Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Richard A, Koup"'
Autor:
Cynthia L Gay, Katherine S James, Marina Tuyishime, Shane D Falcinelli, Sarah B Joseph, Matthew J Moeser, Brigitte Allard, Jennifer L Kirchherr, Matthew Clohosey, Samuel L M Raines, David C Montefiori, Xiaoying Shen, Robert J Gorelick, Lucio Gama, Adrian B McDermott, Richard A Koup, John R Mascola, Michelle Floris-Moore, JoAnn D Kuruc, Guido Ferrari, Joseph J Eron, Nancie M Archin, David M Margolis
Publikováno v:
J Infect Dis
We tested the combination of a broadly neutralizing HIV antibody with the latency reversal agent vorinostat (VOR). Eight participants received 2 month-long cycles of VRC07-523LS with VOR. Low-level viremia, resting CD4+ T-cell–associated HIV RNA (r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6faf11d8516c4ae68e516f570f2bdba2
https://europepmc.org/articles/PMC8889279/
https://europepmc.org/articles/PMC8889279/
Autor:
Amarendra Pegu, Giulia Fabozzi, Joana Dias, John R. Mascola, Wanwisa Promsote, Cassandra G. Almasri, Richard A. Koup, Lucio Gama, Constantinos Petrovas, John Paul Todd, Jonathan Fintzi, Yoshiaki Nishimura, Mangaiarkarasi Asokan, Kylie March, Malcolm A. Martin, Jeffrey D. Lifson
Publikováno v:
J Clin Invest
Primary HIV-1 infection can be classified into six Fiebig stages based on virological and serological laboratory testing, whereas simian-HIV (SHIV) infection in nonhuman primates (NHPs) is defined in time post-infection, making it difficult to extrap
Autor:
Jason Hataye, Zhi Yong Yang, Nicole A. Doria-Rose, John R. Mascola, Giulia Fabozzi, Hui Li, Tongqing Zhou, Wei Shi, Kylie March, Brandon F. Keele, George M. Shaw, Joseph P. Casazza, Kathryn E. Foulds, Joana Dias, Wanwisa Promsote, Gary J. Nabel, Michelle D. Cully, Richard A. Koup, Xuejun Chen, Amarendra Pegu, Ling Xu, Ronnie Wei, Hui Geng, Cuiping Liu, Amy Noe, Jeffrey D. Lifson, Cassandra G. Almasri, Ercole Rao, Constantinos Petrovas, Mangaiarkarasi Asokan, John-Paul Todd, Krisha McKee, Christine M. Fennessey, Stephen D. Schmidt, Eun Sung Yang, Megan E. DeMouth, Keyun Wang, Shing-Fen Kao
Publikováno v:
SSRN Electronic Journal.
Broadly neutralizing antibodies (bNAbs) represent an alternative to drug therapy for the treatment of HIV-1 infection. Immunotherapy with single bNAbs often leads to emergence of escape variants, suggesting a potential benefit of combination bNAb the
Autor:
Richard A. Koup, Michel C. Nussenzweig, Yoshiaki Nishimura, Reza Sadjadpour, Sara Ferrando-Martinez, Malcolm A. Martin, Romas Geleziunas, Alicia Buckler-White, Rajeev Gautam, Olivia K. Donau, Eric Jesteadt, Joana Dias
Publikováno v:
The Journal of Experimental Medicine
Macaque recipients of anti–HIV-1 combination NAb treatment starting on PI day 3 or week 2 generate CD8+ cellular immunity that maintains durable suppression of SHIV replication and circulating CD4+ T cell levels during a 3–6-yr observation period
Autor:
Richard A. Koup, Christine S. Hopp, Ababacar Diouf, Peter D. Crompton, Shanping Li, Christopher M. Tipton, Michael Chambers, Safiatou Doumbo, Sarah F. Andrews, Jeff Skinner, Boubacar Traore, Kristin L. Boswell, Padmapriya Sekar, Kazutoyo Miura, Eric O. Long, Aissata Ongoiba, Joshua Tan, Kassoum Kayentao, Silvia Portugal, Adrian B. McDermott, Carole A. Long
IgG antibodies are known to play a central role in naturally acquired immunity to blood-stage malaria in humans, but little is known about the IgM response to blood-stage malaria, the mechanisms by which IgM may protect, or the underlying biology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e854c0731aa902a94fec3fbd765fadd
https://doi.org/10.1101/2020.04.12.030049
https://doi.org/10.1101/2020.04.12.030049
Autor:
