Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Vincent W. Keng"'
Autor:
Eunice Y. Lau, Man Tong, Katherine Po Sin Chung, Terence K. Lee, Stephanie Ma, Rainbow Wing Hei Leung, Etienne H. Mok, Irene Oi-Lin Ng, Martina Mang Leng Lei, Q Zhao, Vincent W. Keng, Carmen Oi Ning Leung, Hoi Wing Leung, Cong Ma
Publikováno v:
Cancer Research. 81:3229-3240
The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer stem cells (CSC) is a possible way to reverse drug resistance, however, inhibitors that spec
Publikováno v:
Biochemical and Biophysical Research Communications. 541:70-77
A forward genetic Sleeping Beauty (SB) insertional mutagenesis screen, followed by high-throughput transcriptome sequencing, was used to identify driver genes responsible for hepatocellular carcinoma (HCC)-associated metastasis. Using RNA-sequencing
Autor:
Lilian H. Lo, Shi Jie Zhang, David A. Largaespada, Xiao Xiao Li, Xin Yi Lu, Vincent W. Keng, Qu Bo Chen, Amy P. Chiu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss, Pp 68-75 (2019)
Non-alcoholic fatty liver disease (NAFLD) is becoming an epidemic disease in adults and children worldwide. Importantly, there are currently no approved treatments available for NAFLD. This study aims to investigate the potential applications of sodi
Autor:
He Ning Cui, Xiao Xiao Li, Lilian H. Lo, Shi Jie Zhang, Dewi Kenneth Rowlands, Jeffery C. To, Vincent W. Keng, Amy P. Chiu
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 1, Pp 297-303 (2019)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
The neuromuscular junction (NMJ) consists of three components, namely presynaptic motor neurons, postsynaptic muscle fibers and perisynaptic Schwann cells (PSCs). The role of Schwann cells (SCs) in regulating NMJ structural and functional development
Autor:
Xiao-Xiao Li, Jian Huang, Dewi Kenneth Rowlands, Shi Jie Zhang, Lilian H. Lo, Amy P. Chiu, Vincent W. Keng, Jinhui Wang
Publikováno v:
Cancer Medicine. 7:4791-4800
Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive form of soft tissue neoplasm with extremely poor prognosis and no effective medical options currently available. MPNSTs can occur either sporadically or in association with the neuro
Autor:
Lewis R. Roberts, Robert Hullsiek, Lindsey A. Lee, Wendy A. Hudson, Barbara R. Tschida, Timothy P. Kuka, Michael A. Linden, Vincent W. Keng, Sandra Wagner, David A. Largaespada, Rachel A. Heuer, Pauline J. Beckmann, Nuri A. Temiz, Khalid Amin, Jesse D. Riordan, Joseph H. Nadeau, Ju Dong Yang, Adam J. Dupuy, Carlos A. Tierrablanca, Aaron L. Sarver
Publikováno v:
Cancer Research. 77:6576-6588
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using Sleeping Beauty
Autor:
David A. Largaespada, Roser Pinyol, Bryant J. Keller, Barbara R. Tschida, Nuri A. Temiz, Helena Cornella, Timothy P. Kuka, Juan E. Abrahante, Michael A. Linden, Nicholas Koes, Khalid Amin, Gabriel Kaufmann, Germán L. Vélez-Reyes, Caitlin B. Conboy, Josep M. Llovet, Hsiangyu Hu, Vincent W. Keng, Clara Alsinet, Timothy K. Starr
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in developm
Autor:
Amy P. Chiu, Vincent W. Keng
Publikováno v:
Methods in Molecular Biology ISBN: 9781493989669
Understanding the complex genetic background of cancers is key in developing effective targeted therapies. The Sleeping Beauty (SB) transposon system is a powerful and unbiased genetic editing tool that can be used for rapid screening of candidate li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d62b43d243d2ac1f6904fb7796aadb6
https://doi.org/10.1007/978-1-4939-8967-6_15
https://doi.org/10.1007/978-1-4939-8967-6_15
Autor:
Adam J. Dupuy, Barbara R. Tschida, Vincent W. Keng, David A. Largaespada, Khalid Amin, Christopher S. Stipp, Pauline J. Beckmann, Charlotte R. Feddersen, Michael A. Linden, Jesse D. Riordan
Most hepatocellular carcinomas (HCCs) develop in a chronically injured liver, yet the extent to which this microenvironment promotes neoplastic transformation or influences selective pressures for genetic drivers of HCC remains unclear. We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e536d52d60f1ab77cc1c53064e4ec808
https://europepmc.org/articles/PMC5826818/
https://europepmc.org/articles/PMC5826818/
Publikováno v:
Seminars in Cell & Developmental Biology. 27:86-95
The genetic complexity and heterogeneity of cancer has posed a problem in designing rationally targeted therapies effective in a large proportion of human cancer. Genomic characterization of many cancer types has provided a staggering amount of data