Zobrazeno 1 - 10
of 63
pro vyhledávání: '"John McLauchlan"'
Autor:
Connor G. G. Bamford, Cuncai Guo, Jonathon D. Coey, John McLauchlan, Benjamin Lang, Steeve Boulant, Dorothee Reuss, Swathi Sukumar, Megan L. Stanifer
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Guo, C, Reuss, D, Coey, J D, Sukumar, S, Lang, B, McLauchlan, J, Boulant, S, Stanifer, M L & Bamford, C G G 2021, ' Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins ', Frontiers in immunology, vol. 12, 772588 . https://doi.org/10.3389/fimmu.2021.772588
Frontiers in Immunology, Vol 12 (2021)
Guo, C, Reuss, D, Coey, J D, Sukumar, S, Lang, B, McLauchlan, J, Boulant, S, Stanifer, M L & Bamford, C G G 2021, ' Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins ', Frontiers in immunology, vol. 12, 772588 . https://doi.org/10.3389/fimmu.2021.772588
Interferon lambdas (IFN{lambda}) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver and gastrointestinal tract. Humans have four IFN{lambda}s (1-4) where IFN{lambda}1-3
Autor:
Ana da Silva Filipe, David F. Bibby, Elihu Aranday-Cortes, Emma Hudson, Jennifer Benselin, Phil Troke, Carmen F. Manso, Brendan Healy, Daniel Bradshaw, Anthony Brown, David A. Smith, Joshua B Singer, John McLauchlan, William L. Irving, Eleanor Barnes, Jean L. Mbisa, M. Azim Ansari, E. Thomson
Sustained viral response (SVR) rates for direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection routinely exceed 95%. However, a small number of patients require retreatment. Sofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2552a93f122a0fcf33b2e6e4a440b82b
Autor:
Clark D Russell, Cameron J Fairfield, Thomas M Drake, Lance Turtle, R Andrew Seaton, Dan G Wootton, Louise Sigfrid, Ewen M Harrison, Annemarie B Docherty, Thushan I de Silva, Conor Egan, Riinu Pius, Hayley E Hardwick, Laura Merson, Michelle Girvan, Jake Dunning, Jonathan S Nguyen-Van-Tam, Peter J M Openshaw, J Kenneth Baillie, Malcolm G Semple, Antonia Ho, Peter JM Openshaw, Gail Carson, Beatrice Alex, Benjamin Bach, Wendy S Barclay, Debby Bogaert, Meera Chand, Graham S Cooke, Ana da Silva Filipe, Tom Fletcher, Christopher A Green, Julian A Hiscox, Antonia YW Ho, Peter W Horby, Samreen Ijaz, Say Khoo, Paul Klenerman, Andrew Law, Wei Shen Lim, Alexander J Mentzer, Alison M Meynert, Mahdad Noursadeghi, Shona C Moore, Massimo Palmarini, William A Paxton, Georgios Pollakis, Nicholas Price, Andrew Rambaut, David L Robertson, Vanessa Sancho-Shimizu, Janet T Scott, Thushan de Silva, Tom Solomon, Shiranee Sriskandan, David Stuart, Charlotte Summers, Richard S Tedder, Emma C Thomson, AA Roger Thompson, Ryan S Thwaites, Lance CW Turtle, Rishi K Gupta, Carlo Palmieri, Maria Zambon, Hayley Hardwick, Chloe Donohue, Ruth Lyons, Fiona Griffiths, Wilna Oosthuyzen, Lisa Norman, Stephen R Knight, Kenneth A Mclean, Derek Murphy, Catherine A Shaw, Jo Dalton, Egle Saviciute, Stephanie Roberts, Janet Harrison, Laura Marsh, Marie Connor, Sophie Halpin, Clare Jackson, Carrol Gamble, Gary Leeming, Murray Wham, Sara Clohisey, Ross Hendry, James Scott-Brown, William Greenhalf, Victoria Shaw, Sarah E McDonald, Seán Keating, Katie A. Ahmed, Jane A Armstrong, Milton Ashworth, Innocent G Asiimwe, Siddharth Bakshi, Samantha L Barlow, Laura Booth, Benjamin Brennan, Katie Bullock, Benjamin WA Catterall, Jordan J Clark, Emily A Clarke, Sarah Cole, Louise Cooper, Helen Cox, Christopher Davis, Oslem Dincarslan, Chris Dunn, Philip Dyer, Angela Elliott, Anthony