Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Jian'an Luan"'
Autor:
Richard A. Jensen, Denis Rybin, Jaakko Tuomilehto, Reedik Mägi, Inga Prokopenko, Jeffrey R. O'Connell, Marcus E. Kleber, Han Chen, Geoffrey A. Walford, Allan Linnenberg, Anke Tönjes, Francis S. Collins, Sonsoles Morcillo, Gemma Rojo-Martínez, Kenneth Rice, Jose C. Florez, Leif Groop, Manuel Serrano-Ríos, Josée Dupuis, Alisa K. Manning, Peter Kovacs, Torben Jørgensen, Graciela E. Delgado, Alena Stančáková, Hans-Ulrich Häring, Claudia Langenberg, Joshua P. Lewis, Norbert Stefan, Markku Laakso, Torben Hansen, Bruce M. Psaty, Jian'an Luan, Michael Stumvoll, Mark O. Goodarzi, Robert A. Scott, Oluf Pedersen, Ching-Ti Liu, Michael N. Weedon, Michael Boehnke, Ulf Smith, David S. Siscovick, Aaron Leong, Weijia Xie, James B. Meigs, Claes Landenvall, Anne U. Jackson, Joseph M. Zmuda, Mary L. Biggs, Jerome I. Rotter, Federico Soriguer, Winfried März, Zhongyang Zhang, May E. Montasser, Arturo Corbatón-Anchuelo, J M Gómez-Zumaquero, Günther Silbernagel, Kristine Færch, Karen L. Mohlke, Heikki A. Koistinen, Yii-Der Ida Chen, Jaeyoung Hong, Gracia María Martín-Núñez, María Teresa Martínez-Larrad, Emil V. R. Appel, Niels Grarup, Harald Staiger, Johanna Kuusisto, Lars Lind, Nicholas J. Wareham, Andreas Fritsche, Stefan Gustafsson, Andrew P. Morris, Richard N. Bergman, Mark Walker, Cecilia M. Lindgren, Erik Ingelsson, Jorge R. Kizer, Timothy M. Frayling, Fausto Machicao
Publikováno v:
Diabetes
Walford, G A, Gustafsson, S, Rybin, D, Stančáková, A, Chen, H, Liu, C-T, Hong, J, Jensen, R A, Rice, K, Morris, A P, Mägi, R, Tönjes, A, Prokopenko, I, Kleber, M E, Delgado, G, Silbernagel, G, Jackson, A U, Appel, E V, Grarup, N, Lewis, J P, Montasser, M E, Landenvall, C, Staiger, H, Luan, J, Frayling, T M, Weedon, M N, Xie, W, Morcillo, S, Martínez-Larrad, M T, Biggs, M L, Ida Chen, Y-D, Corbaton-Anchuelo, A, Færch, K, Zumaquero, J M, Goodarzi, M O, Kizer, J, Koistinen, H A, Leong, A, Lind, L, Lindgren, C, Machicao, F, Manning, A K, Martín-Núñez, G M, Rojo-Martínez, G, Rotter, J I, Siscovick, D S, Zmuda, J M, Zhang, Z, Serrano-Rios, M, Smith, U, Soriguer, F, Hansen, T, Jørgensen, T J, Linnenberg, A, Pedersen, O, Walker, M, Langenberg, C, Scott, R A, Wareham, N J, Fritsche, A, Häring, H-U, Stefan, N, Groop, L, O'Connell, J R, Boehnke, M, Bergman, R N, Collins, F S, Mohlke, K L, Tuomilehto, J, März, W, Kovacs, P, Stumvoll, M, Psaty, B M, Kuusisto, J, Laakso, M, Meigs, J B, Dupuis, J, Ingelsson, E & Florez, J C 2016, ' Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci ', Diabetes, vol. 65, no. 10, pp. 3200-3211 . https://doi.org/10.2337/db16-0199
DIABETES
Walford, G A, Gustafsson, S, Rybin, D, Stančáková, A, Chen, H, Liu, C-T, Hong, J, Jensen, R A, Rice, K, Morris, A P, Mägi, R, Tönjes, A, Prokopenko, I, Kleber, M E, Delgado, G, Silbernagel, G, Jackson, A U, Appel, E V, Grarup, N, Lewis, J P, Montasser, M E, Landenvall, C, Staiger, H, Luan, J, Frayling, T M, Weedon, M N, Xie, W, Morcillo, S, Martínez-Larrad, M T, Biggs, M L, Ida Chen, Y-D, Corbaton-Anchuelo, A, Færch, K, Zumaquero, J M, Goodarzi, M O, Kizer, J, Koistinen, H A, Leong, A, Lind, L, Lindgren, C, Machicao, F, Manning, A K, Martín-Núñez, G M, Rojo-Martínez, G, Rotter, J I, Siscovick, D S, Zmuda, J M, Zhang, Z, Serrano-Rios, M, Smith, U, Soriguer, F, Hansen, T, Jørgensen, T J, Linnenberg, A, Pedersen, O, Walker, M, Langenberg, C, Scott, R A, Wareham, N J, Fritsche, A, Häring, H-U, Stefan, N, Groop, L, O'Connell, J R, Boehnke, M, Bergman, R N, Collins, F S, Mohlke, K L, Tuomilehto, J, März, W, Kovacs, P, Stumvoll, M, Psaty, B M, Kuusisto, J, Laakso, M, Meigs, J B, Dupuis, J, Ingelsson, E & Florez, J C 2016, ' Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci ', Diabetes, vol. 65, no. 10, pp. 3200-3211 . https://doi.org/10.2337/db16-0199
DIABETES
Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb835e572112710c128ad103623be68
Autor:
Yvonne T. van der Schouw, Eva Ardanaz, Ju-Sheng Zheng, Adam S. Butterworth, Maik Pietzner, Guy Fagherazzi, María José Sánchez, Rudolf Kaaks, Anne Tjønneland, Anja Olsen, Elio Riboli, Elisabete Weiderpass, Peter M. Nilsson, Luca A. Lotta, Thomas E. Gundersen, Olov Rolandsson, Claudia Langenberg, Nasser Laouali, Nita G. Forouhi, Pilar Amiano, Núria Sala, Kim Overvad, Sabina Sieri, Fulvio Ricceri, John Danesh, Jian'an Luan, Domenico Palli, Francesca Mancini, Annemieke M.W. Spijkerman, Rosario Tumino, Matthias B. Schulze, Eleni Sofianopoulou, María Dolores Chirlaque, N. Charlotte Onland-Moret, Eleanor Wheeler, Isobel D. Stewart, Paul W. Franks, Stephen J. Sharp, Salvatore Panico, Fumiaki Imamura, Nicholas J. Wareham, Felix R. Day
Publikováno v:
Diabetes Care
Zheng, J-S, Luan, J, Sofianopoulou, E, Imamura, F, Stewart, I D, Day, F R, Pietzner, M, Wheeler, E, Lotta, L A, Gundersen, T E, Amiano, P, Ardanaz, E, Chirlaque, M-D, Fagherazzi, G, Franks, P W, Kaaks, R, Laouali, N, Mancini, F R, Nilsson, P M, Onland-Moret, N C, Olsen, A, Overvad, K, Panico, S, Palli, D, Ricceri, F, Rolandsson, O, Spijkerman, A M W, Sánchez, M-J, Schulze, M B, Sala, N, Sieri, S, Tjønneland, A, Tumino, R, van der Schouw, Y T, Weiderpass, E, Riboli, E, Danesh, J, Butterworth, A S, Sharp, S J, Langenberg, C, Forouhi, N G & Wareham, N J 2021, ' Plasma Vitamin C and Type 2 Diabetes : Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations ', Diabetes Care, vol. 44, no. 1, pp. 98-106 . https://doi.org/10.2337/dc20-1328
Zheng, J-S, Luan, J, Sofianopoulou, E, Imamura, F, Stewart, I D, Day, F R, Pietzner, M, Wheeler, E, Lotta, L A, Gundersen, T E, Amiano, P, Ardanaz, E, Chirlaque, M-D, Fagherazzi, G, Franks, P W, Kaaks, R, Laouali, N, Mancini, F R, Nilsson, P M, Onland-Moret, N C, Olsen, A, Overvad, K, Panico, S, Palli, D, Ricceri, F, Rolandsson, O, Spijkerman, A M W, Sánchez, M-J, Schulze, M B, Sala, N, Sieri, S, Tjønneland, A, Tumino, R, van der Schouw, Y T, Weiderpass, E, Riboli, E, Danesh, J, Butterworth, A S, Sharp, S J, Langenberg, C, Forouhi, N G & Wareham, N J 2021, ' Plasma Vitamin C and Type 2 Diabetes : Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations ', Diabetes Care, vol. 44, no. 1, pp. 98-106 . https://doi.org/10.2337/dc20-1328
OBJECTIVE Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabet
Autor:
