Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ulf R, Rapp"'
Autor:
Viktor Wixler, Dörthe Masemann, Ramona Meissner, Tanja Schied, Ulf R. Rapp, Brian D. Lichty, Stephan Ludwig
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Oncoimmunology
article-version (VoR) Version of Record
Oncoimmunology
article-version (VoR) Version of Record
Non-small cell lung cancers (NSCLCs) establish a highly immunosuppressive tumor microenvironment supporting cancer growth. To interfere with cancer-mediated immunosuppression, selective immune-checkpoint inhibitors (ICIs) have been approved as a stan
Autor:
Nefertiti El-Nikhely, Soni Savai Pullamsetti, Friedrich Grimminger, Ulf R. Rapp, Indrabahadur Singh, Astrid Wietelmann, Andreas Weigert, Annika Karger, Guillermo Barreto, Reinhard Dammann, Poonam Sarode, Werner Seeger, Ludger Fink, Rajkumar Savai, Thorsten Stiewe
Publikováno v:
Cancer Research
Cancer Research, American Association for Cancer Research, 2020, 80 (19), pp.4199-4211. ⟨10.1158/0008-5472.CAN-20-1158⟩
Cancer Research, American Association for Cancer Research, 2020, 80 (19), pp.4199-4211. ⟨10.1158/0008-5472.CAN-20-1158⟩
Although NF-κB is known to play a pivotal role in lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenetic regulation of NF-κB in tumor context is largely unknown. Here we report that the IKK2/NF-κB sig
Publikováno v:
Oncotarget
Identifying metastatic tumor growth at an early stage has been one of the biggest challenges in the treatment of lung cancer. By genetic lineage tracing approach in a conditional model of Non-Small Cell Lung Cancer (NSCLC) in mice, we demonstrate tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec50c9095c77128d17777b6c9a4cad89
https://hdl.handle.net/21.11116/0000-0003-08E8-F21.11116/0000-0003-08EA-D21.11116/0000-0003-08EB-C
https://hdl.handle.net/21.11116/0000-0003-08E8-F21.11116/0000-0003-08EA-D21.11116/0000-0003-08EB-C
Autor:
Friedrich Grimminger, Baktybek Kojonazarov, Samantha Storn, Werner Seeger, Stefan Gattenlöhner, Ralph T. Schermuly, Rajkumar Savai, Soni Savai Pullamsetti, Andreas Weigert, Ulf R. Rapp, Nefertiti El-Nikhely, Ludger Fink, Gabriele A. Krombach, Henning Gall, Janine Wolf, Hossein Ardeschir Ghofrani, Ylia Salazar
Publikováno v:
Science Translational Medicine. 9
Dyspnea is a frequent, devastating, and poorly understood symptom of advanced lung cancer. In our cohort, among 519 patients who underwent a computed tomography scan for the diagnosis of lung cancer, 250 had a mean pulmonary artery diameter of >28 mm
Autor:
Olga N. Ilinskaya, Johannes Bodner, Andreas Günther, Stephanie Dobersch, Stefan Günther, Indrabahadur Singh, Thomas Braun, Addi J. Romero-Olmedo, Cho-Ming Chao, Rajkumar Savai, Julio Cordero, Guillermo Barreto, Werner Seeger, Gergana Dobreva, Severio Bellusci, Reinhard Dammann, Ulf R. Rapp, Aditi Mehta, Achim Tresch, Stefan Gattenlöhner, Ernesto Guzman-Diaz, Ludger Fink
Publikováno v:
SCOPUS17574676-2016-8-12-SID84998785489
EMBO Molecular Medicine
EMBO Molecular Medicine
Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. Early LC diagnosis is crucial to reduce the high case fatality rate of this disease. In this case-control study, we developed an accurate LC diagnosis test using retrospectivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3df9b3050ab859c9d114120336f8c96
https://openrepository.ru/article?id=721326
https://openrepository.ru/article?id=721326
Autor:
Ernst Wagner, Pjotr Knyazev, Chitra Thakur, Prajakta Oak, Joachim W. Ellwart, Ulf R. Rapp, Axel Ullrich, Andreas Roidl, Florian Kopp
Publikováno v:
International Journal of Cancer. 131:2808-2819
A major obstacle in the successful treatment of cancer is the occurrence of chemoresistance. Cancer cells surviving chemotherapy and giving rise to a recurrence of the tumor are termed cancer stem cells and can be identified by elevated levels of cer
Autor:
Stephan Ludwig, Katharina Köther, Dörthe Masemann, Viktor Wixler, Georg Varga, Brian D. Lichty, Meike Kuhlencord, Ulf R. Rapp, Johannes Roth
Publikováno v:
OncoImmunology, Vol 7, Iss 5 (2018)
Oncoimmunology
Oncoimmunology
Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer and demonstrates high resistance to radiation and chemotherapy. These tumors evade immune system detection by promoting an immunosuppressive tumor microenvironment. Genetic a
Autor:
Christian Hotz, C L R P Yone, Ivaylo Gentschev, Werner Goebel, Joachim Fensterle, Susanne R. Meyer, Simone Spreng, Ulf R. Rapp, Birgit Bergmann
Publikováno v:
Cancer Gene Therapy. 15:85-93
Prostate cancer is the most common malignant tumor in men and is normally associated with increased serum levels of prostate-specific antigen (PSA). Therefore, PSA is one potential target for a prostate cancer vaccine. In this study we analyzed the f
Autor:
Esther Asan, Semra Ceteci, Christiaan Karreman, Fatih Ceteci, Boris W Kramer, Rudolf Götz, Ulf R. Rapp
Publikováno v:
Cancer Cell. 12:145-159
SummaryProgression of non-small-cell lung cancer (NSCLC) to metastasis is poorly understood. Two genetic approaches were used to evaluate the role of adherens junctions in a C-RAF driven mouse model for NSCLC: conditional ablation of the cdh1 gene an
Autor:
Guido Dietrich, Joachim Fensterle, Simon A. Rothen, Andre Collioud, Werner Goebel, Fabian Mollet, Monika Griot-Wenk, Jon Pearman, Simone Spreng, Ulf R. Rapp, Jose A. Ures, Heike Sieber, Ivaylo Gentschev
Publikováno v:
Chemotherapy. 53:177-180
The attenuated Salmonella typhi strain Ty21a is the main constituent of Vivotif®, the only attenuated live oral vaccine against typhoid fever. In comparison with antibiotics, the ‘magic bullets’ which Paul Ehrlich was striving for to treat infec