Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Yutaka Yoshikawa"'
Publikováno v:
Biological Trace Element Research. 192:206-213
The risk of serious complication gradually increases as diabetes mellitus (DM) progresses. Thus, strategies for the prevention and delay of symptom progression are urgently needed. Previously, we synthesized zinc (Zn) complexes estimated to have a hi
Autor:
Syoko Ino, Chihiro Ueno, Aya Itoi, Norihiro Sakamoto, Naoko Ikuta, Nanako Nihei, Keiji Terao, Yutaka Yoshikawa, Hinako Okamoto
Publikováno v:
Journal of Clinical Biochemistry and Nutrition. 65:99-108
4-Methylthio-3-butenyl isothiocyanate (MTBI) is a pungent bioactive constituent found in daikon. However, MTBI is immediately hydrolyzed to 3-hydroxy-methylene-2-thioxopyrrolidine in grated daikon. In this study, we evaluated whether MTBI in grated d
Autor:
Yutaka Yoshikawa, Hiroyuki Yasui, Michiko Shintani, Yuki Naito, Shingo Kamoshida, Naemi Kajiwara
Publikováno v:
Biological & Pharmaceutical Bulletin. 40:318-326
Zinc (Zn) is a trace element with anti-diabetes mellitus (anti-DM) effects. Zn complexes exhibit stronger insulin-like activity than Zn ions. Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) was recently reported to be a potent anti-DM candidate. We exami
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2647 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2647
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2647
International Journal of Molecular Sciences
Since the discovery of the anti-diabetic effects of zinc (Zn) complex, we synthesized several Zn complexes and evaluated their effects using the KKAy type 2 diabetes mouse model. Recently, we demonstrated that organo-chalcogen (sulfur and selenium) Z
Publikováno v:
In vivo (Athens, Greece). 31(6)
Background/aim Metabolic syndrome-induced lifestyle-related diseases include diabetes mellitus (DM) and hypertension, and Zn-based compounds have effects on DM. We aimed to investigate the ameliorating effects of bis(hinokitiolato)Zn, [Zn(hkt)2] on l
Autor:
Shiliang Li, Matthias Karck, Gábor Szabó, Ayhan Atmanli, E Barnucz, Yutaka Yoshikawa, Kristóf Hirschberg, Sivakkanan Loganathan, Sevil Korkmaz, Tamás Radovits, Hiroyuki Yasui, Péter Hegedűs
Publikováno v:
Experimental Biology and Medicine. 240:1247-1255
The pathophysiology of ischemic myocardial injury involves cellular events, reactive oxygen species, and an inflammatory reaction cascade. The zinc complex of acetylsalicylic acid (Zn(ASA)2) has been found to possess higher anti-inflammatory and lowe
Autor:
Naemi Kajiwara, Daisuke Nakata, Yuki Naito, Yutaka Yoshikawa, Hiroyuki Yasui, Keiji Terao, Ayaka Okano, Kinuyo Matsumoto, Naoko Ikuta
Publikováno v:
Journal of Clinical Biochemistry and Nutrition
In recent years, the number of patients suffering from diabetes mellitus has been increasing worldwide. In particular, type 2 diabetes mellitus, a lifestyle-related disease, is recognized as a serious disease with various complications. Many types of
Publikováno v:
Metallomics. 6:1632-1638
The relationship between biometals, such as zinc (Zn(2+)), vanadium, copper, cobalt, and magnesium ions, and diabetes therapy has been recognized for several years. In particular, the antidiabetic activities of Zn(2+) and oxovanadium (VO(2+)) complex
Publikováno v:
Journal of Toxicologic Pathology. 26:329-333
Vanadium has potential for use in diabetes therapy. Many investigators have reported toxic effects of inorganic vanadium salts; however, there are few reports on toxic effects of oxovanadium(VO2+) complexes. Therefore, we studied VO2+ toxicity by exa
Autor:
Hirotaka Nagai, Norihiko Kohyama, Seishiro Hirano, Li Jiang, Shinya Toyokuni, Hiroyuki Yasui, Yoriko Yamashita, Yasumasa Okazaki, Katsuya Ikuta, Yasushi Shinohara, Hiroki Ohara, Takashi Takahashi, Shinya Akatsuka, Yutaka Yoshikawa, Katsunori Sasaki, Yutaka Kohgo, Shan-Hwu Chew
Publikováno v:
The Journal of Pathology. 228:366-377
Exposure to asbestos is a risk for malignant mesothelioma (MM) in humans. Among the commercially used types of asbestos (chrysotile, crocidolite, and amosite), the carcinogenicity of chrysotile is not fully appreciated. Here, we show that all three a