Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Leonardo Guasti"'
Autor:
Nicole Reisch, Walter L. Miller, Wiebke Arlt, Angela Huebner, Stefan A. Wudy, Phyllis W. Speiser, Nike M. M. L. Stikkelbroeck, Richard J. Auchus, Hedi L Claahsen-van der Grinten, Anna Nordenström, Deborah P. Merke, Perrin C. White, Nils Krone, S Faisal Ahmed, Henrik Falhammar, Barbara B.M. Kortmann, Christa E. Flück, David E. Sandberg, Agustini Utari, Leonardo Guasti, Philippe Touraine
Publikováno v:
Endocrine Reviews, 43, 91-159
Endocrine Reviews, 43, 1, pp. 91-159
Endocr Rev
Endocrine Reviews, 43, 1, pp. 91-159
Endocr Rev
Contains fulltext : 244176.pdf (Publisher’s version ) (Closed access) Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c23cf57c7fd950799c666e0dbe3d370
http://hdl.handle.net/2066/244176
http://hdl.handle.net/2066/244176
Publikováno v:
Endocrine-related cancer. 28(12)
Delta-like non-canonical Notch ligand 1 (DLK1) is a cleavable single-pass transmembrane protein and a member of the Notch/Delta/Serrate family. It is paternally expressed and belongs to a group of imprinted genes located on chromosome band 14q32 in h
Publikováno v:
Curr Opin Endocr Metab Res
Since the original description of adrenal insufficiency by Thomas Addison in 1855, there has been an exponential growth in the understanding of adrenal gland biology and its role in the hypothalamic-pituitary-adrenal axis. Despite this, the mainstay
Autor:
Leonardo Guasti, Katia Mariniello
Publikováno v:
Molecular and cellular endocrinology. 524
Adrenal insufficiency, the inability to produce adequate levels of corticosteroids, is a multi-causal disease that requires lifelong daily hormone replacement. Nevertheless, this cannot replace the physiological demand for steroids which are secreted
Autor:
Leonardo Guasti, Tatiana V. Novoselova, Adrian J. L. Clark, Li F. Chan, Peter J. King, Louise A. Metherell
Publikováno v:
Endocrine Connections
Endocrine Connections, Vol 8, Iss 7, Pp R122-R130 (2019)
Endocrine Connections, Vol 8, Iss 7, Pp R122-R130 (2019)
The melanocortin-2-receptor (MC2R), also known as the ACTH receptor, is a critical component of the hypothalamic–pituitary–adrenal axis. The importance of MC2R in adrenal physiology is exemplified by the condition familial glucocorticoid deficien
Autor:
Li F. Chan, Avinaash Maharaj, Louise A. Metherell, Ashwini Maudhoo, Leonardo Guasti, Tatiana V. Novoselova, Rathi Prasad
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 189
Hereditary adrenocorticotropin (ACTH) resistance syndromes encompass the genetically heterogeneous isolated or Familial Glucocorticoid Deficiency (FGD) and the distinct clinical entity known as Triple A syndrome. The molecular basis of adrenal resist
Autor:
Gerard Ruiz-Babot, Alessandra Mancini, Demetris Mariannis, Teng-Teng Chung, Tarek Ezzat Abdel-Aziz, Leonardo Guasti, Peter J. King, Fausto Palazzo, Irene Hadjidemetriou, Katja Kiseljak-Vassiliades, Margaret E. Wierman, William Drake, Aimee diMarco, Laila Parvanta, James Pittaway, Celso E. Gomez-Sanchez, Katia Mariniello
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 193
The adrenal cortex governs fundamental metabolic processes though synthesis of glucocorticoid, miner-alocorticoids and androgens. Studies in rodents have demonstrated that the cortex undergoes a self-renewal process and that capsular/subcapsular stem
Autor:
James Pittaway, Leonardo Guasti
Publikováno v:
Journal of molecular endocrinology. 62(2)
Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence worldwide of 0.7–2.0 cases/million/year. Initial staging is the most important factor in determining prognosis. If diagnosed early, complete surgical resection +/− adjuvant tre
Autor:
Maralyn Druce, Evelien F. Gevers, Mariya Balyura, Peter J. King, Gerard Ruiz-Babot, Leonardo Guasti, Irene Hadjidemetriou, Sharon Ajodha, Umasuthan Srirangalingam, David R Taylor, Lea Ghataore, Stefan R. Bornstein, Gerard S. Conway, Louise A. Metherell, William Drake, Helen L Storr, Undine Schubert, Norman F. Taylor
Publikováno v:
SSRN Electronic Journal.
Adrenal insufficiency is managed by hormone replacement therapy, which is far from optimal; the ability to generate functional steroidogenic cells would offer a unique opportunity for a curative approach restoring the complex feedback regulation of t
Autor:
Leonardo Guasti
Publikováno v:
Endocrine Abstracts.