Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Goro Katsuumi"'
Autor:
Ippei Shimizu, Takuya Ozawa, Yohko Yoshida, Goro Katsuumi, Tomoyoshi Soga, Daisuke Izumi, Y Hsiao, Masaaki Nakao, Tohru Minamino, Takayuki Wakasugi, Masayoshi Suda, Yuka Hayashi, Kazuyuki Ozaki, Ryutaro Ikegami, Takeshi Kashimura
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Prognosis of severe heart failure remains poor. Urgent new therapies are required. Some heart failure patients do not respond to established multidisciplinary treatment and are classified as “non-responders”. The outcome is especially poor for no
Autor:
Ippei Shimizu, Yusuke Ota, Sho Okada, Ayako Nagasawa, Masayoshi Suda, Goro Katsuumi, Marcus Fruttiger, Yoshiaki Kubota, Takayuki Wakasugi, Tohru Minamino, Masataka Yokoyama, Ryutaro Ikegami, Masanori Tsuchida, Yuka Hayashi, Yoshio Kobayashi, Yohko Yoshida
Publikováno v:
Journal of Molecular and Cellular Cardiology. 129:105-117
p53 is a guardian of the genome that protects against carcinogenesis. There is accumulating evidence that p53 is activated with aging. Such activation has been reported to contribute to various age-associated pathologies, but its role in vascular dys
Autor:
Ryo Furuuchi, Goro Katsuumi, Ippei Shimizu, Masaaki Nakao, Yuka Hayashi, Masayoshi Suda, Yohko Yoshida, Tohru Minamino, Yang-Ting Hsiao
Publikováno v:
Circulation. 142
Introduction: Recent studies have shown elimination of senescent cells, so-called "senolysis" has the potential to become a novel therapy for aging and age-related disorders. However, there is no senolytic drug available in clinical settings currentl
Autor:
Ippei Shimizu, Yuka Hayashi, Goro Katsuumi, Masayoshi Suda, Ryutaro Ikegami, Y Hsiao, Yohko Yoshida, Masaaki Nakao, Y Tsukano, Tohru Minamino
Publikováno v:
European Heart Journal. 41
Chronic sterile inflammation in visceral fat has causal roles for systemic metabolic disorders in obesity. Inflamed visceral adipose tissue secretes pro-inflammatory adipokines, and this contributes to tissue remodeling under a metabolically stressed
Autor:
Masayoshi Suda, Y Hsiao, Ippei Shimizu, Tohru Minamino, Takayuki Wakasugi, Yuka Hayashi, Ryutaro Ikegami, Goro Katsuumi, Masaaki Nakao, Yohko Yoshida
Publikováno v:
European Heart Journal. 41
Background/Introduction Non-alcoholic steatohepatitis (NASH), driven by the obesity epidemic, has become the most common form of liver disease. Inflamed visceral adipose tissue secretes pro-inflammatory adipokines that are causal for systemic metabol
Autor:
Ryo Furuuchi, Masayoshi Suda, Yuka Hayashi, Masaaki Nakao, Ippei Shimizu, Tohru Minamino, Y Hsiao, Yohko Yoshida, Goro Katsuumi
Publikováno v:
European Heart Journal. 41
Background Cellular senescence occurs as a result of various genotoxic stresses and it plays a pivotal role in aging and age-related disorders. Recently, it was shown that elimination of senescent cells, so-called “senolysis” has the potential to
Autor:
Goro Katsuumi, Ippei Shimizu, Shinya Fujiki, Tohru Minamino, Yuka Hayashi, Masayoshi Suda, Yohko Yoshida
Publikováno v:
European Heart Journal. 41
The prevalence of obesity is increasing worldwide. Obese individuals are predisposed to cardio-metabolic disorders. Brown adipose tissue (BAT) is an active metabolic organ abundant with mitochondria, and studies suggest a potential role of BAT in the
Autor:
Ippei Shimizu, Masaaki Nakao, Yuka Hayashi, Goro Katsuumi, Yohko Yoshida, Takayuki Wakasugi, Tohru Minamino, Ryutaro Ikegami, Masayoshi Suda
Publikováno v:
International Heart Journal. 59:837-844
Previous studies have suggested that cellular senescence plays a central role in the progression of pathologic changes in the failing heart. It is well known that the sympathetic nervous system is activated in patients with heart failure, and this ch
Autor:
Tohru Minamino, Ippei Shimizu, Masaaki Nakao, Ryutaro Ikegami, Masayoshi Suda, Takayuki Wakasugi, Yohko Yoshida, Yuka Hayashi, Goro Katsuumi
Publikováno v:
European Heart Journal. 40
Background Empagliflozin is a renal sodium glucose transporter 2 (SGLT2) inhibitor, thereby mediates its anti-diabetic effect via excretion of glucose into urine. EMPA-REG OUTCOME study, the first big randomized control trial of empagliflozin have sh
Autor:
Yohko Yoshida, Shinya Fujiki, Ryutaro Ikegami, Goro Katsuumi, Yuka Hayashi, Tohru Minamino, Masayoshi Suda, Ippei Shimizu
Publikováno v:
European Heart Journal. 40
Obese individuals are predisposed to cardio-metabolic disorders. Brown adipose tissue (BAT) is an active metabolic organ abundant with mitochondria, and studies suggest a potential role of BAT in the maintenance of metabolic health in rodents and hum