Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Pankaj Vats"'
Autor:
Namita G. Hattangady, Pankaj Vats, Thomas J. Giordano, Juilee Rege, Scott A. Tomlins, Kazutaka Nanba, Amy R Blinder, Chia Jen Liu, William E. Rainey, Tobias Else, Chandan Kumar-Sinha
Publikováno v:
Hypertension. 75:645-649
Driver somatic mutations for aldosterone excess have been found in ≈90% of aldosterone-producing adenomas (APAs) using an aldosterone synthase (CYP11B2)-guided sequencing approach. In the present study, we identified a novel somatic CACNA1H mutatio
Publikováno v:
Indian Journal of Medical Sciences. 71:28-34
Objectives: The aim of this study was to study patient, disease, and treatment related characteristics in geriatric patients 65 years and older treated by Radiotherapy (RT). Material and methods: A retrospective observational and descriptive study wa
Autor:
Xiaoming Wang, Yuping Zhang, Arul M. Chinnaiyan, Xuhong Cao, Gregory Raskind, Thomas J. Giordano, Noshad Hosseini, Pankaj Vats, Saravana M. Dhanasekaran, Fengyun Su, Todd M. Morgan, Marcin Cieslik, Rahul Mannan, Sethuramasundaram Pitchiaya, Rohit Mehra, Ajjai Alva, Stephanie J. Ellison, Sathiya Pandi Narayanan, Chandan Kumar-Sinha
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Renal cell carcinomas (RCCs) are heterogeneous malignancies thought to arise from kidney tubular epithelial cells, and clear cell RCC is the most common entity. This study demonstrates that cell atlases generated from benign kidney and t
Autor:
Jeffrey K. Ng, Pankaj Vats, Elyn Fritz-Waters, Stephanie Sarkar, Eleanor I. Sams, Evin M. Padhi, Zachary L. Payne, Shawn Leonard, Marc A. West, Chandler Prince, Lee Trani, Marshall Jansen, George Vacek, Mehrzad Samadi, Timothy T. Harkins, Craig Pohl, Tychele N. Turner
Detection of de novo variants (DNVs) is critical for studies of disease-related variation and mutation rates. We developed a GPU-based workflow to rapidly call DNVs (HAT) and demonstrated its effectiveness by applying it to 4,216 Simons Simplex Colle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16ce4003b1ce3f9fe134c3f9cc67934c
https://doi.org/10.1101/2021.05.27.445979
https://doi.org/10.1101/2021.05.27.445979
Autor:
Kathryn McFadden, Arul M. Chinnaiyan, Andrew H. Zureick, Bailey Anderson, Sriram Venneti, Lili Zhao, Robert J. Lonigro, Karin M. Muraszko, Bernard L. Marini, Brendan Mullan, Patricia L. Robertson, Xuhong Cao, Pankaj Vats, Marcin Cieslik, Rajen Mody, Carl Koschmann, Jessica Everett, Paul E. McKeever, Sandra Camelo-Piragua, Yi-Mi Wu, Marcia Leonard, Hugh J. L. Garton, Cormac O. Maher, Andrew P. Lieberman, Katayoon Kasaian, Kevin Frank, John R. Prensner, Dan R. Robinson, Chandan Kumar-Sinha
Publikováno v:
JCO Precis Oncol
Purpose Brain tumors have become the leading cause of cancer-related mortality in young patients. Novel effective therapies on the basis of the unique biology of each tumor are urgently needed. The goal of this study was to evaluate the feasibility,
Autor:
Nicole D. Lee, Pankaj Vats, Saravana M. Dhanasekaran, Fengyun Su, Rohit Mehra, Arul M. Chinnaiyan, Robert J. Lonigro, Kumpati Premkumar, Jesse K. McKenney, Kiril Trpkov, Xuhong Cao
Publikováno v:
European Urology. 74:483-486
Renal cell carcinomas (RCC) with overlapping histomorphologic features poses diagnostic challenges. This is exemplified in RCCs with eosinophilic cytoplasm that include eosinophilic solid and cystic RCC (ESC RCC), RCCs in germline aberrations of tube
Autor:
David Smith, Moshe Talpaz, Megan E.V. Caram, Scott M. Schuetze, Mark M. Zalupski, Daniel F. Hayes, Erin F. Cobain, Chandan Kumar-Sinha, Robert J. Lonigro, Arul M. Chinnaiyan, Anne F. Schott, Erica Rabban, Elena M. Stoffel, Rashmi Chugh, Yi-Mi Wu, Vaibhav Sahai, Dan R. Robinson, Yu Ning, Michelle F. Jacobs, Ajjai Alva, Aaron M. Udager, Sandra Camelo-Piragua, Xuhong Cao, Pankaj Vats, Lakshmi P. Kunju, Francis P. Worden, Rui Wang, Marcin Cieslik, David R. Lucas, Janice Bell
Publikováno v:
JAMA Oncology
Key Points Question What is the clinical utility of genomic profiling for patients with advanced solid tumors? Findings In this cohort study of 1015 patients who underwent integrative genomic profiling, a high rate of pathogenic germline variants and
