Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Thomas H. Gillingwater"'
Autor:
Bernard L. Schneider, Rashmi Kothary, Maica Llavero-Hurtado, Thomas H. Gillingwater, Abdelmadjid Atrih, Alexandra Tierney, Jean Michaud, Ariane Beauvais, Thomas M. Wishart, Lucia Chehade, Marc-Olivier Deguise, Douglas J. Lamont, Simon H. Parson, Yves De Repentigny, Mary-Ellen Harper, Chantal A. Pileggi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 354-377.e3 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Deguise, M-O, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L, Michaud, J, Llavero hurtado, M, Lamont, D, Atrih, A, Wishart, T, Gillingwater, T, Schneider, B L, Harper, M-E, Parson, S & Kothary, R 2021, ' SMN depleted mice offer a robust and rapid onset model of non-alcoholic fatty liver disease ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.01.019
Cellular and Molecular Gastroenterology and Hepatology
Deguise, M-O, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L, Michaud, J, Llavero hurtado, M, Lamont, D, Atrih, A, Wishart, T, Gillingwater, T, Schneider, B L, Harper, M-E, Parson, S & Kothary, R 2021, ' SMN depleted mice offer a robust and rapid onset model of non-alcoholic fatty liver disease ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.01.019
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and the healthcare systems. Current preclinical models of NAFLD are invariably imperfect and generally take
Autor:
Thomas H. Gillingwater, Helena Chaytow, Yu-Ting Huang, Leire M. Ledahawsky, Anna A L Motyl, Thomas M. Wishart, Samantha L. Eaton, Kiterie M. E. Faller, Douglas J. Lamont, Ewout J N Groen, Rachel A. Kline
Publikováno v:
Human Molecular Genetics
Motyl, A A L, Faller, K, Groen, E J N, Kline, R, Eaton, S, Ledahawsky, L, Chaytow, H, Lamont, D J, Wishart, T, Huang, Y & Gillingwater, T 2020, ' Pre-natal manifestation of systemic developmental abnormalities in spinal muscular atrophy ', Human Molecular Genetics, vol. 29, no. 16, pp. 2674-2683 . https://doi.org/10.1093/hmg/ddaa146
Motyl, A A L, Faller, K, Groen, E J N, Kline, R, Eaton, S, Ledahawsky, L, Chaytow, H, Lamont, D J, Wishart, T, Huang, Y & Gillingwater, T 2020, ' Pre-natal manifestation of systemic developmental abnormalities in spinal muscular atrophy ', Human Molecular Genetics, vol. 29, no. 16, pp. 2674-2683 . https://doi.org/10.1093/hmg/ddaa146
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by mutations in survival motor neuron 1 (SMN1). SMN-restoring therapies have recently emerged; however, preclinical and clinical studies revealed a limited therapeutic time window and sy
Autor:
Thomas H. Gillingwater, Stephen J. Wigmore, Richard J E Skipworth, Janice Miller, Ross A. Jones, Ines Boehm, Thomas M. Wishart
Publikováno v:
The Journal of Clinical Investigation
Boehm, I, Miller, J, Wishart, T M, Wigmore, S J, Skipworth, R J E, Jones, R A & Gillingwater, T H 2020, ' Neuromuscular junctions are stable in patients with cancer cachexia ', Journal of Clinical Investigation, vol. 130, no. 3, pp. 1461-1465 . https://doi.org/10.1172/JCI128411
Boehm, I, Miller, J, Wishart, T M, Wigmore, S J, Skipworth, R J E, Jones, R A & Gillingwater, T H 2020, ' Neuromuscular junctions are stable in patients with cancer cachexia ', Journal of Clinical Investigation, vol. 130, no. 3, pp. 1461-1465 . https://doi.org/10.1172/JCI128411
Cancer cachexia is a major cause of patient morbidity and mortality, with no efficacious treatment or management strategy. Despite cachexia sharing pathophysiological features with a number of neuromuscular wasting conditions, including age-related s
Autor:
Thierry Sulpice, Martin E. Barrios-Llerena, Matthew T G Gibbins, Ruma Banerjee, Thomas H. Gillingwater, Madara Brice, Gillian A. Gray, Huizhong Su, Nicholas M. Morton, Anne Tailleux, Subhankar Singha, Colin Selman, Peter L. Freddolino, Natalie Z.M. Homer, Clare Mc Fadden, Claire McMaster, Marouane Libiad, Kyo Han Ahn, Stephen E. Wilkie, François Briand, Roderick N. Carter, Victor Vitvitsky, Nourdine Faresse, Thierry Le Bihan, Bart Staels, Scott G. Denham, Barry Emerson, Richard C. Hartley, Andrew J. Finch
Publikováno v:
