Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sandra Duquesne"'
Autor:
Heide Dierbach, Justin Mastroianni, Annette Schmitt-Graeff, Martina Falk, Natalie Stickel, Dietmar Pfeifer, Melanie Boerries, Kathrin Hanke, Wolfgang Melchinger, Sandra Duquesne, Dominik Schmidt, Frank Meiss, Hana Andrlová, Geoffroy Andrieux, Robert Zeiser
Publikováno v:
Cancer Research. 79:183-195
MicroRNAs (miR) are small noncoding RNAs that regulate gene expression, posttranscription, and manipulate immune responses in different types of cancers. In this study, we identify miR-146a as a negative regulator of immune activation, comparable to
Autor:
Franziska M. Uhl, Dietmar Pfeifer, Melanie Boerries, Donatella De Feo, Shaima’a Hamarsheh, Heiko Becker, Benedikt S. Saller, Lena Osswald, Claudia Lengerke, Janaki Manoja Vinnakota, Miriam Erlacher, Geoffroy Andrieux, Justus Duyster, Sandra Duquesne, Robert Zeiser, Martina Konantz, Mark E. Cooper, Annette Schmitt-Graeff, Tilman Brummer, Christoph Schürch, Charlotte M. Niemeyer, Nils Venhoff, Olaf Groß, Michael Lübbert, Khalid Shoumariyeh, Burkhard Becher, Susanne Unger, Bruce R. Blazar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Sebastian Halbach, Marina Kreutz, Joy Edwards-Hicks, Melanie Boerries, Justus Duyster, Jörg Büscher, Tobias Madl, Olaf Groß, Sandra Duquesne, David O’Sullivan, Eileen Haring, Wolfgang Melchinger, Gesa Richter, Petya Apostolova, Tilman Brummer, Michael Lübbert, Erika L. Pearce, Franziska M. Uhl, Barbara Sauer, Sophia Chen, Bruce R. Blazar, Geoffroy Andrieux, Robert Zeiser, Annette Schmitt-Graeff, Khalid Shoumariyeh
Publikováno v:
Sci Transl Med
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after allo-HCT exhibited reduced glycolysis and interferon-γ production.
Autor:
Justyna Rawluk, Frank Meiss, Melanie Boerries, Annette Schmitt-Graeff, Federico Simonetta, Robert S. Negrin, Severin Dicks, Justus Duyster, David Rafei-Shamsabadi, Robert Zeiser, Martina Falk, Natalie Köhler, Konrad Aumann, Sandra Duquesne, Nora Rebeka Javorniczky, Patrick Marschner, Manching Ku, Kathrin Hanke-Müller, Dominik Marschner, Eileen Haring
Publikováno v:
JCI Insight, Vol. 5, No 6 (2020) P. 1317
JCI Insight
JCI Insight
Immune checkpoint inhibitor (ICI) therapy has shown a significant benefit in the treatment of a variety of cancer entities. However, immune-related adverse events (irAEs) occur frequently and can lead to ICI treatment termination. MicroRNA-146a (miR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddb817444cfc4cfd247a46fdf52174d
https://archive-ouverte.unige.ch/unige:156449
https://archive-ouverte.unige.ch/unige:156449
Autor:
Zhan Gao, Jan Hülsdünker, Katja J. Ottmüller, Sandra Duquesne, Geoffrey R. Hill, Oliver S. Thomas, Hannes P. Neeff, Brian T. Fife, Marie Follo, Robert Zeiser, Heide Dierbach, Bruce R. Blazar, Georg Häcker, Gabriele Prinz, Motoko Koyama, Andreas Beilhack, Ali Al-Ahmad, Tim Lämmermann, Susanne Kirschnek, Martin J. Blaser
Publikováno v:
Blood
Conditioning-induced damage of the intestinal tract plays a critical role during the onset of acute graft-versus-host disease (GVHD). Therapeutic interference with these early events of GVHD is difficult, and currently used immunosuppressive drugs ma