Autor:
Shuang Cai, Elizabeth R. Duffy, Felipe da Veiga Leprevost, D. R. Mani, Antonio Colaprico, Jiayi Ji, Mehdi Mesri, Alicia Francis, Peter B. McGarvey, Myvizhi Esai Selvan, Corbin D. Jones, Michael J. Birrer, Robert J. Welsh, Lori Bernard, Shankha Satpathy, Li Ding, Sara R. Savage, Eugene S. Fedorov, Fernanda Martins Rodrigues, Marcin J. Domagalski, Jennifer M. Eschbacher, Shayan C. Avanessian, Boris Reva, Harsh Batra, Suhas Vasaikar, Nathan Edwards, Michael A. Gillette, Chet Birger, Scott D. Jewell, Kei Suzuki, William Bocik, Shilpi Singh, Meenakshi Anurag, Karen E. Christianson, Namrata D. Udeshi, Vasileios Stathias, Warren G. Tourtellotte, Karl R. Clauser, Shutack, Andrii Karnuta, Dana R. Valley, Kelly V. Ruggles, Qing Kay Li, Amanda G. Paulovich, MacIntosh Cornwell, Shankara Anand, Bartosz Kubisa, Pierre M. Jean Beltran, James Suh, Gilbert S. Omenn, Azra Krek, Wohaib Hasan, Yongchao Dou, David Fenyö, Henry Rodriguez, Samuel H. Payne, Małgorzata Wojtyś, Daniel W. Chan, Bo Wen, Nicollette Maunganidze, Özgün Babur, Renganayaki Pandurengan, Karen A. Ketchum, Nikolay Gabrovski, Pankaj Vats, Saravana M. Dhanasekaran, Richard D. Smith, Gad Getz, Sailaja Mareedu, Yuxing Liao, Mikhail Krotevich, Hui Zhang, Eric J. Jaehnig, Charles A. Goldthwaite, Alexey I. Nesvizhskii, Katherine A. Hoadley, Alexander A. Green, Francesca Petralia, Chandan Kumar-Sinha, Karsten Krug, Eunkyung An, Elena V. Ponomareva, Ximing Tang, Nancy Roche, Daniel C. Rohrer, David I. Heiman, Arul M. Chinnaiyan, Pamela Grady, Rebecca I. Montgomery, Galen Hostetter, Liqun Qi, Stephan C. Schürer, George D. Wilson, Pushpa Hariharan, Zhen Zhang, Yvonne, David Chesla, Chia-Kuei Mo, Maria Gabriela Raso, Negin Vatanian, Paul K. Paik, Fei Ding, Thomas L. Bauer, Barbara Hindenach, Matthew J. Ellis, Chen Huang, Karin D. Rodland, Oluwole Fadare, Ramaswamy Govindan, Eric E. Schadt, Sandra Cottingham, Barbara Pruetz, Sendurai A. Mani, Shirley Tsang, Carissa Huynh, Weiping Ma, Jennifer E. Maas, Tobias Schraink, Stacey Gabriel, Bing Zhang, Tara Hiltke, Rama Soundararajan, Tatiana Omelchenko, Brian J. Druker, Matthew A. Wyczalkowski, Neil R. Mucci, Ziad Hanhan, Donna E. Hansel, Yifat Geffen, Mathangi Thiagarajan, Xiaojun Jing, Pei Wang, Alfredo Molinolo, Tanmayi Vashist, Ratna R. Thangudu, Maciej Wiznerowicz, Edwin R. Parra, Tanvi H. Visal, Maureen Dyer, Melissa Borucki, Ki Sung Um, Jonathan T. Lei, Marcin Cieslik, Christopher R. Kinsinger, M. Harry Kane, Houxiang Zhu, Chelsea J. Newton, Steven A. Carr, Tao Liu, Wenke Liu, Volodymyr Sovenko, Olga Potapova, Eric J. Burks, Song Cao, Ana I. Robles, Yuping Zhang, Yize Li, Midie Xu, Erik J. Bergstrom, Zeynep H. Gümüş, Kai Li, Xiaoyu Song
Publikováno v:
Cell
Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a deeper exposition of LSCC biology with potential therapeutic implications. We
Autor:
Daniel L. Hertz, Erika Mora, Pankaj Vats, Bailey Anderson, Yi-Mi Wu, Rajen Mody, Kevin Frank, Andrew Glatz, Amy L. Pasternak, Dan R. Robinson, Robert J. Lonigro, Arul M. Chinnaiyan, Erica Rabban
Publikováno v:
JCO Precis Oncol
Purpose Evidence-based guidelines inform treatment decisions for patients for whom germline genetic information is available. Our real-time tumor sequencing program, which makes precision treatment decisions for patients with cancer, produces matched
Autor:
Ronald F. Siebenaler, Jean Ching-Yi Tien, Vijaya L. Dommeti, Rahul Mannan, Stephanie J. Ellison, Sethuramasundaram Pitchiaya, Xuhong Cao, Seema Chugh, Howard C. Crawford, Ingrid J. Apel, Jessica Waninger, Chandan Kumar-Sinha, Andrew Goodrum, Sanjana Eyunni, Sylvia Zelenka-Wang, Pankaj Vats, Yuping Zhang, Malay Mody, Jiaqi Shi, Xiaoming Wang, Alice Xu, Sunita Shankar, John J.G. Tesmer, Arul M. Chinnaiyan
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Both KRAS and EGFR are essential mediators of pancreatic cancer development and interact with Argonaute 2 (AGO2) to perturb its function. Here, in a mouse model of mutant KRAS-driven pancreatic cancer, loss of AGO2 allows precursor lesion (PanIN) for