Evans, Lorna Finch, Lewis WS Fisher, Terry Foster, Isabel Garcia-Dorival, Philip Gunning, Catherine Hartley, Rebecca L Jensen, Christopher B Jones, Trevor R Jones, Shadia Khandaker, Katharine King, Robyn T. Kiy, Chrysa Koukorava, Annette Lake, Suzannah Lant, Diane Latawiec, Lara Lavelle-Langham, Daniella Lefteri, Lauren Lett, Lucia A Livoti, Maria Mancini, Sarah McDonald, Laurence McEvoy, John McLauchlan, Soeren Metelmann, Nahida S Miah, Joanna Middleton, Joyce Mitchell, Ellen G Murphy, Rebekah Penrice-Randal, Jack Pilgrim, Tessa Prince, Will Reynolds, P. Matthew Ridley, Debby Sales, Victoria E Shaw, Rebecca K Shears, Benjamin Small, Krishanthi S Subramaniam, Agnieska Szemiel, Aislynn Taggart, Jolanta Tanianis-Hughes, Jordan Thomas, Erwan Trochu, Libby van Tonder, Eve Wilcock, J. Eunice Zhang, Lisa Flaherty, Nicole Maziere, Emily Cass, Alejandra Doce Carracedo, Nicola Carlucci, Anthony Holmes, Hannah Massey, Lee Murphy, Nicola Wrobel, Sarah McCafferty, Kirstie Morrice, Alan MacLean, Kayode Adeniji, Daniel Agranoff, Ken Agwuh, Dhiraj Ail, Erin L. Aldera, Ana Alegria, Brian Angus, Abdul Ashish, Dougal Atkinson, Shahedal Bari, Gavin Barlow, Stella Barnass, Nicholas Barrett, Christopher Bassford, Sneha Basude, David Baxter, Michael Beadsworth, Jolanta Bernatoniene, John Berridge, Nicola Best, Pieter Bothma, David Chadwick, Robin Brittain-Long, Naomi Bulteel, Tom Burden, Andrew Burtenshaw, Vikki Caruth, Duncan Chambler, Nigel Chee, Jenny Child, Srikanth Chukkambotla, Tom Clark, Paul Collini, Catherine Cosgrove, Jason Cupitt, Maria-Teresa Cutino-Moguel, Paul Dark, Chris Dawson, Samir Dervisevic, Phil Donnison, Sam Douthwaite, Ingrid DuRand, Ahilanadan Dushianthan, Tristan Dyer, Cariad Evans, Chi Eziefula, Chrisopher Fegan, Adam Finn, Duncan Fullerton, Sanjeev Garg, Atul Garg, Effrossyni Gkrania-Klotsas, Jo Godden, Arthur Goldsmith, Clive Graham, Elaine Hardy, Stuart Hartshorn, Daniel Harvey, Peter Havalda, Daniel B Hawcutt, Maria Hobrok, Luke Hodgson, Anil Hormis, Michael Jacobs, Susan Jain, Paul Jennings, Agilan Kaliappan, Vidya Kasipandian, Stephen Kegg, Michael Kelsey, Jason Kendall, Caroline Kerrison, Ian Kerslake, Oliver Koch, Gouri Koduri, George Koshy, Shondipon Laha, Steven Laird, Susan Larkin, Tamas Leiner, Patrick Lillie, James Limb, Vanessa Linnett, Jeff Little, Mark Lyttle, Michael MacMahon, Emily MacNaughton, Ravish Mankregod, Huw Masson, Elijah Matovu, Katherine McCullough, Ruth McEwen, Manjula Meda, Gary Mills, Jane Minton, Mariyam Mirfenderesky, Kavya Mohandas, Quen Mok, James Moon, Elinoor Moore, Patrick Morgan, Craig Morris, Katherine Mortimore, Samuel Moses, Mbiye Mpenge, Rohinton Mulla, Michael Murphy, Megan Nagel, Thapas Nagarajan, Mark Nelson, Matthew K. O'Shea, Igor Otahal, Marlies Ostermann, Mark Pais, Selva Panchatsharam, Danai Papakonstantino, Hassan Paraiso, Brij Patel, Natalie Pattison, Justin Pepperell, Mark Peters, Mandeep Phull, Stefania Pintus, Jagtur Singh Pooni, Frank Post, David Price, Rachel Prout, Nikolas Rae, Henrik Reschreiter, Tim Reynolds, Neil Richardson, Mark Roberts, Devender Roberts, Alistair Rose, Guy Rousseau, Brendan Ryan, Taranprit Saluja, Aarti Shah, Prad Shanmuga, Anil Sharma, Anna Shawcross, Jeremy Sizer, Manu Shankar-Hari, Richard Smith, Catherine Snelson, Nick Spittle, Nikki Staines, Tom Stambach, Richard Stewart, Pradeep Subudhi, Tamas Szakmany, Kate Tatham, Jo Thomas, Chris Thompson, Robert Thompson, Ascanio Tridente, Darell Tupper-Carey, Mary Twagira, Andrew Ustianowski, Nick Vallotton, Lisa Vincent-Smith, Shico Visuvanathan, Alan Vuylsteke, Sam Waddy, Rachel Wake, Andrew Walden, Ingeborg Welters, Tony Whitehouse, Paul Whittaker, Ashley Whittington, Padmasayee Papineni, Meme Wijesinghe, Martin Williams, Lawrence Wilson, Sarah Sarah, Stephen Winchester, Martin Wiselka, Adam Wolverson, Daniel G Wootton, Andrew Workman, Bryan Yates, Peter Young
