Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jitender Kumar Bhardwaj"'
Publikováno v:
Ultrastructural Pathology. 45:407-413
The agricultural pesticide poisoning is currently the most thrust area of human health concern. Pesticide-induced cytotoxicity and the corresponding reproductive toxicity in today's scenario is not a concealed reality that has to be considered for th
Publikováno v:
Environmental and Molecular Mutagenesis. 62:374-384
Cadmium (Cd), anenvironmental toxic heavy metal, has been reported to cause testicular toxicity, which contributes to the recent decline in male fertility worldwide. Quercetin (Qcn), a major dietary antioxidant, has been shown to have protective effe
Publikováno v:
Journal of Applied Toxicology. 41:105-117
Cadmium (Cd) is a toxic heavy metal with no known biological functions in the human body. Due to a considerably long biological half-life and very low rate of excretion, accumulation of Cd in different body organs (eg, liver, kidney, and testes) over
Autor:
Monika Ola, Madhulika Bhagat, Jitender Kumar Bhardwaj, Prabodh Chander Sharma, Archana Sharma, Vijay Kumar Thakur, Diksha Sharma, Ramesh K. Goyal
Publikováno v:
Seminars in cancer biology. 86(Pt 3)
It is a major concern to treat cancer successfully, due to the distinctive pathophysiology of cancer cells and the gradual manifestation of resistance. Specific action, adverse effects and development of resistance has prompted the urgent requirement
Publikováno v:
Molecular Reproduction and Development. 86:42-52
Pesticides are known to cause a wide range of reproductive problems that possess degenerative effects on mammalian fertility. Glyphosate (GLP), a broad-spectrum organophosphate herbicide, is known to be a potent mammalian toxicant. The present study
Publikováno v:
Toxin Reviews. 39:1-13
Oxidative stress impairs the female reproductive physiology by altering the affectivity of antioxidant defense system in the individual. Several toxicants mainly pesticides alters this defense syst...
Publikováno v:
Environmental Toxicology. 32:156-166
Methoxychlor (MXC), an organochloride insecticide, is a potent toxicant-targeting female reproductive system and known to cause follicular atresia by inducing apoptosis within granulosa cells. Oxidative stress plays a pivotal role in apoptosis; thus,
Publikováno v:
Journal of biochemical and molecular toxicology. 32(8)
Toxicological studies have demonstrated the relation between use of agrochemicals and fertility issues within males. Thus, the present study aimed to elucidate the propensity of cypermethrin (CYP) in bringing testicular germ cell apoptosis and effect
Autor:
Jitender Kumar Bhardwaj, Navneet Chandak, Dimitrina Zheleva-Dimitrova, Gerassim M. Kitanov, R. K. Sharma, Pawan K. Sharma, Luciano Saso
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 30:722-729
Some of the environmental toxicants acting as endocrine disruptors have been associated with health hazards in human and wildlife by modulating hormonal actions. Atrazine, a strong endocrine disruptor, induces detrimental effects on gonads in male an
Design, Synthesis, and Screening of Triazolopyrimidine-Pyrazole Hybrids as Potent Apoptotic Inducers
Autor:
Raj Kamal, Priyanka Saraf, Vipan Kumar, Vikas Bhardwaj, Priya Kumari, Ravinder Kumar, Jitender Kumar Bhardwaj
Publikováno v:
Archiv der Pharmazie. 350:1700137
An efficient synthesis of novel 3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-5,7-dimethyl-[1,2,4]triazolo[4,3-a]-pyrimidines was accomplished by the oxidation of pyrimidinylhydrazones by using organoiodine(III) reagent. All new triazolopyrimidine derivatives