Pablo Tebas, Robert F. Siliciano, Mohamed Abdel-Mohsen, Jun Lai, E. Turner Overton, Kevin McCormick, James A. Hoxie, Randall Tressler, Scott Sherrill-Mix, Janet M. Siliciano, Jonathan Z. Li, D. Brenda Salantes, Richard A. Koup, Tuhina Srivastava, Yu Zheng, Felicity Mampe, Gerald H. Learn, Frederic D. Bushman, Subul A. Beg, Katharine J. Bar
Publikováno v:
Journal of Clinical Investigation. 128:3102-3115
BACKGROUND. The effect of a brief analytical treatment interruption (ATI) on the HIV-1 latent reservoir of individuals who initiate antiretroviral therapy (ART) during chronic infection is unknown. METHODS. We evaluated the impact of transient viremi
Autor:
John W. Mellors, Julie E. Ledgerwood, Richard A. Koup, Christine M. Durand, Michael C. Keefer, Susan L. Koletar, Lu Zheng, Justin Ritz, Joshua C. Cyktor, Bernard J.C. Macatangay, Robert T. Bailer, Joseph J. Eron, Sharon A. Riddler
Publikováno v:
Open Forum Infectious Diseases
BackgroundBroadly neutralizing monoclonal antibodies (bnMAbs) may promote clearance of HIV-1-expressing cells through antibody-dependent cell-mediated cytotoxicity. We evaluated the effect of the CD4-binding site bnMAb, VRC01, on measures of HIV-1 pe
Autor:
Jeffrey D. Lifson, John R. Mascola, Sean P. O’Brien, Theodora Hatziioannou, Paul D. Bieniasz, Jason Gorman, Brandon F. Keele, George M. Shaw, Gregory Q. Del Prete, Richard A. Koup, Taina T. Immonen, Adrienne E. Swanstrom, Christine M. Fennessey, Amarendra Pegu, Kathryn E. Foulds, Nicole A. Doria-Rose, Peter D. Kwong, Sung-Youl Ko, Mario Roederer, Carolyn Williamson, Stephen D. Schmidt, Hui Li
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore,
Autor:
Eirini Moysi, Timothy W. Schacker, Krystelle Nganou Makamdop, Jodi Anderson, Gregory J. Beilman, Jeffrey G. Chipman, Peter Mugyenyi, Cavan S. Reilly, Ted M. Ross, Jared Schuster, Ray Lanciotti, Daniel C. Douek, Torfi Hoskuldsson, Rafick Pierre Sekaly, Maria T. Arévalo, Patrick Ssengendo, Lydie Trautmann, Meghan K Rothenberger, Jordan Schoephoerster, Bartosz Grzywacz, Rama Akondy, Lin Zhang, Richard A. Koup, Samuel P. Callisto, Constantinos Petrovas, Cissy Kityo, Michael M. Lederman, Benigno Rodriguez, Thomas E. Schmidt, Francis Ssali, Thomas Reimann, Rafi Ahmed, Proscovia Muloma
Publikováno v:
Journal of clinical investigation, 128(7), 2763-2773. The American Society for Clinical Investigation
There is marked variability in vaccine efficacy among global populations. In particular, individuals in low- to middle-income countries have been shown to be less responsive to vaccines than those from developed nations. Several factors, including en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79d289bb353b80dc6906f101e312e59
https://pure.amc.nl/en/publications/lymphoid-tissue-fibrosis-is-associated-with-impaired-vaccine-responses(71efe01b-7c23-43d5-acdc-0a10c53ef7ef).html
https://pure.amc.nl/en/publications/lymphoid-tissue-fibrosis-is-associated-with-impaired-vaccine-responses(71efe01b-7c23-43d5-acdc-0a10c53ef7ef).html
Autor:
David Price, Alberto Sada Japp, Sara Ferrando-Martinez, Leticia Kuri-Cervantes, Marcus Buggert, Michael R. Betts, Amaranta Rivero-Arrieta, Heidi M. Gunzelman, Son Nguyen, Gustavo Reyes-Terán, Emma Gostick, Ali Naji, Richard A. Koup, Yuria Ablanedo-Terrazas, Perla M. Del Rio Estrada, David H. Canaday, Morgan A. Reuter, Constantinos Petrovas
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3458-3470 (2017)
Summary: Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8+ T cells play a critical role in control of HIV, but their functional attributes in lymph nodes (LNs) remain unclear. Here, we show that memory,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fa1c9816b70757cbb205aa882f7e13