Tove Fall, Anubha Mahajan, Dmitry Shungin, B. Balkau, Gerjan Navis, A. Metspalu, Anneli Pouta, Andrew A. Hicks, Ilja M. Nolte, Ian Ford, Aroon D. Hingorani, Stefan R Bornstein, Anuj Goel, Rona J. Strawbridge, Niek Verweij, Sarah H. Wild, Patricia B. Munroe, T.B. Harris, Jaana Lindström, Johnson Pcd., Nita G. Forouhi, Pierre Meneton, Patricia A. Peyser, Sarin A-P., Andrea Ganna, Timothy M. Frayling, Patrik K. E. Magnusson, Joanne M. Meyer, Yongmei Liu, Jeanette M. Stafford, Christian Herder, L Zudina, Maria G. Stathopoulou, May E. Montasser, Nicholas D. Hastie, Inês Barroso, Schwarz Peh., James B. Meigs, Perttu Salo, George Davey Smith, Gonneke Willemsen, Christopher J. Groves, Erik P A Van Iperen, M. A. Province, Veikko Salomaa, Naveed Sattar, Serena Sanna, Maria Dimitriou, Joop Jukema, Ulrika Krus, Albert V. Smith, Markku Laakso, James F. Wilson, George Nicholson, Loic Yengo, Tatijana Zemunik, Per Eriksson, Harold Snieder, Peter P. Pramstaller, Claudia Langenberg, R. Rauramaa, Alan R. Shuldiner, Pau Navarro, Veronique Vitart, Ross M. Fraser, Aaron Isaacs, C. Lecoeur, Jesper R. Gådin, Jackie F. Price, Letizia Marullo, L.F. Bielak, Sirkka Keinänen-Kiukaanniemi, Amélie Bonnefond, Michael Stumvoll, Alessia Faggian, Anke Tönjes, Tomohiro Tanaka, Wieland Kiess, Harry Campbell, Josée Dupuis, David Altshuler, João Fadista, Winfried März, G K Hovingh, Thomas Illig, Toby Johnson, H Grallert, Kari Stefansson, Reedik Mägi, Palmer Cna., de Geus Ejcn., Martina Müller-Nurasyid, Karen Kapur, Philippe Froguel, Dorret I. Boomsma, Anders Franco-Cereceda, Marcus E. Kleber, Boehnke M, Olga D. Carlson, Ozren Polasek, Andrew P. Morris, Alex S. F. Doney, Najaf Amin, Sara M. Willems, Vilmundur Gudnason, Jose C. Florez, Jeffery R. O'Connell, Nancy L. Pedersen, T. Saaristo, Wolffenbuttel Bhr., M. I. J. Uusitupa, Longda Jiang, Iva Miljkovic, James S. Pankow, Caroline Hayward, Hugh Watkins, Vasiliki Lagou, Johanna Kuusisto, Jaakko Tuomilehto, Alan F. Wright, Josephine M. Egan, Perry Jrb., C M van Duijn, Valeriya Lyssenko, Leif Groop, Stefania Bandinelli, Nigel W. Rayner, Tõnu Esko, Stela McLachlan, Momoko Horikoshi, Eric Boerwinkle, Rick Jansen, Richard N. Bergman, Gudmar Thorleifsson, Lyle J. Palmer, Vilmantas Giedraitis, Peter Kovacs, Nicholas J. Wareham, Luigi Ferrucci, N J Timpson, D Rybin, Anne U. Jackson, Tiinamaija Tuomi, Gonçalo R. Abecasis, Harst Pvd., Meena Kumari, Albert Hofman, Chiara Scapoli, Evelin Mihailov, Josine L. Min, Anders Hamsten, Hottenga J-J., Loos Rjf., Lars Lind, Ulf de Faire, Jaakko Kaprio, Guo Li, Beate St Pourcain, C Gieger, Amanda J. Bennett, Anna Ulrich, Nabila Bouatia-Naji, Satu Männistö, Antigone S. Dimas, Jarvelin M-R., Günther Silbernagel, F Karpe, A. Körner, David S. Siscovick, M Blüher, Rebecca J. Webster, Erik Ingelsson, Susan Campbell, Mika Kivimäki, Laura J. Rasmussen-Torvik, Heikki A. Koistinen, Sophie Visvikis-Siest, Bernhard O. Boehm, Inga Prokopenko, Ping An, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Kardia Slr., Richa Saxena, Igor Rudan, Richard M. Watanabe, Jian'an Luan, Marika Kaakinen, Shin S-Y., George Dedoussis, Panagiotis Deloukas, Mark I. McCarthy, Barbara Thorand, B.W.J.H. Penninx, Peter Vollenweider, Paul W. Franks, Leena Kinnunen, Markus Perola, Yvonne Boettcher, Timo A. Lakka, Nicole Soranzo, Stavroula Kanoni, Bakker Sjl., Winkelmann Br
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature Communications, 12(1):24, 1-18. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 12(1):24. Nature Publishing Group UK
Lagou, V, Mägi, R, Hottenga, J J, Jansen, R, Min, J L, Willemsen, G, De Geus, E J C N, Penninx, B W, Boomsma, D I, Barroso, I, Morris, A P, Prokopenko, I & MAGIC Collaboration 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24, pp. 1-18 . https://doi.org/10.1038/s41467-020-19366-9
Min, J L, St Pourcain, M U B, Timpson, N J, Davey Smith, G, Prokopenko, I & et al. 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, 24 . https://doi.org/10.1038/s41467-020-19366-9
2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-021-21276-3
Nature communications, vol. 12, no. 1, pp. 24
Nature Communications, 12(1). NATURE RESEARCH
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature Communications, 12(1):24, 1-18. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 12(1):24. Nature Publishing Group UK
Lagou, V, Mägi, R, Hottenga, J J, Jansen, R, Min, J L, Willemsen, G, De Geus, E J C N, Penninx, B W, Boomsma, D I, Barroso, I, Morris, A P, Prokopenko, I & MAGIC Collaboration 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24, pp. 1-18 . https://doi.org/10.1038/s41467-020-19366-9
Min, J L, St Pourcain, M U B, Timpson, N J, Davey Smith, G, Prokopenko, I & et al. 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, 24 . https://doi.org/10.1038/s41467-020-19366-9
2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-021-21276-3
Nature communications, vol. 12, no. 1, pp. 24
Nature Communications, 12(1). NATURE RESEARCH
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5783e9d2579548e3deb52d1bbdf19db
https://hal.univ-lorraine.fr/hal-03105716
https://hal.univ-lorraine.fr/hal-03105716
Autor:
Alison D. Murray, Anna L. Guyatt, Jing Hua Zhao, Eugene R. Bleecker, Matthias Wielscher, Frank Dudbridge, Martin D. Tobin, Veronique Vitart, Ida Surakka, Nadia N. Hansel, Ozren Polasek, Caroline Hayward, David P. Strachan, Per Bakke, Stefan Karrasch, Anubha Mahajan, James F. Wilson, Shona M. Kerr, Ruth Tal-Singer, James D. Crapo, Victoria E. Jackson, Jonathan Marten, Olli T. Raitakari, María Soler Artigas, Medea Imboden, Sungho Won, Beate Stubbe, Ulf Gyllensten, George R. Washko, Eleftheria Zeggini, David A. Lynch, Brian D. Hobbs, Matthew Moll, Mika Kähönen, Rajesh Rawal, Guy Brusselle, Ma'en Obeidat, Nicholas J. Wareham, Claudia Langenberg, Nicole Probst-Hensch, Peter K. Joshi, Blair H. Smith, Stefan Weiss, Woo Jin Kim, Kathleen C. Barnes, Sarah E. Harris, David J. Porteous, Stefan Enroth, Ian P. Hall, Alan L. James, Sina A. Gharib, Paul R. H. J. Timmers, Xingnan Li, Louise V. Wain, John E. Hokanson, Holger Schulz, Ralf Ewert, Ani Manichaikul, Lies Lahousse, Georg Homuth, R. Graham Barr, Scott T. Weiss, Phuwanat Sakornsakolpat, Sara R.A. Wijnant, Edwin K. Silverman, Christian Gieger, Jennie Hui, Andrew P. Morris, James P. Cook, Michael J. McGeachie, Dawn L. DeMeo, Nick Shrine, Traci M. Bartz, Amund Gulsvik, Deborah A. Meyers, Katherine A. Kentistou, Igor Rudan, Jian'an Luan, Ian J. Deary, Catherine John, Michael H. Cho, Lars Lind, Marjo-Riitta Järvelin, Ah Ra Do, Terho Lehtimäki, Stephen S. Rich, Bruce M. Psaty
Publikováno v:
The Lancet. Respiratory Medicine
Moll, M, Sakornsakolpat, P, Shrine, N, Hobbs, B D, DeMeo, D L, John, C, Guyatt, A L, McGeachie, M J, Gharib, S A, Obeidat, M, Lahousse, L, Wijnant, S R A, Brusselle, G, Meyers, D A, Bleecker, E R, Li, X, Tal-Singer, R, Manichaikul, A, Rich, S S, Won, S, Kim, W J, Do, A R, Washko, G R, Barr, R G, Psaty, B M, Bartz, T M, Hansel, N N, Barnes, K, Hokanson, J E, Crapo, J D, Lynch, D, Bakke, P, Gulsvik, A, Hall, I P, Wain, L, Soler Artigas, M, Jackson, V E, Strachan, D P, Hui, J, James, A L, Kerr, S M, Polasek, O, Vitart, V, Marten, J, Rudan, I, Kähönen, M, Surakka, I, Gieger, C, Karrasch, S, Rawal, R, Schulz, H, Deary, I J, Harris, S E, Enroth, S, Gyllensten, U, Imboden, M, Probst-Hensch, N M, Lehtimäki, T, Raitakari, O T, Langenberg, C, Luan, J, Wareham, N, Zhao, J H, Hayward, C, Murray, A, Porteous, D J, Smith, B H, Jarvelin, M R, Wielscher, M, Joshi, P K, Kentistou, K A, Timmers, P RHJ, Wilson, J F, Cook, J P, Lind, L, Mahajan, A, Morris, A P, Ewert, R, Homuth, G, Stubbe, B, Weiss, S, Zeggini, E, Weiss, S T, Silverman, E K, Dudbridge, F, Tobin, M D & Cho, M H 2020, ' Chronic obstructive pulmonary disease and related phenotypes : polygenic risk scores in population-based and case-control cohorts ', The Lancet Respiratory Medicine, vol. 8, no. 7, pp. 696-708 . https://doi.org/10.1016/S2213-2600(20)30101-6
LANCET RESPIRATORY MEDICINE
Lancet Resp. Med. 8, 696-708 (2020)
The Lancet Respiratory Medicine, 8(7), 696-708. Elsevier Ltd.
