Zobrazeno 1 - 10
of 100
pro vyhledávání: '"David Lyden"'
Autor:
David Lyden, Laura Pisarsky, Cyrus M. Ghajar, Irina Matei, Sun-Young Lee, Serena Lucotti, Mina J. Bissell, Jinxiang Dai, Ryann E Shor
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 16, Iss 1, Pp 130-147 (2022)
Molecular Oncology, Vol 16, Iss 1, Pp 130-147 (2022)
Dormant, disseminated tumor cells (DTCs) are thought to be the source of breast cancer metastases several years or even decades after initial treatment. To date, a selective therapy that leads to their elimination has not been discovered. While dorma
Autor:
Neal Rosen, Kathryn C. Arbour, David Lyden, Valerie W. Rusch, Bob T. Li, Gaetano Rocco, Gregory J. Riely, Prasad S. Adusumilli, Brooke Mastrogiacomo, Raul Caso, Sandra Misale, Rona Yaeger, Alexander Drilon, Smita Sihag, Matthew J. Bott, Piro Lito, James G. Connolly, Yuan Liu, Yonina R. Murciano-Goroff, Kay See Tan, David R. Jones, Daniela Molena, Gregory D. Jones, James M. Isbell, Francisco Sanchez-Vega, Haiying Zhang, Charles M. Rudin
Publikováno v:
Clin Cancer Res
Purpose: KRAS G12C is the most common KRAS mutation in primary lung adenocarcinoma. Phase I clinical trials have demonstrated encouraging clinical activity of KRASG12C inhibitors in the metastatic setting. We investigated disease-free survival (DFS)
Autor:
Alberto Benito-Martin, David Lyden, Laura Nogués, Cristina Merino, Mitchell P. Levesque, Anna Szumera-Ciećkiewicz, Manuel Pérez-Martínez, Javier Munoz, Jasminka Boskovic, Ana Amor López, Irina Matei, Iwona Kalinowska, Lola Martínez, Carmen García-Martín, Babak J. Mehrara, Julia M. Martinez-Gomez, Vanesa Santos, Sagrario Ortega, Sara Sánchez-Redondo, Andrés Hidalgo, Diego Megías, Marina S. Mazariegos, José Ángel Nicolás-Ávila, Annalisa Saltari, Susana García-Silva, Sandra Rodriguez-Perales, Raúl Torres-Ruiz, Sabrina A. Hogan, Héctor Peinado, H. Uri Saragovi, Alberto Hernández-Barranco, Gadea Mata, Piotr Rutkowski, Pilar Ximénez-Embún, Raghu P. Kataru, Marta Hergueta-Redondo, Osvaldo Graña-Castro
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Instituto de Salud Carlos III (ISCIII)
Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph node pre-metastatic niche formation in murine models. We found that small EVs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f99d2141493e552b93a4b7139e2c246
https://hdl.handle.net/20.500.12105/13494
https://hdl.handle.net/20.500.12105/13494
Publikováno v:
Nature Cell Biology. 23:111-113
Anorexia commonly develops in patients with advanced cancer and is closely associated with cachexia. A new study shows that anorexia emerges earlier than cachexia in both Drosophila and mouse tumour models and that tumour-derived humoral factors indu
Autor:
Etienne Meylan, David R. Jones, Navneet Narula, Jinxiang Dai, Shahin Rafii, Yuan Liu, Henrik Molina, Irene Casanova-Salas, Han Sang Kim, Irina Matei, David J. Pisapia, Alberto Benito-Martin, Quincey LaPlant, Joshua K. Sabari, Milica Tesic Mark, David Lyden, Candia M. Kenific, Daniela Freitas, Sandra J. Shin, Xinran Jiang, Nasser K. Altorki, Yonathan Ararso, Katharine Offer, Paula S. Ginter, Brian D. Dill, Loïc Steiner, Vinagolu K. Rajasekhar, Brunilde Gril, Huajuan Wang, Maria de Sousa, Gonçalo Rodrigues, Chaitanya R. Badwe, Héctor Peinado, Shizhen Emily Wang, Tyler M. Lu, Bruno Costa-Silva, Haiying Zhang, Patricia S. Steeg, Cyrus M. Ghajar, Ayuko Hoshino, Weston Buehring, John H. Healey, Charles M. Rudin, Peter R. Oxley, Linda Bojmar, Ilana Scandariato, Jacqueline Bromberg
