Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kalvis Hornburg"'
Autor:
Robert A. Redd, Matthew Leventhal, Irene M. Ghobrial, Nikhil C. Munshi, Christopher J. Gibson, Jerome Ritz, Amin Nassar, Chip Stewart, Jihye Park, Romanos Sklavenitis-Pistofidis, Marzia Capelletti, Cody J. Boehner, David P. Steensma, Saud H. AlDubayan, Daniel Auclair, Lorenzo Trippa, Muhieddine M. Itani, Benjamin L. Ebert, Kalvis Hornburg, Shaadi Mehr, Mark Bustoros, Robert L. Schlossman, Henry Dumke, Jacob P. Laubach, Adam S. Sperling, Gad Getz, Salomon Manier, Paul G. Richardson, Eliezer M. Van Allen, Tarek H. Mouhieddine, Sabrin Tahri, Kenneth C. Anderson, Robert J. Soiffer, Daisy Huynh, Donna Neuberg, Brendan Reardon, Chia Jen Liu, Jonathan J Keats
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is t
Autor:
Peter Sabbatini, Stacey Chuma, Rachid Baz, Jacob P. Laubach, Robert A. Redd, Alexandra Savell, Raymond P. Perez, Pamela S. Becker, Patrick Henrick, Kenneth C. Anderson, Oksana Zavidij, Chia Jen Liu, Kalvis Hornburg, Romanos Sklavenitis-Pistofidis, Michael Robbins, Kaitlen Reyes, Paul G. Richardson, Irene M. Ghobrial
Publikováno v:
Clinical Cancer Research. 26:344-353
Purpose: Ulocuplumab (BMS-936564) is a first-in-class fully human IgG4 monoclonal anti-CXCR4 antibody that inhibits the binding of CXCR4 to CXCL12. Patients and Methods: This phase Ib/II study aimed to determine the safety and tolerability of ulocupl
Autor:
Edie Weller, Kaitlen Reyes, James J. Vredenburgh, Adam Boruchov, Kimberly Noonan, Paul G. Richardson, Rachid Baz, Jacob P. Laubach, Abdel Kareem Azab, Houry Leblebjian, Robert L. Schlossman, Irene M. Ghobrial, Frank G. Basile, Pamela A. Crilley, Kenneth C. Anderson, Patrick Henrick, Michael Constantine, Stacey Chuma, Nikhil C. Munshi, Kenneth H. Shain, Kalvis Hornburg, Claudia E. Paba-Prada, Philippe Armand, Diane Warren, Yuji Mishima, Lorenzo Trippa, Chia Jen Liu, Oksana Zavidij
Publikováno v:
American Journal of Hematology. 94:1244-1253
We tested the hypothesis that using CXCR4 inhibition to target the interaction between the tumor cells and the microenvironment leads to sensitization of the tumor cells to apoptosis. Eligibility criteria included multiple myeloma (MM) patients with
Autor:
Philippe Armand, Damian R. Handisides, Irene M. Ghobrial, Jacalyn Rosenblatt, Kenneth C. Anderson, Jacquelyn Hedlund, Paul G. Richardson, Henry Dumke, Bradley Rivotto, Stacey Chuma, Robert L. Schlossman, Kenneth H. Shain, Stew Kroll, Patrick Henrick, Chia Jen Liu, Noopur Raje, Michael Gary Martin, Alexandra Savell, Andrew Yee, Craig Reynolds, Kalvis Hornburg, Laura Stampleman, Jacob P. Laubach, Ira Zackon
Publikováno v:
Clinical Cancer Research. 25:478-486
Purpose: The presence of hypoxia in the diseased bone marrow presents a new therapeutic target for multiple myeloma. Evofosfamide (formerly TH-302) is a 2-nitroimidazole prodrug of the DNA alkylator, bromo-isophosphoramide mustard, which is selective
Autor:
David Liu, Kalvis Hornburg, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial, Stephen M. Ansell, Jorge J. Castillo, Maria Gavriatopoulou, Saurabh Zanwar, Efstathios Kastritis, Geoffrey Fell, Joseph Cappuccio, Lorenzo Trippa, Robert A. Kyle, Robert J. Soiffer, Carl Jannes Neuse, Henry Dumke, Jithma P. Abeykoon, Mark Bustoros, Catherine R. Marinac, Jenny Soiffer, Meletios A. Dimopoulos, Chia Jen Liu, Steven P. Treon, Prashant Kapoor, Cody J. Boehner, Kaitlen Reyes
