Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Xiawei Wei"'
Autor:
Xiawei Wei, An Tong, Yang Yang, Ruyu Pi, Xia Zhao, Tianqi Lu, Xiaoyi Hu, Houhui Shi, Hongyi Li, Yuquan Wei, Xi Wang, Yu Liu
Publikováno v:
Cancer Letters. 523:72-81
Mechanistic target of rapamycin (mTOR) forms two distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. Here we investigated the antitumor effect of dual mTORC1/2 inhibitor AZD2014 on epithelial ovarian cancer (EOC) and its potential effect on immun
Publikováno v:
MedComm, Vol 2, Iss 4, Pp 531-547 (2021)
MedComm
MedComm
The number of coronavirus disease 2019 (COVID‐19) cases has been increasing significantly, and the disease has evolved into a global pandemic, posing an unprecedented challenge to the healthcare community. Angiotensin‐converting enzyme 2, the bin
Publikováno v:
Nano Research. 15:2177-2195
The immunosuppressive tumor microenvironment (TME) is crucial in the occurrence of tumorigenesis, metastasis, and drug resistance. Among all stromal cells, tumor-associated macrophages (TAMs) are recognized as vital components causing the TME to be f
Autor:
Haiying Que, Xiawei Wei, Li Chen, Tianxia Lan, Yuquan Wei, Jingyun Yang, Cai He, Dandan Wan, Weiqi Hong
Publikováno v:
Nano Letters. 21:7960-7969
Toll-like receptor (TLR) agonists as the potent stimulants of an innate immune system hold promises for applications in anticancer immunotherapy. However, most of them are limited in the clinical translation due to the uncontrolled systemic inflammat
Publikováno v:
Cellular and Molecular Life Sciences. 78:6823-6850
Metastasis is the main culprit of cancer-associated mortality and involves a complex and multistage process termed the metastatic cascade, which requires tumor cells to detach from the primary site, intravasate, disseminate in the circulation, extrav
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3935-3949 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3935-3949 (2021)
A significant proportion of non-small cell lung cancer (NSCLC) patients experience accumulating chemotherapy-related adverse events, motivating the design of chemosensitizating strategies. The main cytotoxic damage induced by chemotherapeutic agents
Publikováno v:
Molecular Biomedicine, Vol 2, Iss 1, Pp 1-12 (2021)
Molecular Biomedicine
Molecular Biomedicine
Acute liver injury is a common but urgent clinical condition, and its underlying mechanism remains to be further elucidated. Concanavalin A (ConA)-induced liver injury was investigated in the study. Different from the caspase-dependent cell apoptosis
Autor:
Xiawei Wei, Qinqin Pu, Erxi Wu, Ping Lin, Shugang Qin, Chuanmin Zhou, Nadeem Khan, Min Wu, Pan Gao, Zhenwei Xia, Biao Wang, Kai Guo, Zhihan Wang
Publikováno v:
J Immunol
Gut microbiota is increasingly linked to the development of various pulmonary diseases through a gut–lung axis. However, the mechanisms by which gut commensal microbes impact trafficking and functional transition of immune cells remain largely unkn
Publikováno v:
MedComm, Vol 2, Iss 2, Pp 279-287 (2021)
MedComm
MedComm
Alveolar epithelial cells (ACEs) gradually senescent as aging, which is one of the main causes of respiratory defense and function decline. Investigating the mechanisms of ACE senescence is important for understanding how the human respiratory system
Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Autor:
Yuan Cheng, Xuejiao Han, Qingfang Li, Fei Mo, Xiawei Wei, Yuquan Wei, Houhui Shi, Siyuan Chen
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-21 (2021)
Molecular Cancer
Molecular Cancer
Background Drug-resistance and severe side effects of chemotherapeutic agents result in unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role in progression of cancer including lung cancer. However, the specific