Publikováno v:
2021, ' Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study : a multicentre, prospective cohort study ', The Lancet Microbe . https://doi.org/10.1016/S2666-5247(21)00090-2
LANCET MICROBE
The Lancet Microbe
E365
E354
investigators, ISARICC & Dark, P 2021, ' Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. ', The Lancet. Microbe, vol. 2, no. 8, pp. e354-e365 . https://doi.org/10.1016/S2666-5247(21)00090-2
The Lancet. Microbe
LANCET MICROBE
The Lancet Microbe
E365
E354
investigators, ISARICC & Dark, P 2021, ' Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. ', The Lancet. Microbe, vol. 2, no. 8, pp. e354-e365 . https://doi.org/10.1016/S2666-5247(21)00090-2
The Lancet. Microbe
Background: Microbiological characterisation of co-infections and secondary infections in patients with COVID-19 is lacking, and antimicrobial use is high. We aimed to describe microbiologically confirmed co-infections and secondary infections, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4445d31672b72cc83c1c5dbecb435d2
https://nottingham-repository.worktribe.com/file/5755939/1/PIIS2666524721000902
https://nottingham-repository.worktribe.com/file/5755939/1/PIIS2666524721000902
Autor:
John McLauchlan, Connor G. G. Bamford
Publikováno v:
Future Virology. 14:125-128
No abstract available.
Autor:
Connor G. G. Bamford, John McLauchlan
Publikováno v:
Bamford, C G G & McLauchlan, J 2021, ' An interferon lambda 4-associated variant in the hepatitis C virus RNA polymerase affects viral replication in infected cells ', Journal of General Virology, vol. 102, no. 2 . https://doi.org/10.1099/jgv.0.001495
Host IFNL4 haplotype status contributes to the development of chronic hepatitis C virus infection in individuals who are acutely infected with the virus. In silico studies revealed that specific amino acid variants at multiple sites on the HCV polypr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603ce0e357764cfa0e14271e50b55401
https://eprints.gla.ac.uk/222349/1/222349.pdf
https://eprints.gla.ac.uk/222349/1/222349.pdf
Autor:
Elihu Aranday-Cortes, Daniel Bradshaw, Anthony Brown, Carmen F. Manso, Brendan Healy, Eleanor Barnes, Jennifer Benselin, Ana da Silva Filipe, Josh Singer, Jean L. Mbisa, David F. Bibby, Emma Hudson, E. Thomson, Phil Troke, M. Azim Ansari, John McLauchlan, William L. Irving, David A. Smith
Sustained viral response (SVR) rates to first-line Direct Acting Antiviral (DAA) therapy for hepatitis C virus (HCV) infection routinely exceed 95%. However, a small number of patients require retreatment. Sofosbuvir, velpatasvir and voxilaprevir (SO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ba0b6aef7eb8f6a8718ff460a9462f8
https://doi.org/10.1101/2020.10.13.20211862
https://doi.org/10.1101/2020.10.13.20211862
Autor:
M A Ansari, Graham S Cooke, Peter Simmonds, L Kuypers, Eleanor Barnes, John McLauchlan, William L. Irving