Moll, M, Sakornsakolpat, P, Shrine, N, Hobbs, B D, DeMeo, D L, John, C, Guyatt, A L, McGeachie, M J, Gharib, S A, Obeidat, M, Lahousse, L, Wijnant, S R A, Brusselle, G, Meyers, D A, Bleecker, E R, Li, X, Tal-Singer, R, Manichaikul, A, Rich, S S, Won, S, Kim, W J, Do, A R, Washko, G R, Barr, R G, Psaty, B M, Bartz, T M, Hansel, N N, Barnes, K, Hokanson, J E, Crapo, J D, Lynch, D, Bakke, P, Gulsvik, A, Hall, I P, Wain, L, Soler Artigas, M, Jackson, V E, Strachan, D P, Hui, J, James, A L, Kerr, S M, Polasek, O, Vitart, V, Marten, J, Rudan, I, Kähönen, M, Surakka, I, Gieger, C, Karrasch, S, Rawal, R, Schulz, H, Deary, I J, Harris, S E, Enroth, S, Gyllensten, U, Imboden, M, Probst-Hensch, N M, Lehtimäki, T, Raitakari, O T, Langenberg, C, Luan, J, Wareham, N, Zhao, J H, Hayward, C, Murray, A, Porteous, D J, Smith, B H, Jarvelin, M R, Wielscher, M, Joshi, P K, Kentistou, K A, Timmers, P RHJ, Wilson, J F, Cook, J P, Lind, L, Mahajan, A, Morris, A P, Ewert, R, Homuth, G, Stubbe, B, Weiss, S, Zeggini, E, Weiss, S T, Silverman, E K, Dudbridge, F, Tobin, M D & Cho, M H 2020, ' Chronic obstructive pulmonary disease and related phenotypes : polygenic risk scores in population-based and case-control cohorts ', The Lancet Respiratory Medicine, vol. 8, no. 7, pp. 696-708 . https://doi.org/10.1016/S2213-2600(20)30101-6
LANCET RESPIRATORY MEDICINE
Lancet Resp. Med. 8, 696-708 (2020)
The Lancet Respiratory Medicine, 8(7), 696-708. Elsevier Ltd.
Background: Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants would predict COP
Autor:
Svati H. Shah, Olle Melander, Neneh Sallah, Quinn S. Wells, Jerome I. Rotter, Faye Zhao, Charlotte Andersson, Guðmundur Thorgeirsson, Ghazaleh Fatemifar, Alex S. F. Doney, Michael E. Dunn, David E. Lanfear, Ian Ford, Eric Boersma, Sonia Shah, Christopher Newton-Cheh, Douglas L. Mann, Niek Verweij, Carolina Roselli, Laura M. Yerges-Armstrong, Jian Yang, Christian Torp-Pedersen, Veikko Salomaa, Mary L. Biggs, Alaa Shalaby, Christoph Nowak, Stefan Gross, Patrick T. Ellinor, Mari Liis Tammesoo, Diane T. Smelser, Peter M. Visscher, Hans L. Hillege, Ruth C. Lovering, Honghuang Lin, Colin N. A. Palmer, Louis Philippe Lemieux Perreault, Jeffrey Brandimarto, Uwe Völker, Perttu Salo, Andrea Koekemoer, Rebecca Gutmann, Åsa K. Hedman, Nilesh J. Samani, Heming Xing, Faiez Zannad, Jaison Jacob, Harry Hemingway, Michael R. Brown, Franco Giulianini, Anubha Mahajan, Xing Chen, Alexander Niessner, Peter Almgren, Daniel I. Swerdlow, Gunnar Engström, Lars Lind, Tõnu Esko, Tomasz Czuba, Anna Helgadottir, Harvey D. White, David J. Stott, Johan Ärnlöv, Lars Køber, Chim C. Lang, Krishna G. Aragam, Kent D. Taylor, Anders Mälarstig, Frederick K. Kamanu, Kenneth B. Margulies, Michelle L. O'Donoghue, Andrew D. Morris, Sahar Ghasemi, J. Wouter Jukema, Jessica van Setten, Abbas Dehghan, Guillaume Paré, Luca A. Lotta, Giorgio E. M. Melloni, Albert Henry, Bruce M. Psaty, Paul M. Ridker, David J. Carey, Marie-Pierre Dubé, John S. Gottdiener, Xiaosong Wang, Per H. Svensson, Xu Chen, Patrik K. E. Magnusson, Claudia Langenberg, Alexander Teumer, Vilmantas Giedraitis, Simon de Denus, Michael W. Nagle, Marcus Dörr, Thomas P. Cappola, André G. Uitterlinden, Michael Morley, Eliana Portilla-Fernandez, J. Gustav Smith, Abirami Veluchamy, Peter Weeke, Ify R. Mordi, Unnur Thorsteinsdottir, Naveed Sattar, Folkert W. Asselbergs, Daniel I. Chasman, Daníel F. Guðbjartsson, Jonathan H. Chung, Marcus E. Kleber, Raul Weiss, Christopher P. Nelson, Spiros Denaxas, Bing Yu, Simon P. R. Romaine, Nicholas A Marston, Anjali T. Owens, Cecilia M. Lindgren, John J.V. McMurray, Joshua D. Backman, Michael V. Holmes, Stella Trompet, Hilma Holm, Kerri L. Wiggins, Jian'an Luan, Stephan B. Felix, Yifan Yang, Jemma B. Wilk, Maryam Kavousi, Markus Perola, Christian T. Ruff, Jean-Claude Tardif, G Sveinbjörnsson, Samuel C. Dudley, Nicholas J. Wareham, Teemu J. Niiranen, Andrew P. Morris, Danny Tuckwell, Maris Teder-Laving, R. Thomas Lumbers, James P. Cook, Géraldine Asselin, William A. Chutkow, Winfried März, Steven A. Lubitz, John G.F. Cleland, Bill Kraus, Ramachandran S. Vasan, Christopher M. Haggerty, Olympe Chazara, Chris Finan, Heather L. Bloom, Hans-Peter Brunner-La Rocca, Francoise Fougerousse, Kenneth Rice, Craig L. Hyde, Graciela E. Delgado, Mark Chaffin, Marc S. Sabatine, Alanna C. Morrison, Kay-Tee Khaw, Kari Stefansson, Felix Vaura, Barry London, Isabella Kardys, Aroon D. Hingorani, Hongsheng Gui, Steen Stender, René Fouodjio, Mohsen Ghanbari, Pim van der Harst, Nicholas L. Smith, Karoline Kuchenbaecker, Adriaan A. Voors, Benoit Tyl
Publikováno v:
ESC Heart Failure
ESC Heart Failure, Wiley, 2021, ⟨10.1002/ehf2.13517⟩
2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure . https://doi.org/10.1002/ehf2.13517
ESC Heart Failure. WILEY PERIODICALS, INC
ESC Heart Failure, 8(6), 5531-5541. WILEY PERIODICALS, INC
ESC heart failure, 8(6), 5531-5541. The Heart Failure Association of the European Society of Cardiology
ESC Heart Failure, 2021, ⟨10.1002/ehf2.13517⟩
Regeneron Genetics Center 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517
Esc heart failure, 8(6). John Wiley & Sons Inc.
