Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dawang Zhou"'
Autor:
Zhang Jingfang, Yunzhan Li, Zhenzhen Fan, Zhuang Zhongji, Li Li, Ting Zhang, Dawang Zhou, Sun Xihuan, Xianming Deng, Liu Yan, Fu Gui, Deng Zhou, Jie Jiang, Su-Jie Zhu, Huang Xiaoxing, Yue Lu, Siyang Song, Jianming Zhang, Xuehui Hong, Zhang Baoding, Qiao Wu, Lanfen Chen, Wei Huang, Xin Huang, Cai-Hong Yun, Qiyuan Li, Liang Chen, Lei Gao, Zheng Wang
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 1, Pp n/a-n/a (2022)
EMBO Molecular Medicine
EMBO Molecular Medicine
More than 60% of nonsmall cell lung cancer (NSCLC) patients show a positive response to the first ALK inhibitor, crizotinib, which has been used as the standard treatment for newly diagnosed patients with ALK rearrangement. However, most patients ine
Autor:
Dawang Zhou, Shihao Zhang
Publikováno v:
Current Opinion in Cell Biology. 61:64-71
Liver cancer, hepatocellular carcinoma (HCC) in particular, is one of the deadliest cancers worldwide. Although the etiologies for liver oncogenesis are relatively well defined, the exact mechanisms leading to cancer development remain elusive. The H
Autor:
Fei Chen, Dawang Zhou, Jiancheng Ding, Wen Liu, Aicun Li, Lei Zhang, Han You, Zhe Meng, Zhicheng Gong, Ronggui Hu, Yuanpei Li, Jialiang Huang, Qing Li, Jing Ye
Publikováno v:
Advanced Science
Advanced Science, Vol 8, Iss 15, Pp n/a-n/a (2021)
Advanced Science, Vol 8, Iss 15, Pp n/a-n/a (2021)
Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST/
Autor:
Kang Cheng, Dawang Zhou, Yuan-li Ai, Hang-zi Chen, Ru-yue Sun, Jiahuai Han, Jia-yuan Zhang, Bo Zhou, Xian-shuo Liu, Qiao Wu
Publikováno v:
Cell Research
Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death, such as ferroptosis, apoptosis and necroptosis. However, whether iron-elevated ROS is also linked to pyrop
Autor:
Pei-pei Hou, Sheng-fu Wu, Dawang Zhou, Wenxiu Zhao, Jianming Liu, Qiao Wu, Hang-zi Chen, Xiaomin Wang, Li-juan Luo, Lu-ming Yao, Qinghua Chen, Xue-li Bian, Zhi-yuan Zhang, Jia-xin Zhou, Qi-tao Chen
Publikováno v:
Molecular cell. 78(6)
Tumor-derived extracellular vesicles are important mediators of cell-to-cell communication during tumorigenesis. Here, we demonstrated that hepatocellular carcinoma (HCC)-derived ectosomes remodel the tumor microenvironment to facilitate HCC progress
Autor:
Lanfen Chen, Han You, Zengqiang Yuan, Jing Geng, Yiran Shi, Yueyue Linghu, Jau-Song Yu, Ping Wang, Jiahui Gao, Xun Li, Dawang Zhou, Randy L. Johnson, Chen Xiao, Hao Zhao, Bingying Yang, Junhong Li, Xiufeng Sun, Funiu Qin, Xin Chen, Lixin Hong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism against pathogens. However, the cellular self-protective mechanism against such potential damage from oxidative stress remains unclear. Here we show that the kinases
Publikováno v:
Acta Biochimica et Biophysica Sinica. 47:46-52
The Hippo signaling pathway is an evolutionarily conserved signaling module that plays critical roles in liver size control and tumorigenesis. The Hippo pathway consists of a core kinase cascade in which the mammalian Ste20-like kinases (Mst1/2, orth
Autor:
Suyuan Ji, Daming Gao, Chengyan Liu, Dawang Zhou, Qiao Wu, Keiko Nakayama, Jing Geng, Qiyuan Li, Lixin Hong, Shihao Zhang, Xianming Deng, Kwang Huei Lin, Keiichi I. Nakayama, Yuanyuan Zeng, Lanfen Chen, Qingxu Liu, Qinghua Chen, Weiji Zhang, Liang Zhu, Zhonglei Lu, Zhenyu Yin, Xiufeng Sun, Randy L. Johnson, Yuxi Li
Polyploidy can lead to aneuploidy and tumorigenesis. Here, we report that the Hippo pathway effector Yap promotes the diploid-polyploid conversion and polyploid cell growth through the Akt-Skp2 axis. Yap strongly induces the acetyltransferase p300-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b749080e45476fc11c8cb09259ba2a
https://europepmc.org/articles/PMC5863541/
https://europepmc.org/articles/PMC5863541/
Autor:
Weichao Ding, Dawang Zhou, Hong-Rui Wang, Jieying Fu, Jing Bi, Binfeng Lu, Meilin Wang, Taoling Zeng, Zhenyu Yin, Xianming Deng, Wenxiu Zhao, Sheng Zhang, Yikai Qiao, Huayue Lin, Qi Lin, Qun Wang
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 871-882 (2014)
SummaryRAS genes are among the most frequently mutated proto-oncogenes in cancer. However, how Ras stability is regulated remains largely unknown. Here, we report a regulatory loop involving the E3 ligase Nedd4-1, Ras, and PTEN. We found that Ras sig
Autor:
Xin Chen, Jiahuai Han, Yingying Zhang, Yaoji Liang, Shimin Zhao, Chuan-Qi Zhong, Xia-Di He, Jianfeng Wu, Hengxiao Ni, Dawang Zhou, Yan Wang, Zhentao Yang
Publikováno v:
Nature cell biology. 20(2)
Receptor-interacting protein kinase 3 (RIP3)-regulated production of reactive oxygen species (ROS) positively feeds back on tumour necrosis factor (TNF)-induced necroptosis, a type of programmed necrosis. Glutamine catabolism is known to contribute t