Autor:
Eileen Haring, Ozlem Oyardi, Sandra Duquesne, Burkhard Becher, Gerald B. Pier, Jan Hülsdünker, Georg Häcker, Oliver Pabst, Robert Zeiser, Sonia Tugues, Colette Cywes-Bentley, Oliver S. Thomas, Nicolás Gonzalo Núñez, Schmitt-Graeff, Susanne Unger, Christian Koenecke, Martin J. Blaser, Justus Duyster, Susanne Kirschnek, Zhan Ghao, Petya Apostolova
Publikováno v:
Blood. 134:3209-3209
Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy for different malignant and non-malignant hematologic diseases. Major life-threatening complications after allo-HCT are acute graft-versus-host disease (aGVHD) and severe
Autor:
Donald Bunjes, Sebastian Halbach, Dietmar Pfeifer, Philipp Hemmati, Robert S. Negrin, Fabio Ciceri, Jean-Yves Cahn, Markus Ditschkowski, Pavan Reddy, Kathrin Hanke, Daniela Dörfel, Susan Klaeger, Jürgen Finke, Zehan Hu, Gabriele Ihorst, Gérard Socié, Sanaz Taromi, Andreas Hochhaus, Glen A Kennedy, Omid Shah, Andreas Neubauer, Robert Thimme, Michael Schultheiss, Sabine Spath, Dietrich W. Beelen, Sandra Duquesne, Arnim Weber, Geoffrey R. Hill, Ronjon Chakraverty, Jürgen Kuball, Guido Kobbe, Nikolas von Bubnoff, Andrea S. Henden, Betul Oran, Burkhard Becher, Bernhard Kuster, Christoph Rummelt, Lena Osswald, Hartmut Bertz, Wolfgang Bethge, Eva-Maria Wagner, Arnon Nagler, Eliana Ruggiero, Saar Gill, Miguel Waterhouse, Andreas Mackensen, Dominik Bettinger, Francis Baumgartner, Florian Kuchenbauer, Anita Sarma, Takanori Teshima, Erika L. Pearce, Antonia M.S. Müller, Kathleen Stabla, John M. Magenau, Evelyn Ullrich, Nicolaus Kröger, Georg Häcker, Simone Thomas, Myriam Labopin, Ghulam J. Mufti, Jan E. Ehlert, Lutz P. Müller, Marie Follo, Dominik Wolf, Tony Andreas Müller, Michael Lübbert, Jacqueline Schnell, Christof Scheid, Takeshi Kondo, Donal P. McLornan, Thomas Pabst, Konrad Wilhelm, Chiara Bonini, Wolf Rösler, Simon Richardson, Cordula A. Jilg, Andrea Schmidts, Luca Vago, Joseph H. Antin, Annette Schmitt-Graeff, Yakup Tanriver, Michael A. Caligiuri, Wolfgang Herr, Kai-Li Yan, Lukas Braun, Daniel J. Weisdorf, Katayoun Rezvani, Giang Lam Vuong, Tilman Brummer, Stephan Meckel, Ralph Wäsch, Geoffroy Andrieux, Soroush Doostkam, Hauke Busch, Dennis Dong Hwan Kim, Sabine Gerull, Bruce R. Blazar, Robert Zeiser, Merav Bar, Flore Sicre-de-Fontbrune, Daniel Feger, Melanie Börries, Wolfgang Melchinger, Petya Apostolova, C. Leiber, Udo Holtick, Walter J.F.M. van der Velden, Renate Arnold, Rainer Claus, Justus Duyster, Nimitha R. Mathew, David O’Sullivan, Alexandros Spyridonidis, S K Metzelder, Thomas Schroeder, Jörg Halter, Johanna Haag, Friedrich Stölzel, Christoph Schmid, Anna Lena Illert, Claudia Lengerke, Björn Hackanson, Joern Dengjel, Francis Ayuk, Rainer Ordemann, Sonia Tugues, Marco Prinz, Inken Hilgendorf, Andreas Burchert
Publikováno v:
Nature Medicine
Nature Medicine, 24, 282-291
Nature Medicine, 24, 3, pp. 282-291
Nature Medicine, 24, 282-291
Nature Medicine, 24, 3, pp. 282-291
Contains fulltext : 190745.pdf (Publisher’s version ) (Closed access) Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogenei