Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Molecular‐targeted therapies have demonstrated disappointing results against most advanced solid cancers. This may largey be attributed to irrational drug use against unselected cancers. We investigated the efficacy of dual MEK‐PI3K drug therapy
Publikováno v:
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-13 (2020)
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-13 (2020)
Background Mucinous colon cancers (MCC) are characterized by abundant production of mucin 2 (MUC2) protein and are less sensitive to standard systemic chemotherapy. We postulated that severe/persistent endoplasmic reticulum stress (ERS) aggravation i
Autor:
Lesley M. Foley, Hima Makala, Haroon A. Choudry, Robin Frederick, Ashok K. Dilly, Jianxia Guo, David L. Bartlett, Jan H. Beumer, T. Kevin Hitchens, Yong J. Lee, Brendon D. Honick, Anuleka Elapavaluru, Lora H. Rigatti, Sachin Velankar
Publikováno v:
Transl Res
Abundant intraperitoneal (IP) accumulation of extracellular mucus in patients with appendiceal mucinous carcinoma peritonei (MCP) causes compressive organ dysfunction and prevents delivery of chemotherapeutic drugs to cancer cells. We hypothesized th
Autor:
Yong J. Lee, Chuanyue Wu, Se Hoon Hong, David L. Bartlett, Seog Young Kim, Yong Tae Kwon, Per H. Basse
Publikováno v:
Journal of Cellular Biochemistry. 117:2289-2301
Cancer stem cells (CSCs) are capable of initiation and metastasis of tumors. Therefore, understanding the biology of CSCs and the interaction between CSCs and their counterpart non-stem cells is crucial for developing a novel cancer therapy. We used
Autor:
Eun Kyung Lee, Seul Gi Yoon, Chang Sik Choi, Hanho Shin, Dong H. Son, Jung Hyuck Park, Ki Woo Kim, Jung Eun Kim, Jun Gi Rho, Wook Kim, Ji H. Han, Juhwan Yoon, Je K. Seong, Il Yong Kim, Byung Joo Song, Yong J. Lee
Publikováno v:
Diabetes, obesitymetabolism. 20(9)
Aim To analyze the metabolic parameters and adipose tissue inflammation via NLRP3 inflammasome following chronic treatment of mouse models of obesity with AJ5018 as the peripherally restricted cannabinoid 1 receptor (CB1R) antagonist. Materials and m
Autor:
Herbert J. Zeh, Yong J. Lee, Haroon A. Choudry, Brendon D. Honick, Z S Guo, David L. Bartlett, Ashok K. Dilly
Publikováno v:
Oncotarget
// Ashok K. Dilly 1 , Brendon D. Honick 1 , Yong J. Lee 1, 2 , Zong S. Guo 1 , Herbert J. Zeh 1 , David L. Bartlett 1 and Haroon A. Choudry 1 1 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh PA 15232, USA 2 Department of P
Autor:
Joonsung Hwang, Sang Cheul Oh, Shin Hyuk Kang, Ki Sa Sung, Dae Hee Lee, Su Ran Mun, Hyungsin Kim, Young Dong Yoo, Changhoon Ji, Seong Hye Park, Kyung Jae Park, Deric M. Park, Yong J. Lee, Seung-Ki Kim, Kim Bo Yeon, Seung Ah Choi, Aaron Ciechanover, Yong Tae Kwon, Hyunjoo Cha-Molstad
Although proteasome inhibitors (PIs) are used as anticancer drugs to treat various cancers, their relative therapeutic efficacy on stem cells vs. bulk cancers remains unknown. Here, we show that stem cells derived from gliomas, GSCs, are up to 1,000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034fb9c71b3cc892afa2853f84d3f13c
https://europepmc.org/articles/PMC5210095/
https://europepmc.org/articles/PMC5210095/
Publikováno v:
Molecular Cancer Research. 10:1567-1579
Colorectal cancer is the third leading cause of cancer-related mortality in the world. The main cause of death because of colorectal cancer is hepatic metastases, which can be treated using isolated hepatic perfusion (IHP), allowing treatment of colo
Publikováno v:
Journal of Clinical Biochemistry and Nutrition
Astaxanthin (ATX), a naturally occurring carotenoid pigment, is a powerful biological antioxidant. In the present study, we investigated whether ATX pharmacologically offers neuroprotection against oxidative stress by cerebral ischemia. We found that
Autor:
Marco A. Alcala, Jinsang Yoo, David L. Bartlett, Byeong-Chel Lee, Bae-Hang Park, Dae Hee Lee, Kyung Soo Park, Yong J. Lee
Publikováno v:
Journal of Cellular Biochemistry. 110:1073-1081
Approximately 25% of patients with colorectal cancer develop metastases to the liver, and surgery is currently the best treatment available. But there are several patients who are unresectable, and isolated hepatic perfusion (IHP) offers a different