Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Manabu, Igarashi"'
Publikováno v:
PeerJ Physical Chemistry, Vol 3, p e19 (2021)
The substitution of Ile to Val at residue 117 (I117V) of neuraminidase (NA) reduces the susceptibility of the A/H5N1 influenza virus to oseltamivir (OTV). However, the molecular mechanism by which the I117V mutation affects the intermolecular interac
Autor:
Shiho Torii, Tsogtbaatar Urangoo, Keita Matsuno, Yoshihiro Takadate, Khanui Buyantogtokh, Takeshi Saito, Kosuke Okuya, Ankhanbaatar Ulaankhuu, Khishgee Bodisaikhan, Takanari Hattori, Masatoshi Okamatsu, Manabu Igarashi, Yoshihiro Sakoda, Jargalsaikhan Tserenjav, Damdinjav Batchuluun, Yurie Kida, Hiroshi Kida, Mao Isono, Junki Maruyama, Tsolmon Amartuvshin, Masahiro Sato, Enkhbold Bazarragchaa, Takahiro Hiono, Ayato Takada, Tatsunari Kondoh, Nodoka Kasajima
Publikováno v:
Virus Genes
The circulation of highly pathogenic avian influenza viruses (HPAIVs) of various subtypes (e.g., H5N1, H5N6, H5N8, and H7N9) in poultry remains a global concern for animal and public health. Migratory waterfowls play important roles in the transmissi
Autor:
Masahiro Nakano, Yoko Fujita-Fujiharu, Yugo Tsunoda, Yukiko Muramoto, Kazuya Houri, Yukihiko Sugita, Yuki Takamatsu, Stephan Becker, Takeshi Noda, Manabu Igarashi
The nucleoprotein (NP) of Marburg virus (MARV), a close relative of Ebola virus (EBOV), encapsidates the single-stranded, negative-sense viral genomic RNA (vRNA) to form the helical NP-RNA complex. The NP-RNA complex serves as a scaffold for the asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::606a8beffef02b46d6ef634bd944bf17
https://doi.org/10.1101/2021.07.13.452116
https://doi.org/10.1101/2021.07.13.452116
Publikováno v:
PeerJ
PeerJ, Vol 9, p e11552 (2021)
PeerJ, Vol 9, p e11552 (2021)
Background Oseltamivir (OTV)-resistant influenza virus exhibits His-to-Tyr mutation at residue 274 (H274Y) in N1 neuraminidase (NA). However, the molecular mechanisms by which the H274Y mutation in NA reduces its binding affinity to OTV have not been
Autor:
Katherine M Fuller, Erica Ollmann Saphire, Manabu Igarashi, Ayato Takada, Diptiben V. Parekh, Jacob C. Milligan
Publikováno v:
The Journal of Infectious Diseases. 219:415-419
Ebola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, although they are ineffective against other members of the Ebolavirus g
Autor:
Takeshi Saito, Yoshihiro Takadate, Rashid Manzoor, Hiroko Miyamoto, Manabu Igarashi, Ayato Takada, Yurie Kida, Hirohito Ogawa, Junki Maruyama, Masahiro Kajihara, Tatsunari Kondoh
Publikováno v:
Microorganisms, Vol 8, Iss 1530, p 1530 (2020)
Microorganisms
Volume 8
Issue 10
Microorganisms
Volume 8
Issue 10
Lloviu virus (LLOV), a bat-derived filovirus that is phylogenetically distinct from human pathogenic filoviruses such as Ebola virus (EBOV) and Marburg virus (MARV), was discovered in Europe. However, since infectious LLOV has never been isolated, th
Publikováno v:
Viruses
Volume 13
Issue 5
Viruses, Vol 13, Iss 913, p 913 (2021)
Volume 13
Issue 5
Viruses, Vol 13, Iss 913, p 913 (2021)
Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to th
Autor:
Xinhao Li, Kazuki Takeda, Dhoha Triki, Manabu Igarashi, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Denis Fourches, Shouta M.M. Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka
Publikováno v:
Pesticide biochemistry and physiology. 173:104774
Well-known 4-hydroxycoumarin derivatives, such as warfarin, act as inhibitors of the vitamin K epoxide reductase (VKOR) and are used as anticoagulants. Mutations of the VKOR enzyme can lead to resistance to those compounds. This has been a problem in
Autor:
Kosuke Okuya, Reiko Yoshida, Tatsunari Kondoh, Sakaitani Masahiro, Asuka Nanbo, Manabu Igarashi, Masahiro Kajihara, Mao Isono, Wakako Furuyama, Makoto Kuroda, Andrea Marzi, Heinz Feldmann, Ayato Takada, Hiroko Miyamoto, Rashid Manzoor
Publikováno v:
Antiviral Research. 183:104932
Ebolaviruses and marburgviruses, members of the family Filoviridae, are known to cause fatal diseases often associated with hemorrhagic fever. Recent outbreaks of Ebola virus disease in West African countries and the Democratic Republic of the Congo
Autor:
Hirofumi Sawa, Bernard M. Hang’ombe, Kimihito Ito, Hiroko Miyamoto, Katendi Changula, Chihiro Sugimoto, Makoto Kuroda, Keita Matsuno, Ichiro Nakamura, Manabu Igarashi, Junki Maruyama, Jackson Katampi, Yuka Thomas, Ayato Takada, Akihiro Ishii, Naganori Nao, Emiko Nakagawa, Heinz Feldmann, Aaron S. Mweene, Andrew Nambota, Mieko Muramatsu, Reiko Yoshida, Eri Nakayama, Masahiro Kajihara, Edgar Simulundu, Hirohito Ogawa, Ladslav Moonga, Boniface Namangala
Publikováno v:
Journal of Infectious Diseases. 212(2):S101-S108
Fruit bats are suspected to be a natural reservoir of filoviruses, including Ebola and Marburg viruses. Using an enzyme-linked immunosorbent assay based on the viral glycoprotein antigens, we detected filovirus-specific immunoglobulin G antibodies in