Publikováno v:
J Clin Oncol
BACKGROUND Waldenström macroglobulinemia (WM) is preceded by asymptomatic WM (AWM), for which the risk of progression to overt disease is not well defined. METHODS We studied 439 patients with AWM, who were diagnosed and observed at Dana-Farber Canc
Autor:
Romanos Sklavenitis-Pistofidis, Jacob P. Laubach, Bradley Rivotto, Magdalini Migkou, Irene M. Ghobrial, Maria Gavriatopoulou, Geon Kim, David Liu, Paul G. Richardson, Kalvis Hornburg, Kimberly Noonan, Carl Jannes Neuse, Dimitrios C. Ziogas, Mark Bustoros, Nikolaos Kanellias, Evangelos Terpos, Maria Roussou, Catherine R. Marinac, Kaitlen Reyes, Chia Jen Liu, Efstathios Kastritis, Kenneth C. Anderson, Meletios A. Dimopoulos
Publikováno v:
American Journal of Hematology. 94
Autor:
Jonathan J Keats, Henry Dumke, Brendan Reardon, Daniel Auclair, Donna Neuberg, Kalvis Hornburg, Romanos Sklavenitis-Pistofidis, Nikhil C. Munshi, Christopher J. Gibson, Marzia Capelletti, Jacob P. Laubach, Paul G. Richardson, Robert L. Schlossman, Amin Nassar, David P. Steensma, Matthew Leventhal, Robert A. Redd, Chip Stewart, Irene M. Ghobrial, Jerome Ritz, Cody J. Boehner, Muhieddine M. Itani, Salomon Manier, Daisy Huynh, Jihye Park, Eliezer M. Van Allen, Saud H. AlDubayan, Benjamin L. Ebert, Kenneth C. Anderson, Sabrin Tahri, Mark Bustoros, Tarek H. Mouhieddine, Robert J. Soiffer, Shaadi Mehr, Adam S. Sperling, Gad Getz, Chia Jen Liu
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 19:e15
Autor:
Peter Sabbatini, Stacey Chuma, Alexandra Savell, Patrick Henrick, Irene M. Ghobrial, Kenneth C. Anderson, Jacob P. Laubach, Chia Jen Liu, Kaitlen Reyes, Raymond P. Perez, Paul G. Richardson, Pamela S. Becker, Kalvis Hornburg
Publikováno v:
Blood. 132:3263-3263
Background : CXCR4 is a chemokine receptor over-expressed on > 75% of cancers, including malignant plasma cells. Ulocuplumab (BMS- 936564) is a first in class, fully human IgG4 monoclonal anti-CXCR4 antibody which inhibits the binding of CXCR4 to CXC
Autor:
Kalvis Hornburg, David M. Dorfman, Gad Getz, Brianna Berrios, Jihye Park, Bradley Rivotto, Adriana Perilla-Glen, Mahshid Rahmat, Mairead Reidy, Mark Bustoros, Nicholas J. Haradhvala, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial, Jonathan D. Licht, Daisy Huynh
Publikováno v:
Blood. 132:3896-3896
Introduction. Multiple myeloma (MM) is a complex and heterogeneous malignancy of plasma cells that has two precursor states: monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). MGUS and SMM are asymptomati
Autor:
Geoffrey Fell, Patrick Henrick, Efstathios Kastritis, Romanos Sklavenitis-Pistofidis, Steven P. Treon, David Liu, Robert J. Soiffer, Carl-Jannes Neuse, Kalvis Hornburg, Kimberly Noonan, Jorge J. Castillo, Meletios A. Dimopoulos, Mark Bustoros, Chia Jen Liu, Adriana Perilla-Glen, Irene M. Ghobrial, Henry Dumke, Jenny Soiffer, Catherine R. Marinac, Alexandra Savell, Bradley Rivotto, Cody J. Boehner, Amir Yosef, Kaitlen Reyes
Publikováno v:
Blood. 132:150-150
Background. Waldenström macroglobulinemia (WM) is a low-grade non-Hodgkin's lymphoplasmacytic lymphoma associated with overproduction of monoclonal IgM protein. It is preceded by an asymptomatic stage, called Smoldering Waldenström Macroglobulinemi