Lumbers, R T, Shah, S, Lin, H, Czuba, T, Henry, A, Swerdlow, D I, Mälarstig, A, Andersson, C, Verweij, N, Holmes, M V, Ärnlöv, J, Svensson, P, Hemingway, H, Sallah, N, Almgren, P, Aragam, K G, Asselin, G, Backman, J D, Biggs, M L, Bloom, H L, Boersma, E, Brandimarto, J, Brown, M R, Brunner-La Rocca, H P, Carey, D J, Chaffin, M D, Chasman, D I, Chazara, O, Chen, X, Chen, X, Chung, J H, Chutkow, W, Cleland, J G F, Cook, J P, de Denus, S, Dehghan, A, Delgado, G E, Denaxas, S, Doney, A S, Dörr, M, Dudley, S C, Engström, G, Esko, T, Fatemifar, G, Felix, S B, Finan, C, Ford, I, Fougerousse, F, Fouodjio, R, Ghanbari, M, Ghasemi, S, Giedraitis, V, Giulianini, F, Gottdiener, J S, Gross, S, Guðbjartsson, D F, Gui, H, Gutmann, R, Haggerty, C M, van der Harst, P, Hedman, Å K, Helgadottir, A, Hillege, H, Hyde, C L, Jacob, J, Jukema, J W, Kamanu, F, Kardys, I, Kavousi, M, Khaw, K T, Kleber, M E, Køber, L, Koekemoer, A, Kraus, B, Kuchenbaecker, K, Langenberg, C, Lind, L, Lindgren, C M, London, B, Lotta, L A, Lovering, R C, Luan, J, Magnusson, P, Mahajan, A, Mann, D, Margulies, K B, Marston, N A, März, W, McMurray, J J V, Melander, O, Melloni, G, Mordi, I R, Morley, M P, Morris, A D, Morris, A P, Morrison, A C, Nagle, M W, Nelson, C P, Newton-Cheh, C, Niessner, A, Niiranen, T, Nowak, C, O'Donoghue, M L, Owens, A T, Palmer, C N A, Paré, G, Perola, M, Perreault, L P L, Portilla-Fernandez, E, Psaty, B M, Rice, K M, Ridker, P M, Romaine, S P R, Roselli, C, Rotter, J I, Ruff, C T, Sabatine, M S, Salo, P, Salomaa, V, van Setten, J, Shalaby, A A, Smelser, D T, Smith, N L, Stefansson, K, Stender, S, Stott, D J, Sveinbjörnsson, G, Tammesoo, M L, Tardif, J C, Taylor, K D, Teder-Laving, M, Teumer, A, Thorgeirsson, G, Thorsteinsdottir, U, Torp-Pedersen, C, Trompet, S, Tuckwell, D, Tyl, B, Uitterlinden, A G, Vaura, F, Veluchamy, A, Visscher, P M, Völker, U, Voors, A A, Wang, X, Wareham, N J, Weeke, P E, Weiss, R, White, H D, Wiggins, K L, Xing, H, Yang, J, Yang, Y, Yerges-Armstrong, L M, Yu, B, Zannad, F, Zhao, F, Regeneron Genetics Center, Wilk, J B, Holm, H, Sattar, N, Lubitz, S A, Lanfear, D E, Shah, S, Dunn, M E, Wells, Q S, Asselbergs, F W, Hingorani, A D, Dubé, M P, Samani, N J, Lang, C C, Cappola, T P, Ellinor, P T, Vasan, R S & Smith, J G 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC Heart Failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517
ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)
ESC Heart Failure, Wiley, 2021, ⟨10.1002/ehf2.13517⟩
2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure . https://doi.org/10.1002/ehf2.13517
ESC Heart Failure. WILEY PERIODICALS, INC
ESC Heart Failure, 8(6), 5531-5541. WILEY PERIODICALS, INC
ESC heart failure, 8(6), 5531-5541. The Heart Failure Association of the European Society of Cardiology
ESC Heart Failure, 2021, ⟨10.1002/ehf2.13517⟩
Regeneron Genetics Center 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517
Esc heart failure, 8(6). John Wiley & Sons Inc.
Lumbers, R T, Shah, S, Lin, H, Czuba, T, Henry, A, Swerdlow, D I, Mälarstig, A, Andersson, C, Verweij, N, Holmes, M V, Ärnlöv, J, Svensson, P, Hemingway, H, Sallah, N, Almgren, P, Aragam, K G, Asselin, G, Backman, J D, Biggs, M L, Bloom, H L, Boersma, E, Brandimarto, J, Brown, M R, Brunner-La Rocca, H P, Carey, D J, Chaffin, M D, Chasman, D I, Chazara, O, Chen, X, Chen, X, Chung, J H, Chutkow, W, Cleland, J G F, Cook, J P, de Denus, S, Dehghan, A, Delgado, G E, Denaxas, S, Doney, A S, Dörr, M, Dudley, S C, Engström, G, Esko, T, Fatemifar, G, Felix, S B, Finan, C, Ford, I, Fougerousse, F, Fouodjio, R, Ghanbari, M, Ghasemi, S, Giedraitis, V, Giulianini, F, Gottdiener, J S, Gross, S, Guðbjartsson, D F, Gui, H, Gutmann, R, Haggerty, C M, van der Harst, P, Hedman, Å K, Helgadottir, A, Hillege, H, Hyde, C L, Jacob, J, Jukema, J W, Kamanu, F, Kardys, I, Kavousi, M, Khaw, K T, Kleber, M E, Køber, L, Koekemoer, A, Kraus, B, Kuchenbaecker, K, Langenberg, C, Lind, L, Lindgren, C M, London, B, Lotta, L A, Lovering, R C, Luan, J, Magnusson, P, Mahajan, A, Mann, D, Margulies, K B, Marston, N A, März, W, McMurray, J J V, Melander, O, Melloni, G, Mordi, I R, Morley, M P, Morris, A D, Morris, A P, Morrison, A C, Nagle, M W, Nelson, C P, Newton-Cheh, C, Niessner, A, Niiranen, T, Nowak, C, O'Donoghue, M L, Owens, A T, Palmer, C N A, Paré, G, Perola, M, Perreault, L P L, Portilla-Fernandez, E, Psaty, B M, Rice, K M, Ridker, P M, Romaine, S P R, Roselli, C, Rotter, J I, Ruff, C T, Sabatine, M S, Salo, P, Salomaa, V, van Setten, J, Shalaby, A A, Smelser, D T, Smith, N L, Stefansson, K, Stender, S, Stott, D J, Sveinbjörnsson, G, Tammesoo, M L, Tardif, J C, Taylor, K D, Teder-Laving, M, Teumer, A, Thorgeirsson, G, Thorsteinsdottir, U, Torp-Pedersen, C, Trompet, S, Tuckwell, D, Tyl, B, Uitterlinden, A G, Vaura, F, Veluchamy, A, Visscher, P M, Völker, U, Voors, A A, Wang, X, Wareham, N J, Weeke, P E, Weiss, R, White, H D, Wiggins, K L, Xing, H, Yang, J, Yang, Y, Yerges-Armstrong, L M, Yu, B, Zannad, F, Zhao, F, Regeneron Genetics Center, Wilk, J B, Holm, H, Sattar, N, Lubitz, S A, Lanfear, D E, Shah, S, Dunn, M E, Wells, Q S, Asselbergs, F W, Hingorani, A D, Dubé, M P, Samani, N J, Lang, C C, Cappola, T P, Ellinor, P T, Vasan, R S & Smith, J G 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC Heart Failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517
ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)
Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure.Methods and results The consortium currently includes 51 studies from 11 countries, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc41b40a62755853d7042fbc1dfd58a0
https://hal.univ-lorraine.fr/hal-03357134
https://hal.univ-lorraine.fr/hal-03357134
Autor:
