswirth, Hanna Nebenzahl-Guimaraes, Robin M. Warren, Christian Stolte, Dick van Soolingen, Leen Rigouts, James E. Posey, Peter Sisk, Devinder Kaur, Oleg Iartchouk
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 194, 5, pp. 621-30
Europe PubMed Central
American Journal of Respiratory and Critical Care Medicine, 194, 621-30
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
American journal of respiratory and critical care medicine
Europe PubMed Central
American Journal of Respiratory and Critical Care Medicine, 194, 621-30
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
American journal of respiratory and critical care medicine
Item does not contain fulltext RATIONALE: The development of molecular diagnostics that detect both the presence of Mycobacterium tuberculosis in clinical samples and drug resistance-conferring mutations promises to revolutionize patient care and int
Autor:
Christopher B. Ford, Nilofar Mohaideen, Marc Lipsitch, Rupal R. Shah, Philana Ling Lin, JoAnne L. Flynn, Sarah M. Fortune, James E. Galagan, Oleg Iartchouk, James C. Sacchettini, Thomas R. Ioerger, Michael R. Chase
Publikováno v:
Nature genetics
Mycobacterium tuberculosis (Mtb) has generated a global health catastrophe that has been compounded by the emergence of drug resistant Mtb strains. We used whole genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomolg
Autor:
Yosuf Yassin, A. Thomas Look, Michael A. Caligiuri, Jordan M. Winter, Oleg Iartchouk, Mignon L. Loh, Ralph H. Hruban, Susan P. Whitman, Mohamed Bentires-Alj, Rupinder Grewal, Scott E. Kern, Kenneth D. Swanson, D. Gary Gilliland, Benjamin G. Neel, Kate Montgomery, Marcelo Reis, Charles J. Yeo, Matthew Meyerson, Raju Kucherlapati, Heidi Greulich
Publikováno v:
Genes, Chromosomes and Cancer. 47:253-259
Germ line gain-of-function mutations in several members of the RAS/ERK pathway, including PTPN11, KRAS, and RAF1, cause the autosomal dominant genetic disorder Noonan Syndrome (NS). NS patients are at increased risk of leukemia/myeloproliferative dis
Autor:
Chloe E. Atreya, Alan P. Venook, James M. Watters, Madelyn Light, Robert S. Warren, Joon Sang Lee, Steve Rowley, Oleg Iartchouk
Publikováno v:
Journal of Clinical Oncology. 32:470-470
470 Background: A comprehensive molecular characterization of primary colorectal cancers (CRC) was recently reported. Less is known about mutation patterns in CRC metastases and association with survival. Our sequencing analysis focused on CRC liver
Autor:
Joachim Theihaber, Zhihu Ding, Yu-an Zhang, Serena J. Silver, James Watters, Oleg Iartchouk, Joshua Murtie, Zhifang Li, Hongyun Wang, Gary Shapiro, Hui Cao, Stephan Reiling, Jack Pollard, Saurin Jani, Christoph Lengauer, Dietmar Hoffman, Angela Virone-Oddos, Venkat Reddy, Bin Wu, Jingxin Zhang, Richard Newcombe, Madelyn Light, May Cindhuchao, Eva Bric-Furlong
Publikováno v:
Cancer Research. 73:3135-3135
Functional genomic screens have been employed by many groups to identify novel targets for cancer therapeutics. However, translation of these data sets into new drug discovery programs has proved challenging, in part due to difficulties in obtaining