Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Wei-Yi Ong"'
Autor:
Sneha Muralidharan, Long N. Nguyen, Thiet Minh Vu, Juat Chin Foo, Aaron Wei Liang Li, Mark Y. Chan, Toan Quoc Nguyen, Zafrul Hasan, Sang-Ha Baik, Madhuvanthi Chandrakanthan, Wei-Yi Ong, Amaury Cazenave-Gassiot, Markus R. Wenk, Sock Hwee Tan, Uyen Thanh Nha Le, Hoa Thi Thuy Ha, Federico Torta
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
We recently discovered that Mfsd2b, which is the S1P exporter found in blood cells. Here, we report that Mfsd2b is critical for the release of all S1P species in both resting and activated platelets. We show that resting platelets store S1P in the cy
Autor:
Venetia Kok Jing Tong, Sylvester Wong Shu Ming, Kah-Leong Lim, Ziyin Wang, Rafhanah Banu Bte Abdul Razar, Saravanan Gunaseelan, Sumitra Srimasorn, Wei-Yi Ong, John Jia En Chua
Publikováno v:
Human Molecular Genetics. 30:5-20
FEZ1-mediated axonal transport plays important roles in central nervous system development but its involvement in the peripheral nervous system is not well-characterized. FEZ1 is deleted in Jacobsen syndrome (JS), an 11q terminal deletion development
Autor:
Wei-Yi Ong, Deron R. Herr, Christopher P Chen, Mitchell K.P. Lai, Brenda Wan Shing Lam, Leona Ting Yuke Ho, Wee Siong Chew, Xin Ying Chua, Ping Xiang
Publikováno v:
NeuroMolecular Medicine. 23:47-67
Sphingosine 1-phosphates (S1Ps) are bioactive lipids that mediate a diverse range of effects through the activation of cognate receptors, S1P1-S1P5. Scrutiny of S1P-regulated pathways over the past three decades has identified important and occasiona
Publikováno v:
Molecular Neurobiology
The SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also the central nervous system (CNS)—as seen by effects on smell, taste, seizures, stroke, ne
Autor:
Peiyan Wong, Wei Lun Seow, Wee Siong Chew, Deron R. Herr, Wei Wang, Federico Torta, Wei-Yi Ong, Ping Xiang, Jing Kai Chang, Raghav Sundar, Aishwarya Bandla, Markus R. Wenk, Brenda Wan Shing Lam, Kanokporn Chayaburakul, Violeta Lopez
Publikováno v:
Journal of Biological Chemistry. 295:1143-1152
Platinum-based therapeutics are used to manage many forms of cancer, but frequently result in peripheral neuropathy. Currently, the only option available to attenuate chemotherapy-induced neuropathy is to limit or discontinue this treatment. Sphingos
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Publikováno v:
Molecular Neurobiology. 57:372-392
Autotaxin (ATX) is a soluble extracellular enzyme that is abundant in mammalian plasma and cerebrospinal fluid (CSF). It has two known enzymatic activities, acting as both a phosphodiesterase and a phospholipase. The majority of its biological effect
Publikováno v:
Molecular Neurobiology
The prefrontal cortex (PFC) is not only important in executive functions, but also pain processing. The latter is dependent on its connections to other areas of the cerebral neocortex, hippocampus, periaqueductal gray (PAG), thalamus, amygdala, and b
Publikováno v:
Molecular Neurobiology
The Traditional Chinese Medicine (TCM) theory that “kidneys give rise to marrow, and the brain is the sea of marrow” has been a guide for the clinical application of kidney, qi and blood tonics for prevention and treatment of dementia and improve
Publikováno v:
Neurochemistry International. 146:105018
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid which modulates vascular integrity through its receptors, S1P1-S1P5. Notably, S1P2 has been shown to mediate the disruption of cerebrovascular integrity in vitro and in vivo. However, the mech