Albertine J. Oldehinkel, Wieland Kiess, Xueling Sim, Norihiro Kato, Philippe Froguel, Astrid van Hylckama Vlieg, Josée Dupuis, Nanette R. Lee, Symen Ligthart, Harry Campbell, Marta E. Alarcón-Riquelme, P. Eline Slagboom, Massimo Mangino, Tian Xie, Niek Verweij, James B. Meigs, Chaolong Wang, Michael Y. Tsai, Erik Ingelsson, Colin N. A. Palmer, Erik B. van den Akker, Fumihiko Matsuda, Rainer Rauramaa, Yi-Cheng Chang, Lars Lind, Stefan R. Bornstein, Mandy Vogel, Sven Bergmann, Ya X. Wang, Ching-Ti Liu, Annette Schürmann, Michael Boehnke, David J. Porteous, Kazuya Setoh, Qibin Qi, Ayse Demirkan, Francesco Cucca, Allan Linneberg, Claire J. Steves, Jun Liu, Leslie A. Lange, Noël P. Burtt, Diana Kuh, Cassandra N. Spracklen, Ken K. Ong, Charumathi Sabanayagam, Jost B. Jonas, Ele Ferrannini, Lawrence J. Beilin, Qing Duan, Blair H. Smith, Isobel D. Stewart, Alexander P. Reiner, Simon P. Mooijaart, Tim D. Spector, Paul W. Franks, E. Shyong Tai, Mark I. McCarthy, Anna L. Gloyn, D.I. Boomsma, Dennis Raven, Nicholas J. Timpson, Rona J. Strawbridge, George Dedoussis, Susan Redline, Jaeyoung Hong, Harald Grallert, Jagadish Vangipurapu, Rico Rueedi, Diane M. Becker, Marian Beekman, Claudia P. Cabrera, Johannes Waage, Jin Fang Chai, Yii-Der Ida Chen, Graciela E. Delgado, Thibaud S. Boutin, Yang Hai, Yoriko Heianza, Wei Zhao, Andres Metspalu, Tien Yin Wong, Mila Desi Anasanti, Inger Njølstad, Hans Bisgaard, Valeriya Lyssenko, Denis Rybin, Wanqing Wen, Torben Hansen, James F. Wilson, Sameline Grimsgaard, Annette Peters, Michele K. Evans, Damia Noce, Sarah C. Nelson, May E. Montasser, Nan Wang, Geltrude Mingrone, Gudny Eiriksdottir, Nicholas J. Wareham, Fouad Kandeel, Linda S. Adair, Kelvin Lam, Jaana Lindström, Eco J. C. de Geus, Debbie A Lawlor, Sara M. Willems, Xu Lin, Harold Snieder, Matt J. Neville, Naveed Sattar, Chelsea K. Raulerson, Paul M. Ridker, Jer-Yuarn Wu, Weihua Zhang, H. Janaka de Silva, Jana V. van Vliet-Ostaptchouk, Elena Tremoli, Toru Nabika, Jing Hua Zhao, Vilmundur Gudnason, Tao Huang, Robert C. Kaplan, Sohee Han, Mohammad Hadi Zafarmand, Aaron Leong, Yen-Feng Chiu, Kumaraswamy Naidu Chitrala, Ivana Kolcic, Franco Giulianini, Tao Wang, Lu Qi, Stephan J. L. Bakker, Laura J Corbin, Zoltán Kutalik, Bruna Gigante, Willa A. Hsueh, Peter J. van der Most, Tin Louie, Yujie Wang, Stella Trompet, Fernando Rivideneira, Yasumasa Ohyagi, Lynne E. Wagenknecht, Jerry L. Nadler, Michael Stumvoll, Mark O. Goodarzi, Sahoko Ichihara, Jeffrey R. O'Connell, Tomohiro Katsuya, Giorgio Pistis, Alice Stanton, Sirkka Keinänen-Kiukaanniemi, Momoko Horikoshi, Honglan Li, Tanja G. M. Vrijkotte, Caroline Hayward, Karen L. Mohlke, Carola Marzi, Girish N. Nadkarni, Laura J. Rasmussen-Torvik, Alain G. Bertoni, Andrew R. Wood, Annique Claringbould, Mi Yeong Hwang, Hugh Watkins, Heikki A. Koistinen, Mattias Frånberg, Jani Heikkinen, Elizabeth Selvin, Donald W. Bowden, Abbas Dehghan, Christian Fuchsberger, Audrey Y. Chu, Kent D. Taylor, Katherine A. Kentistou, Johanna Kuusisto, Jingyi Tan, Huaixing Li, Eric Boerwinkle, Catharina A. Hartman, Archie Campbell, Kari E. North, Oluf Pedersen, Sölve Elmståhl, Emil V. R. Appel, Chang-Hsun Hsieh, Dennis O. Mook-Kanamori, Rob M. van Dam, Pontiano Kaleebu, Corri Black, Jennifer A. Brody, Bengt Sennblad, Shaofeng Huo, M. Larissa Avilés-Santa, Ruth J. F. Loos, Patricia B. Munroe, Chien-Hsiun Chen, Liang Sun, Zorayr Arzumanyan, Rebecca Rohde, Yasuharu Tabara, Albert V. Smith, Betina H. Thuesen, Niels Grarup, Jorgen Engmann, Tatijana Zemunik, M. Arfan Ikram, Marit E. Jørgensen, Christian Herder, Ching-Yu Cheng, Serena Sanna, Damiano Baldassarre, Tarunveer S. Ahluwalia, Mark J. Caulfield, Anne Ndungu, Carl D. Langefeld, Lisa R. Yanek, Luigi Ferrucci, Ananda R. Wickremasinghe, Raymond Noordam, Trevor A. Mori, Tom Wilsgaard, Mika Kivimäki, Rita R. Kalyani, Alan B. Zonderman, Veronique Vitart, Patricia A. Peyser, Shuiqing Lai, Richa Saxena, Li-Ching Chang, Karin Leander, Wei Huang, Peter Vollenweider, Tanya M. Teslovich, Ying Wu, Shufa Du, Brian E. Cade, Patrik K. E. Magnusson, John C. Chambers, Stephen C. J. Parker, Tamar Sofer, Winfried März, Sharon L.R. Kardia, Peter K. Joshi, Neil R. Robertson, Anny H. Xiang, Fumihiko Takeuchi, N. Amin, Jouke-Jan Hottenga, Carol A. Wang, Stefan Gustafsson, Jung Ho Gong, Penny Gordon-Larsen, Yu-Tang Gao, Abhishek Nag, Gonneke Willemsen, Michael A. Province, Aliki-Eleni Farmaki, Segun Fatumo, Antje Körner, Pim van der Harst, Marie Loh, Kei Hang Katie Chan, Gonçalo R. Abecasis, Nicholette D. Palmer, Simin Liu, Ishminder K. Kooner, Javier Gayán, Arne Astrup, Laura J. Scott, Erwin P. Bottinger, Andrew Wong, Inga Prokopenko, Ping An, Markku Laakso, Matthias Blüher, Susan R. Heckbert, Thomas A. Buchanan, Tatsuaki Matsubara, Andrew P. Morris, Brian H. Chen, Kristi Läll, Teresa Tusie, Timo A. Lakka, Jie Yao, Michael Preuss, Teemu Kuulasmaa, Carlos Lorenzo, Stephen S. Rich, Marie Lauzon, Laura M. Raffield, Pankow S. James, Takahisa Kawaguchi, Kathleen A. Ryan, Wei Zheng, Igor Rudan, Thomas Sparsø, Hugoline G. de Haan, Sandosh Padmanabhan, Richard M. Watanabe, Alicia Huerta-Chagoya, Anette P. Gjesing, Andrew A. Hicks, Richard N. Bergman, Mitsuhiro Yokota, Heather M. Stringham, Bruce M. Psaty, Jian'an Luan, Anuj Goel, Eleanor Wheeler, Masahiro Nakatochi, Young-Jin Kim, Xiao-Ou Shu, Mickaël Canouil, Robert A. Scott, Marika Kaakinen, Mari Nelis, Adolfo Correa, Jaspal S. Kooner, Michiya Igase, Anubha Mahajan, Peter E. H. Schwarz, Craig E. Pennell, Claudia Schurmann, Xiaoran Chai, Ji Chen, Lori L. Bonnycastle, Peter S. Sever, Thorkild I. A. Sørensen, André G. Uitterlinden, Ilja M. Nolte, Gaëlle Marenne, Timothy M. Frayling, Bong-Jo Kim, Kerrin S. Small, Cecilia M. Lindgren, Bernhard O. Böhm, Shih-Yi Lin, Katharina E. Schraut, Cornelia M. van Duijn, Sanghoon Moon, Mark Walker, Chiea Chuen Khor, Ruifang Li-Gao, Qiuyin Cai, Neil Schneiderman, Ko Willems van Dijk, Ozren Polasek, W. Craig Johnson, Dermot F. Reilly, Inês Barroso, Anke Tönjes, Manjinder S. Sandhu, Wen B. Wei, Jose C. Florez, Lorraine Southam, Leif Groop, Lawrence F. Bielak, Peter Kovacs, Jianjun Liu, Jouko Saramies, Helen R. Warren, Man Li, Daniel I. Chasman, Eleftheria Zeggini, Xiaoshuai Zhang, Loic Yengo, Shi Jinxiu, Jirong Long, Xiuqing Guo, Meena Kumari, Leslie J. Raffel, Jill M. Norris, Henrik Vestergaard, Jing He, Peter P. Pramstaller, Diana van Heemst, Kevin Sandow, Marjo-Ritta Jarvelin, Carlos A. Aguilar-Salinas, Peitao Wu, Hortensia Moreno-Macías, Jerome I. Rotter, Kathryn Roll, Frits R. Rosendaal, Bernardo L. Horta, Heming Wang, Fernando Pires Hartwig, Richard A. Jensen, Matti Uusitupa, Rozenn N. Lemaitre, Paul R. H. J. Timmers, Timo Saaristo, Jaakko Tuomilehto, Reedik Mägi, Debashree Ray, J. Wouter Jukema, Claudia Langenberg, Marcus E. Kleber, Francis S. Collins, Klaus Bønnelykke, Lenore J. Launer, Arushi Varshney, Anders Hamsten
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, 2021, ⟨10.1038/s41588-021-00852-9⟩
