Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karen-Amanda Irvine"'
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
High rates of acute and chronic pain are associated with traumatic brain injury (TBI), but mechanisms responsible for the association remain elusive. Recent data suggest dysregulated descending pain modulation circuitry could be involved. Based on th
Autor:
Nikos Kyritsis, Jacqueline C. Bresnahan, Karen-Amanda Irvine, John C. Gensel, Rajiv R. Ratan, Jessica L. Nielson, Michael C. Oldham, J.R. Huie, Mark R. Segal, Michael S. Beattie, Jonathan Z. Pan, Amity Lin, Adam R. Ferguson, Patrick G. Schupp
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
SUMMARYTraumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d88e3e42b981826baf038dde7aa4fd2
https://escholarship.org/uc/item/75d653j4
https://escholarship.org/uc/item/75d653j4
Autor:
S. Scott Panter, Seok Joon Won, Giordano Fabricio Cittolin-Santos, Robin K Bishop, Eric Rome, Karen-Amanda Irvine, Jayinee Basu, Jianguo Xu, Raymond A. Swanson, Katherine A. Hamel, Andrew Sondag, Valerie G. Coppes, Pardeep Singh
Publikováno v:
Journal of neurotrauma, vol 35, iss 7
The inflammation response induced by brain trauma can impair recovery. This response requires several hours to develop fully and thus provides a clinically relevant therapeutic window of opportunity. Poly(ADP-ribose) polymerase inhibitors suppress in
Autor:
Xiaoyou Shi, Anders Christian Meidahl, Yuan Sun, Peng Liu, De-Yong Liang, Karen-Amanda Irvine, Peyman Sahbaie, J. David Clark, David C. Yeomans, Tian-Zhi Guo
Publikováno v:
IBRO Reports, Vol 2, Iss C, Pp 14-23 (2017)
IBRO Reports
IBRO Reports
Chronic pain after traumatic brain injury (TBI) is very common, but the mechanisms linking TBI to pain and the pain-related interactions of TBI with peripheral injuries are poorly understood. In these studies we pursued the hypothesis that TBI pain s
Publikováno v:
Experimental Neurology. 320:112976
Acute and persistent pain are recognized consequences of TBI that can enhance suffering and significantly impair rehabilitative efforts. Both experimental models and clinical studies suggest that TBI may result in an imbalance between descending pain
Publikováno v:
Journal of neurotrauma. 35(13)
Chronic pain is a common consequence of traumatic brain injury (TBI) that can increase the suffering of a patient and pose a significant challenge to rehabilitative efforts. Unfortunately, the mechanisms linking TBI to pain are poorly understood, and
Autor:
J. David Clark, Karen-Amanda Irvine
Publikováno v:
Pain medicine (Malden, Mass.). 19(7)
Background Traumatic brain injury refers to a broad range of neurological, cognitive, and emotional factors that result from the application of an external force to the head. Individuals recovering from traumatic brain injury will frequently experien
Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury
Autor:
Karen-Amanda Irvine, Aiwen W. Liu, Jesse Paquette, Geoffrey T. Manley, Adam R. Ferguson, C. Amy Tovar, Jacqueline C. Bresnahan, Wise Young, Tanya C. Petrossian, Jennifer Kloke, Cristian F. Guandique, Michael S. Beattie, John C. Gensel, Gunnar E. Carlsson, Tomoo Inoue, Pek Yee Lum, Jessica L. Nielson
Publikováno v:
Nature communications, vol 6, iss 1
Nature Communications
Nature Communications
Data-driven discovery in complex neurological disorders has potential to extract meaningful syndromic knowledge from large, heterogeneous data sets to enhance potential for precision medicine. Here we describe the application of topological data anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1db33daac087d1219fed5a0c3f93268
https://escholarship.org/uc/item/7pc77332
https://escholarship.org/uc/item/7pc77332
Autor:
Adam R. Ferguson, James W. Grau, Jacqueline C. Bresnahan, Michael S. Beattie, J. Russell Huie, Ellen D. Stuck, Karen-Amanda Irvine, Kuan H. Lee
Publikováno v:
eNeuro, vol 2, iss 5
eNeuro
eNeuro
Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms. Perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a315aa9641201d343cd648b3adde770f
https://escholarship.org/uc/item/8wd9z71h
https://escholarship.org/uc/item/8wd9z71h
Autor:
David H. Rowitch, Sovann Kaing, Chao Zhao, Dong-in Yuk, Sergio E. Baranzini, Nader Sanai, Karen-Amanda Irvine, Robin J.M. Franklin, Stephen P.J. Fancy
Publikováno v:
Genes & Development. 23:1571-1585
The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of