Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Han Moshage"'
Publikováno v:
Virus research. 263:1-8
Oxidative- and endoplasmic reticulum (ER)-stress are common events during hepatitis C virus (HCV) infection and both regulate cell survival and determine clinical outcome. In response to intrinsic and extrinsic cellular stress, different adaptive mec
Publikováno v:
Antioxidants
Antioxidants, Vol 10, Iss 174, p 174 (2021)
Antioxidants, Vol 10, Iss 174, p 174 (2021)
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of lipid metabolism is closely related to alterations of the oxidant/
Autor:
Klaas Nico Faber, Pieter G. Tepper, Ma Consolación Martínez-Saldaña, Han Moshage, Wim J. Quax, Herson Antonio González-Ponce, Manon Buist-Homan
Publikováno v:
Food Research International, 137:109461. Elsevier
Acetaminophen (APAP) misuse or overdose is the most important cause of drug-induced acute liver failure. Overdoses of acetaminophen induce oxidative stress and liver injury by the electrophilic metabolite N-acetyl-pbenzoquinone imine (NAPQI). Plant-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6064b7b0bc7a125671b38cdae051d89
https://research.rug.nl/en/publications/23cf476c-8630-4ce4-a707-ad060c10b955
https://research.rug.nl/en/publications/23cf476c-8630-4ce4-a707-ad060c10b955
Autor:
Ron T. Gansevoort, Arno R. Bourgonje, Han Moshage, Harry van Goor, Stephan J. L. Bakker, Eline H. van den Berg, Andreas Pasch, Amaal Eman Abdulle, Turtushikh Damba, Svenja Sydor, Hans Blokzijl, Robin P. F. Dullaart
Publikováno v:
Liver International, 40(9), 2148-2159. Wiley
Liver International
Liver International
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation, inflammation and an imbalanced redox homeostasis. We hypothesized that systemic free thiol levels, as a proxy of systemic oxidative stress,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dc7f9fc527817e2ac51dc8193f54e6
https://research.rug.nl/en/publications/fbde2b50-a2ac-4c79-9fc0-f1907e37bc2a
https://research.rug.nl/en/publications/fbde2b50-a2ac-4c79-9fc0-f1907e37bc2a
Autor:
Klaas Nico Faber, Toos Daemen, Han Moshage, W Alfredo Ríos-Ocampo, María Cristina Navas, Manon Buist-Homan
Publikováno v:
Viruses, Vol 12, Iss 425, p 425 (2020)
Viruses
Viruses, 12(4):425. MDPI AG
Volume 12
Issue 4
Viruses
Viruses, 12(4):425. MDPI AG
Volume 12
Issue 4
Hepatitis C virus (HCV) infection is accompanied by increased oxidative stress and endoplasmic reticulum stress as a consequence of viral replication, production of viral proteins, and pro-inflammatory signals. To overcome the cellular stress, hepato
Autor:
W Alfredo Ríos-Ocampo, María Cristina Navas, Manon Buist-Homan, Toos Daemen, Klaas Nico Faber, Han Moshage
Publikováno v:
Redox Report : Communications in Free Radical Research
Redox Report, 24(1), 17-26. Taylor & Francis Ltd
Redox Report, Vol 24, Iss 1, Pp 17-26 (2019)
Redox Report, 24(1), 17-26. Taylor & Francis Ltd
Redox Report, Vol 24, Iss 1, Pp 17-26 (2019)
Objectives: The occurrence of oxidative stress and endoplasmic reticulum (ER) stress in hepatitis C virus (HCV) infection has been demonstrated and play an important role in liver injury. During viral infection, hepatocytes must handle not only the r
Autor:
Juan Pablo Arab, Daniela Reyes, Rolando Sepulveda, Marco Arrese, Nancy Solís, Manon Buist-Homan, Alejandra Hernandez, Han Moshage, Daniel Cabrera, Yana Geng
Publikováno v:
Biochimica et biophysica acta-Molecular basis of disease, 1866(10):165857. ELSEVIER SCIENCE BV
Background The transition from steatosis to non-alcoholic steatohepatitis (NASH) is a key issue in non-alcoholic fatty liver disease (NAFLD). Observations in patients with obstructive sleep apnea syndrome (OSAS) suggest that hypoxia contributes to pr
Autor:
María Consolación Martínez-Saldaña, Ana Rosa Rincón-Sánchez, Herson Antonio González-Ponce, Klaas Nico Faber, María Teresa Sumaya-Martínez, Han Moshage, Fernando Jaramillo-Juárez, Manon Buist-Homan
Publikováno v:
Nutrients, 8(10):607. MDPI AG
Nutrients, Vol 8, Iss 10, p 607 (2016)
Nutrients
Nutrients; Volume 8; Issue 10; Pages: 607
Nutrients, Vol 8, Iss 10, p 607 (2016)
Nutrients
Nutrients; Volume 8; Issue 10; Pages: 607
Acetaminophen (APAP)-induced acute liver failure (ALF) is a serious health problem in developed countries. N-acetyl-L-cysteine (NAC), the current therapy for APAP-induced ALF, is not always effective, and liver transplantation is often needed. Opunti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24bff8e88f314684a786cd2cb6a44ce
https://research.rug.nl/en/publications/45de3f49-e9d6-4adf-af16-63ea4a52b7bc
https://research.rug.nl/en/publications/45de3f49-e9d6-4adf-af16-63ea4a52b7bc
Autor:
Laura Conde de la Rosa, Manon Buist-Homan, Titia E. Woudenberg-Vrenken, Han Moshage, Klaas Nico Faber
Publikováno v:
Liver International. 30:1511-1521
BACKGROUND: Bile acids, reactive oxygen species (ROS) and inflammatory cytokines are crucial regulators of cell death in acute and chronic liver diseases. The contribution of each factor to hepatocyte death, either apoptosis or necrosis, has not been
Autor:
Fernando Jaramillo-Juárez, Ana Rosa Rincón-Sánchez, Han Moshage, Herson Antonio González-Ponce
Publikováno v:
Nutrients
Nutrients, Vol 10, Iss 2, p 117 (2018)
Nutrients, Vol 10, Iss 2, p 117 (2018)
Over-the-counter (OTC) analgesics are among the most widely prescribed and purchased drugs around the world. Most analgesics, including non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen, are metabolized in the liver. The hepatocytes ar