Lifelines Cohort Study & Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC) 2021, ' The trans-ancestral genomic architecture of glycemic traits ', Nature Genetics, vol. 53, no. 6, pp. 840-860 . https://doi.org/10.1038/s41588-021-00852-9
Nature genetics, vol. 53, no. 6, pp. 840-860
Chen, J, Spracklen, C N, Marenne, G, Varshney, A, Corbin, L J, Luan, J, Willems, S M, Wu, Y, Zhang, X, Horikoshi, M, Boutin, T S, Magi, R, Waage, J, Li-Gao, R, Chan, K H K, Yao, J, Anasanti, M D, Chu, A Y, Claringbould, A, Heikkinen, J, Hong, J, Hottenga, J-J, Huo, S, Kaakinen, M A, Louie, T, Maerz, W, Moreno-Macias, H, Ndungu, A, Nelson, S C, Nolte, I M, North, K E, Appel, E V R, Liu, J, Sparso, T, Zhao, J-H, Astrup, A, Jørgensen, M E, Linneberg, A, Vestergaard, H, Bisgaard, H, Bønnelykke, K, Grarup, N, Hansen, T, Kovacs, P, Lind, L, Loos, R J F, Njølstad, I, Pedersen, O, Schwarz, P, Sorensen, T I A & Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC) 2021, ' The trans-ancestral genomic architecture of glycemic traits ', Nature Genetics, vol. 53, no. 6, pp. 840-860 . https://doi.org/10.1038/s41588-021-00852-9
Nature genetics
Nature Genetics, 53(6), 840-860. NATURE RESEARCH
Chen, J, Spracklen, C N, Marenne, G, Varshney, A, Corbin, L J, Hottenga, J, De Geus, E J C, Van Dam, R M, Boomsma, D I, Vrijkotte, T G M, Willemsen, G & MAGIC Investigators 2021, ' The trans-ancestral genomic architecture of glycemic traits ', Nature Genetics, vol. 53, no. 6, pp. 840-860 . https://doi.org/10.1038/s41588-021-00852-9
2021, ' The trans-ancestral genomic architecture of glycemic traits ', Nature Genetics, vol. 53 . https://doi.org/10.1038/s41588-021-00852-9
Nature Genetics, 53(6), 840-860. Nature Publishing Group
Nature genetics, 53(6), 840-860. Nature Publishing Group
Corbin, L J, Timpson, N J, Lawlor, D A, Barroso, I & et al. 2021, ' The Trans-Ancestral Genomic Architecture of Glycemic Traits ', Nature Genetics, vol. 53, no. 6, pp. 840-860 . https://doi.org/10.1038/s41588-021-00852-9
Nature Genetics, 53, 840-860. Nature Publishing Group
Nature Genetics, Nature Publishing Group, 2021, ⟨10.1038/s41588-021-00852-9⟩
Lifelines Cohort Study & Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC) 2021, ' The trans-ancestral genomic architecture of glycemic traits ', Nature Genetics, vol. 53, no. 6, pp. 840-860 . https://doi.org/10.1038/s41588-021-00852-9
Nature genetics, vol. 53, no. 6, pp. 840-860
Chen, J, Spracklen, C N, Marenne, G, Varshney, A, Corbin, L J, Luan, J, Willems, S M, Wu, Y, Zhang, X, Horikoshi, M, Boutin, T S, Magi, R, Waage, J, Li-Gao, R, Chan, K H K, Yao, J, Anasanti, M D, Chu, A Y, Claringbould, A, Heikkinen, J, Hong, J, Hottenga, J-J, Huo, S, Kaakinen, M A, Louie, T, Maerz, W, Moreno-Macias, H, Ndungu, A, Nelson, S C, Nolte, I M, North, K E, Appel, E V R, Liu, J, Sparso, T, Zhao, J-H, Astrup, A, Jørgensen, M E, Linneberg, A, Vestergaard, H, Bisgaard, H, Bønnelykke, K, Grarup, N, Hansen, T, Kovacs, P, Lind, L, Loos, R J F, Njølstad, I, Pedersen, O, Schwarz, P, Sorensen, T I A & Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC) 2021, ' The trans-ancestral genomic architecture of glycemic traits ', Nature Genetics, vol. 53, no. 6, pp. 840-860 . https://doi.org/10.1038/s41588-021-00852-9
Nature genetics
Nature Genetics, 53(6), 840-860. NATURE RESEARCH
Chen, J, Spracklen, C N, Marenne, G, Varshney, A, Corbin, L J, Hottenga, J, De Geus, E J C, Van Dam, R M, Boomsma, D I, Vrijkotte, T G M, Willemsen, G & MAGIC Investigators 2021, ' The trans-ancestral genomic architecture of glycemic traits ', Nature Genetics, vol. 53, no. 6, pp. 840-860 . https://doi.org/10.1038/s41588-021-00852-9
2021, ' The trans-ancestral genomic architecture of glycemic traits ', Nature Genetics, vol. 53 . https://doi.org/10.1038/s41588-021-00852-9
Nature Genetics, 53(6), 840-860. Nature Publishing Group
Nature genetics, 53(6), 840-860. Nature Publishing Group
Corbin, L J, Timpson, N J, Lawlor, D A, Barroso, I & et al. 2021, ' The Trans-Ancestral Genomic Architecture of Glycemic Traits ', Nature Genetics, vol. 53, no. 6, pp. 840-860 . https://doi.org/10.1038/s41588-021-00852-9
Nature Genetics, 53, 840-860. Nature Publishing Group
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies compris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd7b30b504793e1c50aff861c4059fa
http://hdl.handle.net/10044/1/98553
http://hdl.handle.net/10044/1/98553
Autor:
Diana Kuh, Aroon D. Hingorani, Maria Carolina Borges, Jian'an Luan, Tina Shah, John C. Chambers, Andrew Wong, Claudia Langenberg, Debbie A Lawlor, Juha Auvinen, Sylvain Sebert, N. Maneka G. De Silva, Weihua Zhang, Jorgen Engmann, Tom R. Gaunt, Marjo-Ritta Jarvelin, Xiaoshuai Zhang
Publikováno v:
Diabetes
De Silva, M, Borges, C, Hingorani, A, Engmann, J, Shah, T, Zhang, X, Luan, J, Langenberg, C, Wong, A, Kuh, D, Chambers, J C, Zhang, W, Jarvelin, M-R, Sebert, S, Auvinen, J & Gaunt, T & Lawlor, D 2019, ' Liver Function and Risk of Type 2 Diabetes : Bidirectional Mendelian Randomization Study ', Diabetes, vol. 68, no. 8, db181048, pp. 1681-1691 . https://doi.org/10.2337/db18-1048
De Silva, M, Borges, C, Hingorani, A, Engmann, J, Shah, T, Zhang, X, Luan, J, Langenberg, C, Wong, A, Kuh, D, Chambers, J C, Zhang, W, Jarvelin, M-R, Sebert, S, Auvinen, J & Gaunt, T & Lawlor, D 2019, ' Liver Function and Risk of Type 2 Diabetes : Bidirectional Mendelian Randomization Study ', Diabetes, vol. 68, no. 8, db181048, pp. 1681-1691 . https://doi.org/10.2337/db18-1048
Liver dysfunction and type 2 diabetes (T2D) are consistently associated. However, it is currently unknown whether liver dysfunction contributes to, results from, or is merely correlated with T2D due to confounding. We used Mendelian randomization to
Autor:
