Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lucia Knopfová"'
Autor:
Petr Beneš, Roman Huley, Monika Dúcka, Taras Gutor, Orest Petronchak, Lucia Knopfová, Lubor Borsig, Nataliya Volodko, Jan Šmarda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Tumor-associated macrophages (TAMs) are prominent components of tumor stroma that promotes tumorigenesis. Many soluble factors participate in the deleterious cross-talk between TAMs and transformed cells; however mechanisms how tumors orchestrate the
Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma
Autor:
Lenka Veverková, Jiří Jarkovský, Ivan Čapov, Petr Beneš, Jana Katolická, Jan Šmarda, Markéta Hermanová, Lucie Pekarčíková, Petr Vlček, Tichý M, Lucia Knopfová
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis.
Autor:
Sára Lenárt, Šárka Šimečková, Radek Fedr, Zuzana Kahounová, Jan Bouchal, Petr Beneš, Gvantsa Kharaishvili, Lucia Binó, Eva Slabáková, Milan Král, Tereza Kučírková, Ján Remšík, Lucia Knopfová, Karel Souček, Ximena Maria Muresan
Publikováno v:
Carcinogenesis. 39(11)
The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype i
Autor:
Vojtech Adam, Petr Babula, Monika Holubová, Martina Raudenská, Markéta Sztalmachová, Michal Masarik, Jaromír Gumulec, Jan Balvan, Hana Polanska, René Kizek, Lucia Knopfová, Kristyna Hudcova
Publikováno v:
International Journal of Oncology. 46:1810-1818
Breast cancer patients negative for the nuclear oestrogen receptor α have a particularly poor prognosis. Therefore, the 4T1 cell line (considered as a triple-negative model) was chosen to induce malignancy in mice. The aim of the present study was t
Autor:
Lucia Knopfová, Eva Slabáková, Jan Bouchal, Ján Remšík, Gvantsa Kharaishvili, Petr Beneš, Lucia Binó, Tereza Nehybová, Radek Fedr, Šárka Šimečková, Karel Souček, Milan Král, Zuzana Kahounová
Publikováno v:
Cancer Research. 78:B084-B084
Dissemination of cancer cells to distant organs has fatal consequences to most of the patients with malignant tumors. Patients with prostate and breast cancer show apparent overlap of the most common sites of cancer metastasis, suggesting that breast
Publikováno v:
Environmental and Molecular Mutagenesis. 53:515-524
Wedelolactone is one of the active plant polyphenolic compounds. Anti-tumor effects of this drug have been demonstrated recently. We have described that wedelolactone acts as catalytic inhibitor of DNA topoisomerase IIα. The aim of this study was to
Publikováno v:
Pathology. 46:S76
Transcription factor c-Myb is required for maintenance of progenitor cells in colon epithelium. Deregulation of c-Myb is frequently linked with tumorigenesis. For colorectal carcinomas, high c-Myb expression denotes tumors with poor prognosis. Oxidat