Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Stephen R. Bloom"'
Autor:
Victoria Salem, Lysia Demetriou, Kleopatra Alexiadou, Tricia Tan, Alexander D. Miras, Waljit S. Dhillo, Preeshila Behary, Matthew B. Wall, Ahmed R. Ahmed, Sanjay Purkayastha, Stephen R. Bloom, George Tharakan, Samantha Scholtz
Publikováno v:
Diabetes Care
OBJECTIVE Weight loss achieved with very-low-calorie diets (VLCDs) can produce remission of type 2 diabetes (T2D), but weight regain very often occurs with reintroduction of higher calorie intakes. In contrast, bariatric surgery produces clinically s
Autor:
Wanling Song, Alejandra Tomas, Ben Jones, Tricia Tan, T. B. Ansell, Mark S.P. Sansom, Emma Rose McGlone, David Carling, Stephen R. Bloom, C. Dunsterville
Publikováno v:
Molecular metabolism. 63
Objective To determine whether glucagon receptor (GCGR) actions are modulated by cellular cholesterol levels. Methods We determined the effects of experimental cholesterol depletion and loading on glucagon-mediated cAMP production, ligand internalisa
Autor:
Kerstin Stemmer, Stephen C. Woods, Harvey J. Grill, Jens J. Holst, Alessandro Pocai, Michael A. Nauck, Andreas Fritsche, Richard D. DiMarchi, David A. D'Alessio, Mads Tang-Christensen, Diego Perez-Tilve, Darleen A. Sandoval, Randy J. Seeley, Wolfgang Langhans, Daniel J. Drucker, Stephen R. Bloom, M.H. Tschöp, Brian Finan, Fiona M. Gribble, Timo D. Müller, Peter R. Flatt, Joel F. Habener, Juris J. Meier, Thue W. Schwartz, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 30, Iss, Pp 72-130 (2019)
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, in
Autor:
Charlotte E Hinds, Tricia Tan, Philip Pickford, Bryn M. Owen, David Hope, James Minnion, Stephen R. Bloom, Ben Jones
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Glucagon receptor agonists show promise as components of next generation metabolic syndrome pharmacotherapies. However, the biology of glucagon action is complex, controversial, and likely context dependent. As such, a better understanding of chronic
Autor:
Jia V. Li, James Minnion, Kleopatra Alexiadou, George Tharakan, Ahmed R. Ahmed, Stephen R. Bloom, Matthew R. Lewis, Preeshila Behary, Sanjay Purkayastha, Ben Jones, Tricia Tan, Caroline Sands
Publikováno v:
e782
e767
The Journal of Clinical Endocrinology and Metabolism
e767
The Journal of Clinical Endocrinology and Metabolism
Context The gut-derived peptide hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY) are regulators of energy intake and glucose homeostasis and are thought to contribute to the glucose-lowering effects of bariatric sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79846c6772014111d5d75a84f56ac136
http://hdl.handle.net/10044/1/91275
http://hdl.handle.net/10044/1/91275
Publikováno v:
Expert Opinion on Drug Discovery. 14:1151-1159
Introduction: Obesity is a global pandemic and new pharmacotherapies which combine weight loss efficacy, long-term safety, and reversal of metabolic co-morbidities are sorely needed. Gut hormones p...
Autor:
Madhawi Aldhwayan, Stephen R. Bloom, Werd Al-Najim, Belén Pérez-Pevida, Aviva Petrie, Omar A. Khan, Ahmed R. Ahmed, Veronica Greener, Barbara McGowan, Alexander D. Miras, Harvinder Chahal, Samantha Scholtz, Tricia Tan, Anna Kamocka, Emma Rose McGlone, Rachel L. Batterham
Publikováno v:
The Lancet Diabetes & Endocrinology. 7:549-559
Summary Background Many patients with type 2 diabetes do not achieve sustained diabetes remission after metabolic (bariatric) surgery for the treatment of obesity. Liraglutide, a glucagon-like peptide-1 analogue, improves glycaemic control and reduce
Autor:
Ahmed R. Ahmed, Julia Kenkre, Tricia Tan, Sanjay Purkayastha, Stephen R. Bloom, A Toby Prevost, Khalefah Malallah, Alexandra I. F. Blakemore
Publikováno v:
BMJ Open
BMJ Open, Vol 11, Iss 2 (2021)
BMJ Open, Vol 11, Iss 2 (2021)
IntroductionType 2 diabetes mellitus (T2DM) and obesity are pandemic diseases that lead to a great deal of morbidity and mortality. The most effective treatment for obesity and T2DM is bariatric or metabolic surgery; it can lead to long-term diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abc9d30f398fec849d01c62865da08d
http://hdl.handle.net/10044/1/87213
http://hdl.handle.net/10044/1/87213
Autor:
Sanjay Purkayastha, Victoria Salem, Stephen R. Bloom, Alexander D. Miras, Tricia Tan, Saira Hameed, Ahmed R. Ahmed, Karim Meeran, Haya Alessimii, Samantha Scholtz, Owais Dar, Harvinder Chahal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8989e646bde02d613682e216074b798e
https://doi.org/10.1111/dom.14207/v3/response1
https://doi.org/10.1111/dom.14207/v3/response1
Autor:
Victoria Salem, Alexander D. Miras, Stephen R. Bloom, Ahmed R. Ahmed, Tricia Tan, Harvinder Chahal, Saira Hameed, Haya Alessimii, Karim Meeran, Samantha Scholtz, Sanjay Purkayastha, Owais Dar
Publikováno v:
Diabetes, obesitymetabolismREFERENCES. 23(1)
‘Imperial Satiety Protocol’ (I-SatPro) is a new multifaceted approach to weight loss for people with obesity (PwO), encompassing dietary advice, time-restricted eating, physical activity and coaching to support behaviour change. Participants (n =