Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Karsten Krug"'
Autor:
Cynthia X. Ma, Foluso O. Ademuyiwa, Mothaffar F. Rimawi, Meenakshi Anurag, Chen Huang, Michael A. Gillette, Terry Hyslop, Jeremy Hoog, Yongchao Dou, Alexander B. Saltzman, Eric J. Jaehnig, Rachel Schiff, Suhas Vasaikar, Mark A. Watson, Doug W. Chan, D. R. Mani, Karl R. Clauser, Bo Wen, Beom-Jun Kim, Karsten Krug, Anna Malovannaya, Ari Gao, David G. Mutch, Shankha Satpathy, Kimberly R. Holloway, Bing Zhang, Samuel Jacobs, Steven A. Carr, Matthew J. Ellis, Purba Singh, Charles M. Perou, George Miles, Noel Namai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by integrating genomics, transcriptomics and protein profiling including modifications by mass spectrometry (MS). A critical limitation is sample input requirement
Autor:
Michael Burgess, Özgün Babur, Tomas Rejtar, Meagan E. Olive, E. Robert McDonald, Dominique Forestier, Filip Mundt, Michael A. Gillette, Dale Porter, Pierre M. Jean Beltran, Steven A. Carr, Ellen Todres, Luke Wallace, Karen Wang, Javad Golji, Karsten Krug, Mani, Melanie A. MacMullan, Sara E Marlow, Randy Melanson, Judit Jané-Valbuena, Margaret Lea Robinson, Eric Kuhn, William R. Sellers, Harrison Specht, Hasmik Keshishian, Shankha Satpathy, Bokang Rabasha
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here, we present SigPath, a targeted mass spectro
Autor:
D. R. Mani, Ian S. Hagemann, Ana I. Robles, Meenakshi Anurag, Gloria V. Echeverria, Shankha Satpathy, Cathy Sullivan, Kristen Otte, Karsten Krug, Erik J. Bergstrom, Henry Rodriguez, Beom-Jun Kim, Steven A. Carr, Eric J. Jaehnig, Yongchao Dou, Foluso O. Ademuyiwa, Mothaffar F. Rimawi, Michael T. Lewis, Jonathan T. Lei, Michael A. Gillette, Matthew J. Ellis, Bing Zhang
Publikováno v:
Cancer Chemistry.
Introduction: There are no robust molecular predictors for response of TNBC to chemotherapy. Microscaled proteogenomics (PMC6985126) was therefore applied to biopsies from TNBC patients undergoing neoadjuvant carboplatin/docetaxel. Approach: Sufficie
Autor:
D. Forestier, Levi A. Garraway, S. E. Marlow, Michael A. Gillette, Tomas Rejtar, Dale Porter, William R. Sellers, D. R. Mani, F. Mundth, Luke Wallace, Shankha Satpathy, Keshi Wang, Harrison Specht, Judit Jané-Valbuena, Earl Mcdonald, Bokang Rabasha, Randy Melanson, Karsten Krug, Eric Kuhn, Karl R. Clauser, Michael Burgess, Javad Golji, Hasmik Keshishian, Steven A. Carr, Melanie A. MacMullan, Ellen Todres
Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug-treatment in cells and tissues but are presently lacking. Here we present SigPath, a targeted mass spectrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a15728a4ae35bee30ef6a6bbf1c7615
https://doi.org/10.1101/2020.12.08.415281
https://doi.org/10.1101/2020.12.08.415281
Autor:
Shuang Cai, Elizabeth R. Duffy, Felipe da Veiga Leprevost, D. R. Mani, Antonio Colaprico, Jiayi Ji, Mehdi Mesri, Alicia Francis, Peter B. McGarvey, Myvizhi Esai Selvan, Corbin D. Jones, Michael J. Birrer, Robert J. Welsh, Lori Bernard, Shankha Satpathy, Li Ding, Sara R. Savage, Eugene S. Fedorov, Fernanda Martins Rodrigues, Marcin J. Domagalski, Jennifer M. Eschbacher, Shayan C. Avanessian, Boris Reva, Harsh Batra, Suhas Vasaikar, Nathan Edwards, Michael A. Gillette, Chet Birger, Scott D. Jewell, Kei Suzuki, William Bocik, Shilpi Singh, Meenakshi