Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Kah-Leong Lim"'
Autor:
Venetia Kok Jing Tong, Sylvester Wong Shu Ming, Kah-Leong Lim, Ziyin Wang, Rafhanah Banu Bte Abdul Razar, Saravanan Gunaseelan, Sumitra Srimasorn, Wei-Yi Ong, John Jia En Chua
Publikováno v:
Human Molecular Genetics. 30:5-20
FEZ1-mediated axonal transport plays important roles in central nervous system development but its involvement in the peripheral nervous system is not well-characterized. FEZ1 is deleted in Jacobsen syndrome (JS), an 11q terminal deletion development
Autor:
Zhipeng Liu, Zheng Li, Chengwu Zhang, Chonglei Ji, Mazen S.S. Shaibani, Lin Li, Qian Sun, Jiajia Xu, Kah-Leong Lim
Publikováno v:
Analytical Chemistry. 92:4038-4045
Parkinson's disease (PD) is a neurodegenerative disease that devastatingly affects people's lives. Numerous research studies have shown that peroxynitrite (ONOO-) plays a pivotal role in the pathogenesis of PD. However, a suitable tool that could qui
Autor:
Mui Hoon Nai, Hoang-Dai Tran, Huck-Hui Ng, Chwee Teck Lim, Kah-Leong Lim, Haidun Yan, Koji Itahana, Menglan Zhang, Stephanie Wai Lin Lim, Qiang Yuan, Yoko Itahana, Giuseppe D'Agostino, Yong-hui Jiang, Alfred Xuyang Sun, Eng-King Tan, Danlei Wang, Hidayat Lokman, Owen J. L. Rackham, Weonjin Yu, Stuart A. Cook, Grace Lim, Ya Yin Chang, Masahiro Fukuda, Hyunsoo Shawn Je, Jiong Tang
Publikováno v:
Science. 366:1486-1492
Hyperexcitable neurons in brain organoids Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing f
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Autor:
Kah-Leong Lim, Monica Schenone, Jacqueline S. Garcia, Eunice S. Wang, Yingtian Xie, Henry W. Long, Eric S. Winer, Vivian J. Bardwell, R. C. Lindsley, Lukasz P. Gondek, Eva Johanna Schaefer, Marlise R. Luskin, Clifford A. Meyer, Richard Stone, Rahul S. Vedula, Annie Apffel, Martin Carroll, Emmalee R. Adelman, Murdock Hm, Steven A. Carr, Paloma Cejas, Iman Fares, Mario Figueroa, Huan Wang, Christopher J. Gibson, Gearhart
SummaryBCOR and its paralog BCORL1 encode subunits of the Polycomb repressive complex 1.1 (PRC1.1) and are recurrently mutated in myeloid malignancies. We show that leukemia-associated BCOR/BCORL1 mutations unlink the PRC1.1 RING-PCGF enzymatic core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fecef0e63b276ce52721deb286ccafe
https://doi.org/10.1101/2021.03.08.433705
https://doi.org/10.1101/2021.03.08.433705
Autor:
Tong Zhou, Naidi Yang, Lin Li, Qiong Wu, Kah-Leong Lim, Wei Huang, Yaqi Ding, Jiajia Xu, Qi Wang, Chenqi Xin, Ma Bo, Chengwu Zhang, Xiaomei Lu, Deqin Kong, Hang Zhang
Publikováno v:
NeuroMolecular Medicine. 22:56-67
Parkinson's disease (PD), the most common neurodegenerative movement disorder, is characterized by the progressive loss of dopaminergic neurons in substantia nigra. The underlying mechanisms of PD pathogenesis have not been fully illustrated and curr
Autor:
Siu Kwan Sze, Xavier Gallart-Palau, Aida Serra, Hee Hwa Ho, James P. Tam, Grace Lim, Jung Eun Park, Kah-Leong Lim
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:2396-2409
Objective— Vascular endothelial dysfunction is a key component of several major human diseases, but the molecular basis of this complex disorder has been difficult to determine in vivo. Previous attempts to identify key mediators of vascular endoth
Publikováno v:
Parkinson's Disease, Vol 2018 (2018)
Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra. The precise mechanism underlying pathogenesis of PD is not fully understood, but it has
Autor:
John Thundyil, Aaron S. C. Foo, Geraldine W.Y. Goh, Liting Hang, Kah-Leong Lim, Huey Ching Choong, Kong-Peng Lam, Shengli Xu, Ziyin Wang
Publikováno v:
Neurobiology of Disease, Vol 161, Iss, Pp 105560-(2021)
Emerging studies implicate energy dysregulation as an underlying trigger for Parkinson's disease (PD), suggesting that a better understanding of the molecular pathways governing energy homeostasis could help elucidate therapeutic targets for the dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4297372e7d776455194ef70f69ffb7c8
https://hdl.handle.net/10356/160637
https://hdl.handle.net/10356/160637
Autor:
Christopher G. Sobey, Shenpeng R. Zhang, Kah-Leong Lim, Hyun Ah Kim, Mitchell K.P. Lai, Michael De Silva, Christopher Chen, Thiruma V. Arumugam, David Y. Fann, Sharmelee Selvaraji, Grant R Drummond, Dong-Gyu Jo, Deron R. Herr, Sang-Ha Baik, Luting Poh
Publikováno v:
Aging (Albany NY)
Vascular dementia (VaD) is a progressive cognitive impairment of vascular etiology. VaD is characterized by cerebral hypoperfusion, increased blood-brain barrier permeability and white matter lesions. An increased burden of VaD is expected in rapidly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5327bfc01899f7409615f5f33c4eb92
https://hdl.handle.net/10356/153726
https://hdl.handle.net/10356/153726