Phuwanat Sakornsakolpat, James F. Wilson, María Soler Artigas, Beate Stubbe, Nicholas J. Wareham, James D. Crapo, Victoria E. Jackson, Eleftheria Zeggini, Olga G. Troyanskaya, Medea Imboden, A. Mesut Erzurumluoglu, Adam S. Butterworth, Carl A. Melbourne, Ian Sayers, Lars Lind, Stefan Weiss, Margaret M. Parker, Timmers Prhj, Edwin K. Silverman, John C. Whittaker, Ian P. Hall, Ozren Polasek, Mika Kähönen, Katherine A. Fawcett, Anna Hansell, Liming Li, David J. Porteous, Louise V. Wain, Robert A. Scott, Richard Packer, Richard J. Allen, Robin G Walters, Anna L. Guyatt, Terho Lehtimäki, Nicole Probst-Hensch, Shona M. Kerr, Christian Gieger, Matthias Wielscher, Rajesh Rawal, Jing Hua Zhao, John E. Hokanson, Holger Schulz, Nicola F. Reeve, Claudia Langenberg, Ke Hao, Corry-Anke Brandsma, Megan L. Paynton, Vitart, Dmitry Prokopenko, Jennie Hui, Eugene R. Bleecker, Ma'en Obeidat, John Danesh, Ralf Ewert, Benjamin B. Sun, Frank Dudbridge, Jian Zhou, Brian D. Hobbs, Blair H. Smith, Don D. Sin, Dawn L. DeMeo, Joseph C. Maranville, Ida Surakka, Alison Catherine Murray, Nicholas Locantore, Katherine A. Kentistou, Terri H. Beaty, Igor Rudan, Kuang Lin, Amund Gulsvik, Ian J. Deary, Ruth Tal-Singer, Kijoung Song, David C. Nickle, Michael H. Cho, Jian'an Luan, Joshua D. Hoffman, Georg Homuth, Zhengming Chen, Dandi Qiao, Heiko Runz, Per Bakke, Chiara Batini, Caroline Hayward, Stefan Karrasch, Alan James, Andrew P. Morris, Prescott G. Woodruff, Laura M Yerges Armstrong, David Sparrow, Ulf Gyllensten, James P. Cook, Jonathan Marten, Olli T. Raitakari, Nick Shrine, Deborah A. Meyers, Tobin, Ruth Boxall, Marjo-Riitta Järvelin, David P. Strachan, Sarah E. Harris, Philippe Joubert, Stefan Enroth, Xingnan Li, van den Berge M, Anubha Mahajan, Yohan Bossé, Peter K. Joshi
Publikováno v:
Nature genetics
Nat. Genet. 51, 481-493 (2019)
Shrine, N R G, Guyatt, A, Erzurumluoglu, A M, Jackson, V E, Hobbs, B D, Melbourne, C, Batini, C, Fawcett, K A, Song, K, Sakornsakolpat, P, Li, X, Boxall, R, Reeve, N F, Obeidat, M, Zhao, J H, Wielscher, M, Weiss, S, Kentistou, K, Cook, J P, Sun, B B, Zhou, J, Hui, J, Karrasch, S, Imboden, M, Harris, S, Marten, J, Enroth, S, Kerr, S, Surakka, I, Vitart, V, Lehtimäki, T, Allen, R J, Bakke, P S, Beaty, T H, Bleecker, E R, Bossé, Y, Brandsma, C-A, Chen, Z, Crapo, J D, Danesh, J, Demeo, D L, Dudbridge, F, Ewert, R, Gieger, C, Gulsvik, A, Hansell, A L, Hao, K, Hoffman, J D, Hokanson, J E, Homuth, G, Joshi, P, Joubert, P, Langenberg, C, Li, X, Li, L, Lin, K, Lind, L, Locantore, N, Luan, J, Mahajan, A, Maranville, J C, Murray, A, Nickle, D C, Packer, R, Parker, M M, Paynton, M L, Porteous, D, Prokopenko, D, Qiao, D, Rawal, R, Runz, H, Sayers, I, Sin, D D, Smith, B H, Soler Artigas, M, Sparrow, D, Tal-Singer, R, Timmers, P RHJ, van den Berge, M, Woodruff, P G, Yerges-Armstrong, L M, Troyanskaya, O G, Raitakar, O, Kähönen, M, Polasek, O, Rudan, I, Deary, I, Probst-Hensch, N M, Schulz, H, James, A L, Wilson, J F, Stubbe, B, Zeggini, E, Jarvelin, M-R, Wareham, N, Silverman, E K, Hayward, C, Morris, A P, Butterworth, A S, Scott, R A, Walters, R G, Meyers, D A, Cho, M H, Strachan, D P, Hall, I P & Tobin, M D & Wain, L V 2019, ' New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, pp. 481–493 . https://doi.org/10.1038/s41588-018-0321-7
NATURE GENETICS
Understanding Society Scientific Group 2019, ' New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, no. 3, pp. 481-493 . https://doi.org/10.1038/s41588-018-0321-7
Nature Genetics, 51(3), 481-493. Nature Publishing Group
Nat. Genet. 51, 481-493 (2019)
Shrine, N R G, Guyatt, A, Erzurumluoglu, A M, Jackson, V E, Hobbs, B D, Melbourne, C, Batini, C, Fawcett, K A, Song, K, Sakornsakolpat, P, Li, X, Boxall, R, Reeve, N F, Obeidat, M, Zhao, J H, Wielscher, M, Weiss, S, Kentistou, K, Cook, J P, Sun, B B, Zhou, J, Hui, J, Karrasch, S, Imboden, M, Harris, S, Marten, J, Enroth, S, Kerr, S, Surakka, I, Vitart, V, Lehtimäki, T, Allen, R J, Bakke, P S, Beaty, T H, Bleecker, E R, Bossé, Y, Brandsma, C-A, Chen, Z, Crapo, J D, Danesh, J, Demeo, D L, Dudbridge, F, Ewert, R, Gieger, C, Gulsvik, A, Hansell, A L, Hao, K, Hoffman, J D, Hokanson, J E, Homuth, G, Joshi, P, Joubert, P, Langenberg, C, Li, X, Li, L, Lin, K, Lind, L, Locantore, N, Luan, J, Mahajan, A, Maranville, J C, Murray, A, Nickle, D C, Packer, R, Parker, M M, Paynton, M L, Porteous, D, Prokopenko, D, Qiao, D, Rawal, R, Runz, H, Sayers, I, Sin, D D, Smith, B H, Soler Artigas, M, Sparrow, D, Tal-Singer, R, Timmers, P RHJ, van den Berge, M, Woodruff, P G, Yerges-Armstrong, L M, Troyanskaya, O G, Raitakar, O, Kähönen, M, Polasek, O, Rudan, I, Deary, I, Probst-Hensch, N M, Schulz, H, James, A L, Wilson, J F, Stubbe, B, Zeggini, E, Jarvelin, M-R, Wareham, N, Silverman, E K, Hayward, C, Morris, A P, Butterworth, A S, Scott, R A, Walters, R G, Meyers, D A, Cho, M H, Strachan, D P, Hall, I P & Tobin, M D & Wain, L V 2019, ' New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, pp. 481–493 . https://doi.org/10.1038/s41588-018-0321-7
NATURE GENETICS
Understanding Society Scientific Group 2019, ' New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, no. 3, pp. 481-493 . https://doi.org/10.1038/s41588-018-0321-7
Nature Genetics, 51(3), 481-493. Nature Publishing Group
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which ar
Autor:
Panos Deloukas, Christina-Alexandra Schulz, Caren E. Smith, Lu Qi, Mary F. Feitosa, Melissa E. Garcia, Natalia Pervjakova, Denise K. Houston, Michael A. Province, Stavroula Kanoni, Torben Hansen, Jean Shin, Lynda M. Rose, Oscar H. Franco, Yongmei Liu, Trudy Voortman, Marie-Claude Vohl, Luigi Ferrucci, Chloé Sarnowski, Paul S. de Vries, Jose C. Florez, John C. Lieske, Louis Pérusse, Misa Graff, Jian'an Luan, Nicola M. McKeown, Felix R. Day, L. Adrienne Cupples, Qibin Qi, Frank J. A. van Rooij, Robert A. Scott, Josée Dupuis, Stephen S. Rich, Jorma Viikari, Tarunveer S. Ahluwalia, Leo-Pekka Lyytikäinen, Paul M. Ridker, Tomáš Paus, Stephen Turner, Harri Rissanen, Audrey Y. Chu, Albert Hofman, Olli T. Raitakari, Paul Knekt, Daniel I. Chasman, Nita G. Forouhi, Vera Mikkilä, Toshiko Tanaka, Mika Kähönen, George Dedoussis, Minjung Kho, Yun J. Sung, Anne E. Justice, Julius S. Ngwa, Ani Manichaikul, M. Carola Zillikens, Jordi Merino, Dena G. Hernandez, Rozenn N. Lemaitre, Tao Huang, Sharon L.R. Kardia, Jing Hua Zhao, Stefania Bandinelli, Veikko Salomaa, Arne Astrup, Wei Zhao, David S. Siscovick, John Blangero, Zdenka Pausova, Dabeeru C. Rao, Oluf Pedersen, Craig E. Pennell, Wendy H. Oddy, Jose M. Ordovas, Jessica C. Kiefte-de Jong, Marju Orho-Melander, Hassan S. Dashti, Satu Männistö, Tuomo Rankinen, Constantina Papoutsakis, Sherly X. Li, Antti Jula, Kari E. North, Thorkild I. A. Sørensen, André G. Uitterlinden, Alexis C. Frazier-Wood, Nicholas J. Wareham, Ulrika Ericson, Markus Perola, Ioanna P. Kalafati, Renée de Mutsert, Jinyan Huang, Ruifang Li-Gao, Claudia Langenberg, Mike A. Nalls, Olivia Li, Joanne E. Curran, Dennis O. Mook-Kanamori, Niina Eklund, Jerome I. Rotter, Angelo Tremblay, Claude Bouchard, Jennifer A. Smith, Terho Lehtimäki, Mary K. Wojczynski, Carol A. Wang
