Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Doron Merkler"'
Autor:
Katrin Martin, Daniel D. Pinschewer, Mario Kreutzfeldt, Matias Ciancaglini, Doron Merkler, Florian Geier, Peter Reuther, Diego Calabrese
Publikováno v:
The Journal of experimental medicine. 218(10)
Several RNA viruses can establish life-long persistent infection in mammalian hosts, but the fate of individual virus-infected cells remains undefined. Here we used Cre recombinase–encoding lymphocytic choriomeningitis virus to establish persistent
Autor:
Ingrid Wagner, Giovanni Di Liberto, Doron Merkler, Bogna Klimek, Jonathan Kaye, Nicolas Page, Alexandre Mariotte, Sylvain Lemeille, Ilena Vincenti
Publikováno v:
Nature Communications, Vol. 12, No 1 (2021) P. 1009
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Self-reactive CD8+ T cells are important mediators of progressive tissue damage in autoimmune diseases, but the molecular program underlying these cells’ functional adaptation is unclear. Here we characterize the transcriptional and epigenetic land
Autor:
Mario Kreutzfeldt, Melanie Greter, Doron Merkler, Ingrid Wagner, Noushin Hadadi, Ilena Vincenti, Mary-Aude Rochat, Martina Spiljar, Nicolas Page, Mirko Trajkovski, Ozren Stojanović, Matthias Mack, Bogna Klimek, Dilay Cansever, Claire Chevalier, Nicolas Suárez-Zamorano, Dorothée Rigo, Karin Steinbach
SUMMARYAutoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6Chi monocytes are key effectors in CNS autoimmunity with elusive role in priming naïve autoreactive T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d4bc2a547c16771095b00097357fbad
https://doi.org/10.1101/2020.08.28.269563
https://doi.org/10.1101/2020.08.28.269563
Autor:
Nicolas Page, Doron Merkler, Ingrid Wagner, Mario Kreutzfeldt, Mary-Aude Rochat, Claire Chevalier, Dilay Cansever, Olivia Bejuy, Karin Steinbach, Nicolas Suárez-Zamorano, Martina Spiljar, Didier J. Colin, Ilena Vincenti, Ozren Stojanović, Mirko Trajkovski, Matthias Mack, Noushin Hadadi, Bogna Klimek, Dorothée Rigo, Melanie Greter
Publikováno v:
Cell Metabolism
Cell metabolism, Vol. 33, No 11 (2021) pp. 2231-2246.e8
Cell metabolism, Vol. 33, No 11 (2021) pp. 2231-2246.e8
Summary Autoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6Chi monocytes are key effectors in CNS autoimmunity with an elusive role in priming naive autoreactiv
Publikováno v:
Microorganisms, Vol. 9, No 3 (2021) P. 564
Microorganisms
Microorganisms, Vol 9, Iss 564, p 564 (2021)
Microorganisms
Microorganisms, Vol 9, Iss 564, p 564 (2021)
Arenaviruses such as Lassa virus cause arenavirus hemorrhagic fever (AVHF), but protective vaccines and effective antiviral therapy remain unmet medical needs. Our prior work has revealed that inducible nitric oxide synthase (iNOS) induction by IFN-
Autor:
Nicolas Page, Irène Rossitto-Borlat, Thomas Korn, Christine Stadelmann, Mario Kreutzfeldt, Kristof Egervari, Bogna Klimek, Oliver Hartley, Ilena Vincenti, Andreas Muschaweckh, Franziska van der Meer, Doron Merkler, Karin Steinbach, Ingrid Wagner, Karim Hammad, Daniel D. Pinschewer, Giovanni Di Liberto
Publikováno v:
Science Translational Medicine, Vol. 11, No 498 (2019) P. eaav5519
Epidemiological studies associate viral infections during childhood with the risk of developing autoimmune disease during adulthood. However, the mechanistic link between these events remains elusive. We report that transient viral infection of the b
Autor:
Moatasem El-Ayadi, Kristof Egervari, Doron Merkler, Thomas A. McKee, Fabienne Gumy-Pause, Damian Stichel, David Capper, Torsten Pietsch, Marc Ansari, André O. von Bueren
Publikováno v:
Frontiers in Neurology, Vol. 9 (2018) P. 398
Frontiers in Neurology
Frontiers in Neurology, Vol 9 (2018)
Frontiers in Neurology
Frontiers in Neurology, Vol 9 (2018)
Isocitrate Dehydrogenase-1 (IDH1) is a driver gene in several cancers including brain tumors such as low-grade and high-grade gliomas. Mutations of SMARCB1 were described in atypical teratoid rhabdoid tumors and to date have not been associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad27b52b54750461a781bb29bf3aee50
https://archive-ouverte.unige.ch/unige:109372
https://archive-ouverte.unige.ch/unige:109372
Autor:
Lukas Flatz, Beat A. Kaufmann, Tommy Regen, Toni Rieger, Lukas Bestmann, Mario Kreutzfeldt, Benedict Fallet, Daniel D. Pinschewer, Melissa Remy, Uwe-Karsten Hanisch, Doron Merkler, Lifen Xu, Camille Doras, Mehmet Sahin
Publikováno v:
Cell Host & Microbe, Vol. 22, No 3 (2017) pp. 354-365.e5
Arenaviruses such as Lassa virus (LASV) cause hemorrhagic fever. Terminal shock is associated with a systemic cytokine storm, but the mechanisms are ill defined. Here we used HLA-A2-expressing mice infected with a monkey-pathogenic strain of lymphocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f37c1da7d6faa6ee200398aa4eeab2
https://archive-ouverte.unige.ch/unige:98394
https://archive-ouverte.unige.ch/unige:98394
Autor:
Ingrid Wagner, Sylvain Lemeille, Gabriela Salinas, Ilena Vincenti, Bogna Klimek, Jonathan Kaye, Daniel D. Pinschewer, Karin Steinbach, Mikael Simons, Thomas Lingner, Rabih Murr, Dietmar Zehn, Hadrien Soldati, Doron Merkler, Wolfgang Brück, Nicolas Page, Mario Kreutzfeldt, Giovanni Di Liberto, Mathias De Roo
Publikováno v:
Immunity, Vol. 48, No 5 (2018) pp. 937-950.e8
Immunity, Vol. 50, No 3 (2019) P. 763
Immunity 48(5), 937-950.e8 (2018). doi:10.1016/j.immuni.2018.04.005
Immunity, Vol. 50, No 3 (2019) P. 763
Immunity 48(5), 937-950.e8 (2018). doi:10.1016/j.immuni.2018.04.005
Infections are thought to trigger CD8(+) cytotoxic T lymphocyte (CTL) responses during autoimmunity. However, the transcriptional programs governing the tissue-destructive potential of CTLs remain poorly defined. In a model of central nervous system
Autor:
Ngoc Lan Tran, Mario Kreutzfeldt, Marie-Laure Santiago-Raber, Patrice H. Lalive, Doron Merkler, Mahdia Benkhoucha
Publikováno v:
European Journal of Immunology. 44:46-57
The innate Toll-like receptor 7 (TLR7) detects infections by recognizing viral and bacterial single-stranded RNA. In addition to pathogen-derived RNA, immune cells expressing high levels of TLR7, such as B cells and dendritic cells (DCs), can be acti