Publikováno v:
Nature cell biology, vol 21, iss 11
Nat Cell Biol
Nat Cell Biol
The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic coloniz
Autor:
Qing Chang, M. Turkekul, E. Spisni, Brian Houck-Loomis, Chiara Mastroleo, F. Borsetti, Fresia Pareja, David Lyden, Marjan Berishaj, M.F. Berger, Bo Liu, David N Brown, R. Segu Rajappachetty, Fanli Meng, Alexander V Penson, Jorge S. Reis-Filho, S Chandarlapaty, Jacqueline Bromberg, Pasquale Sansone, V. Boyko, A. Strillacci, E. De Stanchina, Ronald C. Hendrickson, V. R. Rajasekhar
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is a widely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e53ecd1890b10adf42b0f673f833a772
https://doi.org/10.1101/2021.10.14.464262
https://doi.org/10.1101/2021.10.14.464262
Autor:
John A. Porco, Subhiksha Nandakumar, Nicolas Lecomte, Talia Golan, Lee Shaashua, Ruth Scherz-Shouval, David A. Tuveson, Ephrat Levy-Lahad, Nikolaus Schultz, Roni Stok, Christine A. Iacobuzio-Donahue, David P. Kelsen, Rawand Hamodi, Yaniv Stein, Meirav Pevsner-Fischer, Han Sang Kim, Reinat Nevo, Wenhan Zhang, Oshrat Levi-Galibov, Lauren E. Brown, Hend Bishara, David Lyden, Gil Friedman, Linda Bojmar, William R. Jarnagin
Cancer-associated fibroblasts (CAFs) give rise to desmoplastic stroma, which supports tumor progression and metastasis, and comprises up to 90% of the tumor mass in pancreatic cancer. Recent work by us and others has shown that CAFs are transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a64ddd99bbe453bfeffb2e5d804598e9
https://doi.org/10.1101/2021.08.18.456576
https://doi.org/10.1101/2021.08.18.456576
Autor:
Laura Pisarsky, Serena Lucotti, Cyrus M. Ghajar, Jinxiang Dai, Sun-Young Lee, Irina Matei, David Lyden, Ryann E Shor, Mina J. Bissell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e97db98951db49dcb38af28232e31b83
https://doi.org/10.1002/1878-0261.13031/v2/response1
https://doi.org/10.1002/1878-0261.13031/v2/response1
Publikováno v:
Developmental Cell. 49:347-360
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and t
Autor:
Marc Ladanyi, William D. Travis, Matthew J. Bott, David Lyden, Yuan Liu, Axel Martin, Nikolaus Schultz, Kay See Tan, Prasad S. Adusumilli, Michael F. Berger, Gregory J Riely, Francisco Sanchez-Vega, Gaetano Rocco, David R. Jones, Whitney S. Brandt, Jamie E. Chaft, Marcin Imielinski, Bob T. Li, Daniela Molena, Ronglai Shen, Bernard J. Park, Ariana Adamski, David B. Solit, Marty W. Mayo, Natasha Rekhtman, Gregory D. Jones, Jian Zhou, Hira Rizvi
Publikováno v:
JAMA Surg
IMPORTANCE: Recommendations for adjuvant therapy after surgical resection of lung adenocarcinoma (LUAD) are based solely on TNM classification but are agnostic to genomic and high-risk clinicopathologic factors. Creation of a prediction model that in