Publikováno v:
Molecular Psychiatry
Molecular Psychiatry, 24(12), 1920-1932. Nature Publishing Group
Molecular Psychiatry, 24(12), 1920-1932
Molecular Psychiatry, 24(12), 1920-1932. Nature Publishing Group
Molecular Psychiatry, 24(12), 1920-1932
Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrie
Autor:
Kamil Sicinski, B. Gwen Windham, Nathalie van der Velde, Luigi Ferrucci, Jian'an Luan, Fernando Rivadeneira, Thuy Vy Duong, Ryan Cvejkus, David A. Bennett, José A. Carnicero, Megan L. Grove, Stefan Walter, Cheryl L. Ackert-Bicknell, Joshua R. Lewis, Adam J. Santanasto, David Melzer, Aron S. Buchman, Janice L. Atkins, Garan Jones, Joanne M. Murabito, Shengjun Hong, Stefania Bandinelli, Michelle C. Odden, Leocadio Rodríguez-Mañas, Magnus Karlsson, Erika Kague, Najada Stringa, Francisco J. Garcia, Chia-Ling Kuo, Dominik Spira, Maria Nethander, André G. Uitterlinden, Claes Ohlsson, Jingyun Yang, Sahar Ghasemi, George A. Kuchel, Dan Mellström, Eric Boerwinkle, Pamela Herd, Lisette C. P. G. M. de Groot, Alexander Teumer, M. Carola Zillikens, Alison E. Fohner, Dan E. Arking, Douglas P. Kiel, Kathryn L. Lunetta, Claudia Langenberg, Toshiko Tanaka, David Karasik, Natasja M. van Schoor, Thomas Kocher, Luke C. Pilling, Lars Bertram, Bruce M. Psaty, Philip L. De Jager, Katerina Trajanoska, Martijn Huisman, Joseph M. Zmuda, Mary L. Biggs, Misa Graff, Qihua Tan, Ilja Demuth, Mary K. Wojczynski, Nicholas J. Wareham, Uwe Völker, Chloé Sarnowski
Publikováno v:
Nature Communications, 12(1)
Jones, G, Trajanoska, K, Santanasto, A J, Stringa, N, Kuo, C-L, Atkins, J L, Lewis, J R, Duong, T, Hong, S, Biggs, M L, Luan, J, Sarnowski, C, Lunetta, K L, Tanaka, T, Wojczynski, M K, Cvejkus, R, Nethander, M, Ghasemi, S, Yang, J, Zillikens, M C, Walter, S, Sicinski, K, Kague, E, Ackert-Bicknell, C L, Arking, D E, Windham, B G, Boerwinkle, E, Grove, M L, Graff, M, Spira, D, Demuth, I, van der Velde, N, de Groot, L C P G M, Psaty, B M, Odden, M C, Fohner, A E, Langenberg, C, Wareham, N J, Bandinelli, S, van Schoor, N M, Huisman, M, Tan, Q, Zmuda, J, Mellström, D, Karlsson, M, Bennett, D A, Buchman, A S, De Jager, P L, Uitterlinden, A G, Völker, U, Kocher, T, Teumer, A, Rodriguéz-Mañas, L, García, F J, Carnicero, J A, Herd, P, Bertram, L, Ohlsson, C, Murabito, J M, Melzer, D, Kuchel, G A, Ferrucci, L, Karasik, D, Rivadeneira, F, Kiel, D P & Pilling, L C 2021, ' Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women ', Nature Communications, vol. 12, no. 1, 654 . https://doi.org/10.1038/s41467-021-20918-w
Nature Communications
Nature Communications, 12(1):654. Nature Publishing Group
Nature Communications, 12(1):654
Nature communications, 12(1):654. Nature Publishing Group
Jones, G, Trajanoska, K, Santanasto, A J, Stringa, N, Kuo, C-L, Atkins, J L, Lewis, J R, Duong, T, Hong, S, Biggs, M L, Luan, J, Sarnowski, C, Lunetta, K L, Tanaka, T, Wojczynski, M K, Cvejkus, R, Nethander, M, Ghasemi, S, Yang, J, Zillikens, M C, Walter, S, Sicinski, K, Kague, E, Ackert-Bicknell, C L, Arking, D E, Windham, B G, Boerwinkle, E, Grove, M L, Graff, M, Spira, D, Demuth, I, van der Velde, N, de Groot, L C P G M, Psaty, B M, Odden, M C, Fohner, A E, Langenberg, C, Wareham, N J, Bandinelli, S, van Schoor, N M, Huisman, M, Tan, Q, Zmuda, J, Mellström, D, Karlsson, M, Bennett, D A, Buchman, A S, de Jager, P L, Uitterlinden, A G, Völker, U, Kocher, T, Teumer, A, Rodriguéz-Mañas, L, García, F J, Carnicero, J A, Herd, P, Bertram, L, Ohlsson, C, Murabito, J M, Melzer, D, Kuchel, G A, Ferrucci, L, Karasik, D, Rivadeneira, F, Kiel, D P & Pilling, L C 2021, ' Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women ', Nature Communications, vol. 12, no. 1, 654 . https://doi.org/10.1038/s41467-021-20918-w
Nature Communications 12 (2021) 1
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Jones, G, Trajanoska, K, Santanasto, A J, Stringa, N, Kuo, C-L, Atkins, J L, Lewis, J R, Duong, T, Hong, S, Biggs, M L, Luan, J, Sarnowski, C, Lunetta, K L, Tanaka, T, Wojczynski, M K, Cvejkus, R, Nethander, M, Ghasemi, S, Yang, J, Zillikens, M C, Walter, S, Sicinski, K, Kague, E, Ackert-Bicknell, C L, Arking, D E, Windham, B G, Boerwinkle, E, Grove, M L, Graff, M, Spira, D, Demuth, I, van der Velde, N, de Groot, L C P G M, Psaty, B M, Odden, M C, Fohner, A E, Langenberg, C, Wareham, N J, Bandinelli, S, van Schoor, N M, Huisman, M, Tan, Q, Zmuda, J, Mellström, D, Karlsson, M, Bennett, D A, Buchman, A S, De Jager, P L, Uitterlinden, A G, Völker, U, Kocher, T, Teumer, A, Rodriguéz-Mañas, L, García, F J, Carnicero, J A, Herd, P, Bertram, L, Ohlsson, C, Murabito, J M, Melzer, D, Kuchel, G A, Ferrucci, L, Karasik, D, Rivadeneira, F, Kiel, D P & Pilling, L C 2021, ' Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women ', Nature Communications, vol. 12, no. 1, 654 . https://doi.org/10.1038/s41467-021-20918-w
Nature Communications
Nature Communications, 12(1):654. Nature Publishing Group
Nature Communications, 12(1):654
Nature communications, 12(1):654. Nature Publishing Group
Jones, G, Trajanoska, K, Santanasto, A J, Stringa, N, Kuo, C-L, Atkins, J L, Lewis, J R, Duong, T, Hong, S, Biggs, M L, Luan, J, Sarnowski, C, Lunetta, K L, Tanaka, T, Wojczynski, M K, Cvejkus, R, Nethander, M, Ghasemi, S, Yang, J, Zillikens, M C, Walter, S, Sicinski, K, Kague, E, Ackert-Bicknell, C L, Arking, D E, Windham, B G, Boerwinkle, E, Grove, M L, Graff, M, Spira, D, Demuth, I, van der Velde, N, de Groot, L C P G M, Psaty, B M, Odden, M C, Fohner, A E, Langenberg, C, Wareham, N J, Bandinelli, S, van Schoor, N M, Huisman, M, Tan, Q, Zmuda, J, Mellström, D, Karlsson, M, Bennett, D A, Buchman, A S, de Jager, P L, Uitterlinden, A G, Völker, U, Kocher, T, Teumer, A, Rodriguéz-Mañas, L, García, F J, Carnicero, J A, Herd, P, Bertram, L, Ohlsson, C, Murabito, J M, Melzer, D, Kuchel, G A, Ferrucci, L, Karasik, D, Rivadeneira, F, Kiel, D P & Pilling, L C 2021, ' Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women ', Nature Communications, vol. 12, no. 1, 654 . https://doi.org/10.1038/s41467-021-20918-w
Nature Communications 12 (2021) 1
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and over from 22 cohorts we identify 15 loci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79748cf7d7c0a6c4d2ca7358a74d195d
https://www.repository.cam.ac.uk/handle/1810/316826
https://www.repository.cam.ac.uk/handle/1810/316826