Mechanisms underlying the ability of hepatitis C virus (HCV) to establish persistent infections and induce progressive liver disease remain poorly understood. HCV is one of several positive-stranded RNA viruses capable of establishing persistence in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a968e3cf259cd3e3f2cbe24f339fae
https://doi.org/10.1101/2020.06.16.155150
https://doi.org/10.1101/2020.06.16.155150
Autor:
Christopher G. Fawsitt, Peter Vickerman, Graham S. Cooke, Nicky J. Welton, Eleanor Barnes, Jonathan Ball, Diana Brainard, Gary Burgess, John Dillon, Graham Foster, Charles Gore, Neil Guha, Rachel Halford, Kevin Whitby, Chris Holmes, Anita Howe, Emma Hudson, Sharon Hutchinson, William Irving, Salim Khakoo, Paul Klenerman, Natasha Martin, Benedetta Massetto, Tamyo Mbisa, John McHutchison, Jane McKeating, John McLauchlan, Alec Miners, Andrea Murray, Peter Shaw, Peter Simmonds, Chris Spencer, Emma Thomson, Nicole Zitzmann
Publikováno v:
Fawsitt, C G, Vickerman, P, Cooke, G S & Welton, N J 2020, ' Cost-Effectiveness Analysis of Baseline Testing for Resistance-Associated Polymorphisms to Optimize Treatment Outcome in Genotype 1 Noncirrhotic Treatment-Naïve Patients With Chronic Hepatitis C Virus ', Value in Health, vol. 23, no. 2, pp. 180-190 . https://doi.org/10.1016/j.jval.2019.08.012
Value in Health
Value in Health
Objectives Direct-acting antivirals containing nonstructural protein 5A (NS5A) inhibitors administered over 8 to 12 weeks are effective in ∼95% of patients with hepatitis C virus. Nevertheless, patients resistant to NS5A inhibitors have lower cure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75b841cd2d913392eb0a841339c92b7
https://research-information.bris.ac.uk/en/publications/d4089c71-044d-413d-a696-78cab971d9ab
https://research-information.bris.ac.uk/en/publications/d4089c71-044d-413d-a696-78cab971d9ab
Autor:
Eleanor Barnes, Nicole Zitzmann, Vanessa M. Cowton, P Simmonds, John F. Dillon, Paolo Piazza, J McLauchlan, P Troke, Sharon J. Hutchinson, E Barnes, C Holmes, Peter Simmonds, Jonathan K. Ball, Chris C. A. Spencer, S Smith, Elihu Aranday-Cortes, Paul Klenerman, David Bonsall, C Gore, Emma Hudson, Natasha K. Martin, Salim I. Khakoo, G R Foster, Amy Trebes, John McLauchlan, William L. Irving, Christopher Holmes, E Hudson, Neil Guha, Jane A. McKeating, P Shaw, E Thomson, Siu Hin Lau, A Murray, Arvind H. Patel, R Halford, Tamyo Mbisa, Graham R. Foster, Graham S Cooke, Ana da Silva Filipe, Kosh Agarwal, W Irving, Peter Vickerman, Vattipally B. Sreenu, P Klenerman, E. Thomson, Alec Miners, Vincent Pedergnana, G Burgess, C Spencer, Camilla L. C. Ip, M. Azim Ansari, Connor G. G. Bamford, Rory Bowden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40bbf620cd5285d88dc68dd523b280f
https://doi.org/10.7554/elife.42463.027
https://doi.org/10.7554/elife.42463.027
Autor:
Eleanor Barnes, Michelle Cheung, John McLauchlan, William L. Irving, Wing-Yiu Jason Lee, David A. Smith, M. Azim Ansari, Connor G. G. Bamford, Meleri Jones, Sampath DaSilva, Peter A.C. Wing, Elihu Aranday-Cortes, Graham R. Foster, Morven Cunningham, Ana da Silva Filipe
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Sofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections and resistance-associated substitutions in the polymerase are rare. However, HCV genotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15381bbbe0a38344b99de9f3ac715c3a
https://ora.ox.ac.uk/objects/uuid:416feebd-d673-4614-9eb1-08d83c47f8f6
https://ora.ox.ac.uk/objects/uuid:416feebd-d673-4614-9eb1-08d83c47f8f6