Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Timothy P. Kuka"'
Autor:
Lewis R. Roberts, Robert Hullsiek, Lindsey A. Lee, Wendy A. Hudson, Barbara R. Tschida, Timothy P. Kuka, Michael A. Linden, Vincent W. Keng, Sandra Wagner, David A. Largaespada, Rachel A. Heuer, Pauline J. Beckmann, Nuri A. Temiz, Khalid Amin, Jesse D. Riordan, Joseph H. Nadeau, Ju Dong Yang, Adam J. Dupuy, Carlos A. Tierrablanca, Aaron L. Sarver
Publikováno v:
Cancer Research. 77:6576-6588
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using Sleeping Beauty
Autor:
David A. Largaespada, Roser Pinyol, Bryant J. Keller, Barbara R. Tschida, Nuri A. Temiz, Helena Cornella, Timothy P. Kuka, Juan E. Abrahante, Michael A. Linden, Nicholas Koes, Khalid Amin, Gabriel Kaufmann, Germán L. Vélez-Reyes, Caitlin B. Conboy, Josep M. Llovet, Hsiangyu Hu, Vincent W. Keng, Clara Alsinet, Timothy K. Starr
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in developm
Autor:
David A. Largaespada, Manel Solé, Kevin A. T. Silverstein, Branden S. Moriarity, Danhua Fan, Timothy P. Kuka, Augusto Villanueva, Jason B. Bell, Aaron L. Sarver, Adam J. Dupuy, Wai L. Lee, Jesse D. Riordan, Barbara R. Tschida, Clara Alsinet, Josep M. Llovet, Daniela Sia, Vincent W. Keng
Hepatocellular carcinoma (HCC) is one of the deadliest solid cancers and is the third leading cause of cancer-related death. There is a universal estimated male/female ratio of 2.5, but the reason for this is not well understood. The Sleeping Beauty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16449023f957a44d7127de5bb72cd1c9
https://europepmc.org/articles/PMC3511635/
https://europepmc.org/articles/PMC3511635/
Autor:
Timothy P. Kuka, Jason B. Bell, Branden S. Moriarity, Vincent W. Keng, David A. Largaespada, Barbara R. Tschida
Publikováno v:
Cancer Research. 74:929-929
The role of zinc finger and BTB domain containing 20 (ZBTB20) in hepatocellular carcinoma (HCC) is not well defined, as there are many discrepancies in the literature regarding its role in liver tumorigenesis. ZBTB20 has been implicated to play a rol
Autor:
David A. Largaespada, Reuben S. Harris, Vincent W. Keng, Timothy P. Kuka, Josep M. Llovet, Sara Toffanin, Hsiangyu Hu, Nuri A. Temiz, Bobbi R. Tschida, Timothy K. Starr, Caitlin B. Conboy, Michael B. Burns
Publikováno v:
Molecular Cancer Therapeutics. 12:A242-A242
Background: R-spondins are secreted agonists of Wnt signaling that function in development and promote tissue stem cell proliferation. Rspo2 was identified as a candidate oncogene in intestinal tumors via a Sleeping Beauty transposon insertional muta