Anurag, Karen E. Christianson, Namrata D. Udeshi, Vasileios Stathias, Warren G. Tourtellotte, Karl R. Clauser, Shutack, Andrii Karnuta, Dana R. Valley, Kelly V. Ruggles, Qing Kay Li, Amanda G. Paulovich, MacIntosh Cornwell, Shankara Anand, Bartosz Kubisa, Pierre M. Jean Beltran, James Suh, Gilbert S. Omenn, Azra Krek, Wohaib Hasan, Yongchao Dou, David Fenyö, Henry Rodriguez, Samuel H. Payne, Małgorzata Wojtyś, Daniel W. Chan, Bo Wen, Nicollette Maunganidze, Özgün Babur, Renganayaki Pandurengan, Karen A. Ketchum, Nikolay Gabrovski, Pankaj Vats, Saravana M. Dhanasekaran, Richard D. Smith, Gad Getz, Sailaja Mareedu, Yuxing Liao, Mikhail Krotevich, Hui Zhang, Eric J. Jaehnig, Charles A. Goldthwaite, Alexey I. Nesvizhskii, Katherine A. Hoadley, Alexander A. Green, Francesca Petralia, Chandan Kumar-Sinha, Karsten Krug, Eunkyung An, Elena V. Ponomareva, Ximing Tang, Nancy Roche, Daniel C. Rohrer, David I. Heiman, Arul M. Chinnaiyan, Pamela Grady, Rebecca I. Montgomery, Galen Hostetter, Liqun Qi, Stephan C. Schürer, George D. Wilson, Pushpa Hariharan, Zhen Zhang, Yvonne, David Chesla, Chia-Kuei Mo, Maria Gabriela Raso, Negin Vatanian, Paul K. Paik, Fei Ding, Thomas L. Bauer, Barbara Hindenach, Matthew J. Ellis, Chen Huang, Karin D. Rodland, Oluwole Fadare, Ramaswamy Govindan, Eric E. Schadt, Sandra Cottingham, Barbara Pruetz, Sendurai A. Mani, Shirley Tsang, Carissa Huynh, Weiping Ma, Jennifer E. Maas, Tobias Schraink, Stacey Gabriel, Bing Zhang, Tara Hiltke, Rama Soundararajan, Tatiana Omelchenko, Brian J. Druker, Matthew A. Wyczalkowski, Neil R. Mucci, Ziad Hanhan, Donna E. Hansel, Yifat Geffen, Mathangi Thiagarajan, Xiaojun Jing, Pei Wang, Alfredo Molinolo, Tanmayi Vashist, Ratna R. Thangudu, Maciej Wiznerowicz, Edwin R. Parra, Tanvi H. Visal, Maureen Dyer, Melissa Borucki, Ki Sung Um, Jonathan T. Lei, Marcin Cieslik, Christopher R. Kinsinger, M. Harry Kane, Houxiang Zhu, Chelsea J. Newton, Steven A. Carr, Tao Liu, Wenke Liu, Volodymyr Sovenko, Olga Potapova, Eric J. Burks, Song Cao, Ana I. Robles, Yuping Zhang, Yize Li, Midie Xu, Erik J. Bergstrom, Zeynep H. Gümüş, Kai Li, Xiaoyu Song
Publikováno v:
Cell
Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a deeper exposition of LSCC biology with potential therapeutic implications. We
Autor:
Lewis C. Cantley, Karl Clauser, Tommer M. Yaron, Steven A. Carr, David I. Heiman, Shankara Anand, Yifat Geffen, Alexander Kerelsky, Yo Akiyama, Chet Birger, François Aguet, Dinesh Mani, Gad Getz, Jared L. Johnson, Oncogenic Drivers, Michael A. Gillette, Shankha Satpathy, Karsten Krug
Publikováno v:
Cancer Research. 81:16-16
Post-translational modifications (PTMs) (e.g., ubiquitylation, phosphorylation, acetylation) have been studied for their key role in cell signaling and in regulating cell physiology. Advances in mass spectrometry now enable measuring PTMs and studyin
Autor:
