Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jason K. Sicklick"'
Autor:
Sudeep Banerjee, Robert J. Wechsler-Reya, Jill P. Mesirov, Alexander T. Wenzel, Hyunho Yoon, Huwate Yeerna, Chih-Min Tang, Mayra Yebra, Pablo Tamayo, Stephanie Ting, Jason K. Sicklick
Publikováno v:
Molecular Cancer Therapeutics. 20:2035-2048
Gastrointestinal stromal tumor (GIST) is commonly driven by oncogenic KIT mutations that are effectively targeted by imatinib (IM), a tyrosine kinase inhibitor (TKI). However, IM does not cure GIST, and adjuvant therapy only delays recurrence in high
Autor:
Ryosuke Okamura, Razelle Kurzrock, Justin Shaya, Jason K. Sicklick, Rebecca E. Jimenez, Shumei Kato, Jacob J. Adashek, Suzanna Lee
Publikováno v:
Clinical Cancer Research. 27:2792-2797
Purpose: Cyclin and MAPK/MEK-related gene alterations are implicated in cell-cycle progression and cancer growth. Yet, monotherapy to target the cyclin (CDK4/6) or the MEK pathway has often yielded disappointing results. Because coalterations in cycl
Autor:
Kevin Porras, Mayra Yerba, Paul T. Fanta, Jason K. Sicklick, Pushpa Neppala, Adam M. Burgoyne, Sudeep Banerjee
Publikováno v:
Cancer Metastasis Rev
Gastrointestinal stromal tumors (GISTs) are increasingly recognized as having diverse biology. With the development of tyrosine kinase inhibitors molecularly matched to oncogenic KIT and PDGFRA mutations, GISTs have become a quintessential model for
Autor:
Ethan Sokol, Philip R Cohen, Jason K. Sicklick, Razelle Kurzrock, Alexis Phillips, Huan-You Wang, David C. Fajgenbaum, Aaron M. Goodman, Ah-Reum Jeong
Publikováno v:
Eur J Haematol
Objectives Castleman disease (CD) is a heterogeneous group of disorders involving systemic inflammation and lymphoproliferation. Recently, clonal mutations have been identified in unitcentric CD (UCD) and idiopathic multicentric CD (iMCD), suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50b145115ae47fb0e9ebf302d447d0b
https://europepmc.org/articles/PMC9624446/
https://europepmc.org/articles/PMC9624446/
Autor:
Ryosuke Okamura, Jason K. Sicklick, Joel M. Baumgartner, Lawrence Leichman, Shumei Kato, Hitendra Patel, Scott M. Lippman, Paul T. Fanta, Razelle Kurzrock, Kaitlyn J. Kelly
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 24, iss 24
Purpose: Esophageal, gastroesophageal junction, and gastric adenocarcinoma (herein gastroesophageal adenocarcinomas) are associated with poor prognosis and limited systemic treatment options. To further understand the genomic landscape of gastroesoph
Autor:
Ryosuke Okamura, Shumei Kato, Lyudmila Bazhenova, Jason K. Sicklick, Amélie Boichard, Razelle Kurzrock
Publikováno v:
JCO Precision Oncology. :1-20
Purpose Fusions that involve neurotrophic-tropomyosin receptor kinase ( NTRK) genes are known drivers of oncogenesis. Therapies that target these ultra-rare, constitutionally active NTRK fusions have been remarkably effective. Herein, we analyze the
Autor:
Razelle Kurzrock, Paul T. Fanta, Bryan M. Clary, Jason K. Sicklick, Adam M. Burgoyne, Ryosuke Okamura, Robert J. Mallory, Shumei Kato
Publikováno v:
Int J Cancer
International journal of cancer, vol 148, iss 3
International journal of cancer, vol 148, iss 3
Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers w
Autor:
David S. Hong, Elizabeth Weihe, Rachel Collier, Razelle Kurzrock, Shumei Kato, Jason K. Sicklick, Aaron M. Goodman, Suzanna Lee, Paul Riviere, Ryosuke Okamura, Theresa J. Whitchurch, Manvita Mareboina, Noor Khalid, Gregory A. Daniels, Scott M. Lippman, Paul T. Fanta
Publikováno v:
Int J Cancer
International journal of cancer, vol 146, iss 12
International journal of cancer, vol 146, iss 12
RAS alterations are often found in difficult-to-treat malignancies and are considered "undruggable." To better understand the clinical correlates and coaltered genes of RAS alterations, we used targeted next-generation sequencing (NGS) to analyze 1,9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea43f4f028cad7c44bc975328d220bdd
https://europepmc.org/articles/PMC10200262/
https://europepmc.org/articles/PMC10200262/
Autor:
Lauren Young, Samuel J. Klempner, Jeffrey S. Ross, Bryan Leyland-Jones, Fadi Braiteh, Razelle Kurzrock, Siraj M. Ali, Brady Forcier, Alexa B. Schrock, Vincent A. Miller, Jason K. Sicklick, Allison Welsh, Craig Devoe, Rodolfo Bordoni, Dean Pavlick, Richard D. Carvajal, Jon Chung, Joseph Chao, Philip J. Stephens
Publikováno v:
Clinical Cancer Research. 24:1881-1890
Purpose: Genomic profiling of tumor biopsies from advanced gastrointestinal and anal cancers is increasingly used to inform treatment. In some cases, tissue biopsy can be prohibitive, and we sought to investigate whether analysis of blood-derived cir
Autor:
Chih-Min Tang, Phillippe Foubert, Evangeline Mose, Andrew M. Lowy, Dawn Jaquish, Michele L. Babicky, Megan M. Harper, Alex Cazes, Michael C. Schmid, Karen Messer, Patrick Holman, Randall French, Jaclyn Miyamoto, Susan E. Waltz, Judith A. Varner, Zakkary J Walterscheid, Jeffery Chakedis, Nissi Varki, Hakan Alakus, Betzaira G. Childers, Jason K. Sicklick
Publikováno v:
ONCOGENE
Oncogene, vol 38, iss 28
Oncogene
Oncogene, vol 38, iss 28
Oncogene
The MST1R (RON) kinase is overexpressed in >80% of human pancreatic cancers, but its role in pancreatic carcinogenesis is unknown. In this study, we examined the relevance of Mst1r kinase to Kras driven pancreatic carcinogenesis using genetically eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbd059e2304724657496e421fcd5c30