Nicholas Carter, R, Gibbins, M T G, Barrios-Llerena, M E, Wilkie, S E, Freddolino, P L, Libiad, M, Vitvitsky, V, Emerson, B, Le Bihan, T, Brice, M, Su, H, Denham, S G, Homer, N Z M, McFadden, C, Tailleux, A, Faresse, N, Sulpice, T, Briand, F, Gillingwater, T H, Han Ahn, K, Singha, S, McMaster, C, Hartley, R C, Staels, B, Gray, G A, J Finch, A, Selman, C, Banerjee, R & Morton, N M 2021, ' The Hepatic Compensatory Response to Elevated Systemic Sulfide Promotes Diabetes ', Cell Reports . https://doi.org/10.1016/j.celrep.2021.109958
Cell Reports
Cell Reports
Summary Impaired hepatic glucose and lipid metabolism are hallmarks of type 2 diabetes. Increased sulfide production or sulfide donor compounds may beneficially regulate hepatic metabolism. Disposal of sulfide through the sulfide oxidation pathway (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc399f070262aaf17b48ed0cb1b2591
https://www.pure.ed.ac.uk/ws/files/239134274/CELL_REPORTS_D_21_00011_R3.pdf
https://www.pure.ed.ac.uk/ws/files/239134274/CELL_REPORTS_D_21_00011_R3.pdf
Publikováno v:
Chaytow, H, Faller, K, Huang, Y & Gillingwater, T H 2021, ' Spinal muscular atrophy : From approved therapies to future therapeutic targets for personalized medicine ', Cell Reports Medicine, vol. 2, no. 7, 100346 . https://doi.org/10.1016/j.xcrm.2021.100346
Cell Reports Medicine
Cell Reports Medicine
Summary Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease that, in the most severe cases and when left untreated, leads to death within the first two years of life. Recent therapeutic advances have given hope to families a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fcb38127d921ce7ead22476f2208ca
https://www.pure.ed.ac.uk/ws/files/214578892/ChaytowEtAl_CellRepMed_9Jun2021_shorter_bibliography_v2.pdf
https://www.pure.ed.ac.uk/ws/files/214578892/ChaytowEtAl_CellRepMed_9Jun2021_shorter_bibliography_v2.pdf
Publikováno v:
The FASEB Journal. 35
Publikováno v:
James, R, Chaytow, H, Ledahawsky, L & Gillingwater, T H 2021, ' Revisiting the role of mitochondria in spinal muscular atrophy ', Cellular and Molecular Life Sciences, vol. 78, pp. 4785-4804 . https://doi.org/10.1007/s00018-021-03819-5
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences
Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease of variable clinical severity that is caused by mutations in the survival motor neuron 1 (SMN1) gene. Despite its name, SMN is a ubiquitous protein that functions within and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b946fe93d3fa870baa2884b8e90cb9e
https://www.pure.ed.ac.uk/ws/files/239827185/Rachel_James_CMLS_review.pdf
https://www.pure.ed.ac.uk/ws/files/239827185/Rachel_James_CMLS_review.pdf
Autor:
R. Yanez-Munoz, Thomas H. Gillingwater, H. Shorrock, Heidi R. Fuller, B. Schneider, S. Synowsky, D. Soltic, S. Shirran, E. Crompton, Melissa Bowerman, S. Owen
Publikováno v:
Neuromuscular Disorders. 31:S131-S132
Autor:
Thomas Becker, Thomas H. Gillingwater, Helena Chaytow, Catherina G. Becker, Neil O. Carragher, Hannah L. Smith, Ana-Maria Oprişoreanu, Sophia Krix
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Oprişoreanu, A, Smith, H L, Krix, S, Chaytow, H, Carragher, N O, Gillingwater, T H, Becker, C G & Becker, T 2021, ' Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy ', Disease Models and Mechanisms, vol. 14, no. 4 . https://doi.org/10.1242/dmm.047761
article-version (VoR) Version of Record
Oprişoreanu, A, Smith, H L, Krix, S, Chaytow, H, Carragher, N O, Gillingwater, T H, Becker, C G & Becker, T 2021, ' Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy ', Disease Models and Mechanisms, vol. 14, no. 4 . https://doi.org/10.1242/dmm.047761
Synapses are particularly vulnerable in many neurodegenerative diseases and often the first to degenerate, for example in the motor neuron disease spinal muscular atrophy (SMA). Compounds that can counteract synaptic destabilisation are rare. Here, w
Autor:
Niko Hensel, Peter Claus, Elena Hernandez-Gerez, Fabio Quondamatteo, Kiterie M. E. Faller, Yu-Ting Huang, Daniela Kuhn, Simon H. Parson, Hazel Allardyce, Thomas H. Gillingwater
Publikováno v:
Human molecular genetics. 29(14)
Spinal muscular atrophy (SMA) occurs as a result of cell-ubiquitous depletion of the essential survival motor neuron (SMN) protein. Characteristic disease pathology is driven by a particular vulnerability of the ventral motor neurons of the spinal co