Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jae J. Song"'
Publikováno v:
Apoptosis. 21:351-364
In this study, we demonstrated that survivin downregulation with TRAIL expression greatly enhanced the cytotoxic death of pancreatic cancer cells after gemcitabine treatment. Using real-time RT-PCR, we analyzed five survivin shRNAs to identify the be
Autor:
Hye Jin Choi, Suyeon Je, So Young Kim, Dongxu Kang, Jae J. Song, Yong sic Hwang, Zhezhu Han, Joo Hang Kim, Sujin Kang
Publikováno v:
Cellular signalling. 27(4)
Gemcitabine has been used most commonly as an anticancer drug to treat advanced pancreatic cancer patients. However, intrinsic or acquired resistance of pancreatic cancer to gemcitabine was also developed, which leads to very low five-year survival r
Publikováno v:
Cancer Immunology Research. 5:B81-B81
As combining therapeutic agents with different action mechanisms may enhance efficacy, YSC-02, an oncolytic adenovirus with multi targets was loaded with five different genes, which were designed with the expectation that different action mechanisms
Publikováno v:
Yonsei Medical Journal
Purpose Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism in the resista
Autor:
Dongxu Kang, Hye Jin Choi, Eun Kyung Kim, So Y. Kim, Seungha Lee, Jae J. Song, Sujin Kang, Joo Hang Kim
Publikováno v:
Cancer Research. 74:694-694
Gemcitabine as the standard chemotherapy agent to pancreatic cancer has proved effective; however, the response rate remains at 5.4% and the 5-year survival rate is extremely poor. Due to the shortcomings of gemcitabine and the presence of gemcitabin
Autor:
Joo Hang Kim, Eun Ah Cho, Jae J. Song, Eun Hee Kim, Dae Bong Kang, Chae O K Yun, Joohyuk Sohn
Publikováno v:
Human gene therapy. 14(17)
Recombinant adenovirus (Ad) has emerged as the vector system of choice in cancer gene therapy. Its full utility, however, has been limited because of the low efficiency of adenovirus-mediated gene transfer to cancer cells - the main reason being that
Publikováno v:
Molecular Cancer Therapeutics. 12:C237-C237
Although the combination of gemcitabine with a variety of cytotoxic and targeted agents has generally shown no significant survival advantage as compared with gemcitabine alone, still, many targeted agents against various pathways remain to be tested
Publikováno v:
Cancer Research. 73:2957-2957
TRAIL-induced activation of Akt catalytic activity and phosphorylation were highly correlated with p38/HSP27 phosphorylation, whereas the phosphorylation of p38/HSP27 increased further during incubation with curcumin and TRAIL, which caused significa
Autor:
Sun Min Lim, Byoung Chul Cho, Hyo Sup Shim, Hye Ryun Kim, Soo Youl Kim, Joo Hang Kim, Jae Heon Jeong, Kyung Young Chung, Se Kyu Kim, S. M. Bakhtiar Ul Islam, Jae J. Song
Publikováno v:
Journal of Korean Medical Science
Transglutaminase 2 (TG2), a cross-linking enzyme, is involved in drug resistance and in the constitutive activation of nuclear factor kappa B (NF-κB). We investigated the association of non-small cell lung cancer (NSCLC) treatment efficacy with TG2
Publikováno v:
Cancer Research. 71:4104-4104
Previously, we demonstrated that TRAIL-induced p38 activation was responsible for the increases of Akt catalytic and invasive activity. Interestingly, TRAIL induced dramatically Akt catalytic activation in TRAIL-sensitive cells, whereas TRAIL did not