Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lucia Knopfová"'
Autor:
Tereza Kučírková, Hana Lejdarova, Veronika Oralova, Eva Matalová, Serhiy Forostyak, Petr Kuglík, Zdenek Koristek, Veronika Pospisilova, Ladislava Vymetalova, Eva Makaturova, Lucia Knopfová, Tomas Kasko, Petr Beneš
Publikováno v:
Neurochemical Research. 45:204-214
Neurodegenerative disorders present a broad group of neurological diseases and remain one of the greatest challenges and burdens to mankind. Maladies like amyotrophic lateral sclerosis, Alzheimer's disease, stroke or spinal cord injury commonly featu
Autor:
Petr Beneš, Roman Huley, Monika Dúcka, Taras Gutor, Orest Petronchak, Lucia Knopfová, Lubor Borsig, Nataliya Volodko, Jan Šmarda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Tumor-associated macrophages (TAMs) are prominent components of tumor stroma that promotes tumorigenesis. Many soluble factors participate in the deleterious cross-talk between TAMs and transformed cells; however mechanisms how tumors orchestrate the
Autor:
Petr Beneš, Jiří Jarkovský, Jana Katolická, Ivan Čapov, Jan Šmarda, Petr Vlček, Tichý M, Markéta Hermanová, Lucia Knopfová
Publikováno v:
Journal of Cancer
Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expr
Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma
Autor:
Lenka Veverková, Jiří Jarkovský, Ivan Čapov, Petr Beneš, Jana Katolická, Jan Šmarda, Markéta Hermanová, Lucie Pekarčíková, Petr Vlček, Tichý M, Lucia Knopfová
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis.
Publikováno v:
Cellular signalling
The c-Myb transcription factor is important for maintenance of immature cells of many tissues including colon epithelium. Overexpression of c-Myb occurring in colorectal carcinomas (CRC) as well as in other cancers often marks poor prognosis. However
Autor:
Lubor Borsig, Cristina Stefanescu, Lucia Knopfová, Jesus Francisco Glaus Garzon, Darya Protsyuk, Christian Gorzelanny, Bruno Luckow, Marko Roblek, Stefan W. Schneider, Mathias Heikenwalder, Paul F. Becker
Publikováno v:
Mol. Cancer Res. 17, 783-793 (2019)
Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation, but the functionality remai
Autor:
Sára Lenárt, Šárka Šimečková, Radek Fedr, Zuzana Kahounová, Jan Bouchal, Petr Beneš, Gvantsa Kharaishvili, Lucia Binó, Eva Slabáková, Milan Král, Tereza Kučírková, Ján Remšík, Lucia Knopfová, Karel Souček, Ximena Maria Muresan
Publikováno v:
Carcinogenesis. 39(11)
The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype i
Autor:
Kateřina Kaňková, Katarína Chalásová, Lucia Knopfová, Josef Tomandl, Lukáš Pácal, Jitka Řehořová, Marie Tomandlová, Anna Pleskačová
Publikováno v:
Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 126(4)
Aim Pentose phosphate pathway (PPP) with key enzyme transketolase (TKT), represents a potentially ‘protective’ mechanism in hyperglycaemia. Diabetic kidney disease (DKD), a common complication of both type 1 and type 2 diabetes associated with si
Autor:
Vojtech Adam, Petr Babula, Monika Holubová, Martina Raudenská, Markéta Sztalmachová, Michal Masarik, Jaromír Gumulec, Jan Balvan, Hana Polanska, René Kizek, Lucia Knopfová, Kristyna Hudcova
Publikováno v:
International Journal of Oncology. 46:1810-1818
Breast cancer patients negative for the nuclear oestrogen receptor α have a particularly poor prognosis. Therefore, the 4T1 cell line (considered as a triple-negative model) was chosen to induce malignancy in mice. The aim of the present study was t
Publikováno v:
Klinicka onkologie. 27:S22-S27
Migration and invasiveness are phenotypic characteristics of cells that contribute to physiological processes, such as wound healing or embryogenesis and they are involved in serious pathological processes, namely in tumor cell metastasis. Availabili