Tara Skelly, Wen Jiang, Zhen Zhang, Anupriya Agarwal, Amy M. Perou, Olga Potapova, Christopher R. Kinsinger, Matthew A. Wyczalkowski, David J. Clark, Shuang Cai, Felipe da Veiga Leprevost, Linda Hannick, Chen Huang, Paul D. Piehowski, John McGee, Marcin J. Domagalski, Dmitris Placantonakis, Jianbo Pan, Dana R. Valley, Zhiao Shi, Hui Yin Chang, Karen A. Ketchum, Charles A. Goldthwaite, Małgorzata Wierzbicka, Karsten Krug, Yvonne Shutack, Sara R. Savage, Matthew L. Anderson, Alyssa Charamut, Chandan Kumar-Sinha, Sanford P. Markey, Ratna R. Thangudu, Weiping Ma, Oliver F. Bathe, Antonio Colaprico, Yuxing Liao, Eric E. Schadt, Tomasz Czernicki, Seungyeul Yoo, Xi Chen, Stacey Gabriel, Karl R. Clauser, Daniel C. Rohrer, Uma Borate, Uma Velvulou, Larisa Polonskaya, M. Harry Kane, Dmitry M. Avtonomov, Boris Reva, Jacob J. Day, Barbara Hindenach, Matthew J. Ellis, Katherine A. Hoadley, Emek Demir, Rebecca I. Montgomery, Ewa P. Malc, Fengchao Yu, Lijun Yao, Maciej Wiznerowicz, Annette Marrero-Oliveras, Wojciech Szopa, Sailaja Mareedu, Galen Hostetter, Liqun Qi, Hui Zhang, Yige Wu, David N. Hayes, Shankha Satpathy, Corbin D. Jones, Michael J. Birrer, Xinpei Yi, Nathan Edwards, Fei Ding, Jiang Qian, Ning Qu, Alicia Francis, Daniel Cui Zhou, Jakub Stawicki, Bing Zhang, Rodrigo Vargas Eguez, Tao Liu, Dave Tabor, Maureen Dyer, Brian J. Druker, Gilbert S. Omenn, Azra Krek, Meenakshi Anurag, Melissa Borucki, Mathangi Thiagarajan, Shirley Tsang, Shakti Ramkissoon, Alexey I. Nesvizhskii, Li Ding, Lyubomir Valkov Vasilev, Yifat Geffen, James Suh, Tatiana S. Ermakova, Kakhaber Zaalishvili, Adel K. El-Naggar, Ki Sung Um, Ana I. Robles, Wen-Wei Liang, Richard D. Smith, Pei Wang, Emily S. Boja, Anna Calinawan, Yingwei Hu, Jiayi Ji, Renata Ferrarotto, Hongwei Liu, Jonathan T. Lei, Ramani B. Kothadia, Yize Li, Chelsea J. Newton, Anna Malovannaya, Steven A. Carr, Sandra Cerda, Yuriy Zakhartsev, Stephanie De Young, Eric J. Jaehnig, Peter B. McGarvey, Yan Shi, David I. Heiman, Joseph C. Dort, Karin D. Rodland, Lili Blumenberg, Michael A. Gillette, Piotr A. Mieczkowski, Pankaj Vats, Chet Birger, Yongchao Dou, David Fenyö, Saravana M. Dhanasekaran, Pushpa Hariharan, Eunkyung An, Jeffrey R. Whiteaker, George Miles, Jan Lubinski, Shayan C. Avanessian, Samuel H. Payne, Amanda G. Paulovich, Dmitry Rykunov, Lyudmila Petrenko, Martin Hyrcza, Guo Ci Teo, Alissa M. Weaver, D. R. Mani, Houston Culpepper, Meghan C. Burke, Daniel W. Chan, Bo Wen, Nicollette Maunganidze, Elie Traer, Darlene Tansil, Simona Migliozzi, Luciano Garofano, Qing Kay Li, Donghui Tan, Lori J. Sokoll, Mehdi Mesri, Karna Robinson, Fulvio D'Angelo, Kimberly Elburn, Alexander R. Pico, Umut Ozbek, Michael Schnaubelt, Gad Getz, Francesca Petralia, Andrew G. Sikora, Kai Li, Elena V. Ponomareva, Arul M. Chinnaiyan, Robert Zelt, Jun Zhu, Midie Xu, Dimitar Dimitrov Pazardzhikliev, Negin Vatanian, Grace Zhao, Thomas F. Westbrook, Kyung-Cho Cho, Yuefan Wang, Jason E. McDermott, Jeffrey W. Tyner, William Bocik, Shilpi Singh, Stephen E. Stein, Nancy Roche, Alicia Karz, Shannon Richey, Tara Hiltke, Michael Vernon, Lijun Chen, Henry Rodriguez, Xiaoyu Song, Elizabeth R. Duffy, Lin S. Chen, Liwei Cao, Shrabanti Chowdhury, Marcin Cieślik, Michael C. Wendl, Scott D. Jewell, Cristina E. Tognon
Publikováno v:
Cancer Cell
We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs HNSCC-associated proteins and phosphosites, prioritizes copy number drivers, and
Autor:
Li Ding, Shankha Satpathy, Alla Karpova, Philipp Mertins, Lili Blumenberg, Karl R. Clauser, Bing Zhang, Karsten Krug, Ramani Kothadia, MJ Ellis, Mani, Eric J. Jaehnig, Kelly V. Ruggles, Steven A. Carr, Lauren C. Tang, Michael A. Gillette
Publikováno v:
Cancer Research. 80:TS1-2
A persistent central deficiency in our knowledge of cancer concerns how genomic changes drive the proteome and phosphoproteome to execute phenotypic characteristics. Furthermore increasing evidence implicating epigenetic and post-translational change
Autor:
Matthew E. Monroe, Saravana M. Dhanasekaran, Brian R. Rood, Zeynep H. Gümüş, Jena Lilly, Samuel G. Winebrake, Richard G. Ivey, William Bocik, Mahdi Sarmady, Alicia Francis, Lamiya Tauhid, Nathan Edwards, Lizabeth Katsnelson, Rui Zhao, Matilda Broberg, Jo Lynne Rokita, Mateusz Koptyra, Henry Rodriguez, Cassie Kline, Shrabanti Chowdhury, Nicole Tignor, Ying Wang, Christopher R. Kinsinger, Antonio Colaprico, Amanda G. Paulovich, Weiping Ma, Emily S. Boja, Tara Hiltke, Sabine Mueller, Liang-Bo Wang, Javad Nazarian, Marcin J. Domagalski, Karl K. Weitz, Jessica B. Foster, Robert Lober, Carina A. Leonard, Bo Zhang, Gerald A. Grant, Anna Calinawan, Gonzalo Lopez, Shuang Cai, Joanna J. Phillips, Guo Ci Teo, July E. Palma, Felipe da Veiga Leprevost, Yiran Guo, Angela Waanders, Xiaoyu Song, Li Ding, Allison Heath, Steven P. Gygi, Rosalie K. Chu, Vasileios Stathias, Bailey Farrow, Oren J. Becher, Dmitry Rykunov, Nithin D. Adappa, Ron Firestein, Adam C. Resnick, Marcin Cieślik, Jennifer Mason, D. R. Mani, Selim Kalayci, Boris Reva, Antonio Iavarone, MacIntosh Cornwell, Uliana J. Voytovich, Gabrielle S. Stone, Miguel A. Brown, Jacob J. Kennedy, Tao Liu, Ronald J. Moore, Emily Kawaler, Eric H. Raabe, Marina A. Gritsenko, Valerie Baubet, Francesca Petralia, Maciej Wiznerowicz, Olena Morozova Vaske, Eric E. Schadt, Ian F. Pollack, Arul M. Chinnaiyan, Meghan Connors, Jason E. Cain, Lei Zhao, Matthew A. Wyczalkowski, Nalin Gupta, Bing Zhang, Jiayi Ji, Marilyn M. Li, Samuel Rivero-Hinojosa, Mariarita Santi, Wenke Liu, John Szpyt, Brian Ennis, Alexey I. Nesvizhskii, Joshua M. Wang, Jeffrey P. Greenfield, Sanjukta Guha Thakurta, Hui Yin Chang, Peter B. McGarvey, Xi Chen, Karen A. Ketchum, Stephan C. Schürer, Sarah Leary, Lili Blumenberg, Matthew J. Ellis, Pei Wang, Anna Maria Buccoliero, Karsten Krug, Chiara Caporalini, Gad Getz, David E. Kram, Pichai Raman, Eric M. Jackson, James N. Palmer, Mehdi Mesri, Kelly V. Ruggles, Chunde Li, Jun Zhu, Sonia Partap, Jeffrey R. Whiteaker, Mirko Scagnet, Krutika S. Gaonkar, Azra Krek, Allison M. Morgan, Tatiana Omelchenko, Richard D. Smith, Elizabeth Appert, Karin D. Rodland, Derek Hanson, Phillip B. Storm, Jamie Moon, Vladislav A. Petyuk, Nathan Young, Travis D. Lorentzen, David Fenyö, Angela N. Viaene, Seungyeul Yoo, Yuankun Zhu, Nicholas A Vitanza, Toan Le, Tatiana Patton, Ana I. Robles
Publikováno v:
Cell
We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 histological types of childhood brain cancer: low-grade glioma (n = 93), epen
Autor:
Zhe Ji, Ginevra Botta, Todd R. Golub, Victor Luria, Joshua M. Dempster, Nicholas J. Lyons, Briana Fritchman, Federica Piccioni, Karolina Stumbraite, Karl R. Clauser, Jacob D. Jaffe, Zohra Kalani, David E. Root, Vickie M. Wang, Li Wang, Douglas Alan, Oana M. Enache, Adam Brown, Marc W. Kirschner, Jennifer Roth, Thomas M Green, Karsten Krug, John R. Prensner, Amy Goodale, Xiaoping Yang, Amir Karger
Publikováno v:
Neuro-Oncology
The brain is the foremost non-gonadal tissue for expression of non-coding RNAs of unclear function. Yet, whether such transcripts are truly non-coding or rather the source of non-canonical protein translation is unknown. Here, we used functional geno