Zobrazeno 51 - 60
of 100
pro vyhledávání: '"David Lyden"'
Autor:
Katherine M. Offer, Stephen C. Searles, Candia M. Kenific, David Lyden, Jack D. Bui, Ayuko Hoshino, Miho Nakajima
Publikováno v:
Cancer Research. 77:4805-4805
Among pediatric cancers, sarcomas, especially those with large tumor burdens and metastatic disease, often result in poor outcome. Thus, new treatments are urgently needed to inhibit tumor progression, prevent metastasis, and improve overall survival
Autor:
Kevin C. De Braganca, Jill M. Kolesar, Yasmin Khakoo, Tanya M. Trippett, Kim Kramer, Shakeel Modak, Stephen Gilheeney, Brian H. Kushner, Oren J. Becher, Jason T. Huse, Nai-Kong V. Cheung, David Lyden, Nathan E. Millard, Sofia Haque, Ira J. Dunkel, Ivan Spasojevic
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178593 (2017)
PLoS ONE
PLoS ONE
The PI3K/Akt/mTOR signaling pathway is aberrantly activated in various pediatric tumors. We conducted a phase I study of the Akt inhibitor perifosine in patients with recurrent/refractory pediatric CNS and solid tumors. This was a standard 3+3 open-l
Autor:
Caitlin Williams, Kavita Mallya, Saya H. Ebbesen, Gonçalo Rodrigues, Henrik Molina, Irina Matei, Ayuko Hoshino, Annette Becker, William R. Jarnagin, Bruno Costa-Silva, Yujie Huang, Milica Tesic Mark, Inger Marie Bowitz Lothe, Nicole M. Aiello, Michael A. Hollingsworth, Tang-Long Shen, Guillermo García-Santos, Till Martin Theilen, Elin H. Kure, Yonathan Ararso, Haiying Zhang, Robert E. Schwartz, Alexandre Doussot, Allyson J. Ocean, Basant Kumar Thakur, Jonathan M. Hernandez, Knut Jørgen Labori, Paul M. Grandgenett, David Lyden, Ben Z. Stanger, Swarnima Singh, Maneesh Jain, Jenny Xiang, Tuo Zhang, Héctor Peinado, Jacqueline Bromberg, Surinder K. Batra
Publikováno v:
Nature cell biology. 17(6)
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, we show that PDAC-derived exosomes in
Autor:
David Lyden, Shankar Vallabhajosula, Betty Diamond, Angela Di Giannatale, Anastasia Nikolopoulou, Hector Peinado Selgas
Since current diagnostic tools fail to detect breast cancer (BC) metastatic spread at a very early stage, we proposed a new approach for the early detection of metastatic disease in BC patients using cancer cell derived particles known as exosomes as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4983dfe91f1e335256d956493534d3bd
https://doi.org/10.21236/ada612003
https://doi.org/10.21236/ada612003
Autor:
Basant Kumar Thakur, Haiying Zhang, Annette Becker, Irina Matei, Yujie Huang, Bruno Costa-Silva, Yan Zheng, Ayuko Hoshino, Helene Brazier, Jenny Xiang, Caitlin Williams, Ruth Rodriguez-Barrueco, Jose M Silva, Weijia Zhang, Stephen Hearn, Olivier Elemento, Navid Paknejad, Katia Manova-Todorova, Karl Welte, Jacqueline Bromberg, Héctor Peinado, David Lyden
Publikováno v:
Cell Research
The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recoverin
Autor:
Stephen Gilheeney, Jason T. Huse, Shakeel Modak, Jill M. Kolesar, David Lyden, Ira J. Dunkel, Kim Kramer, Ivan Spasojevic, Oren J. Becher, Kevin C. De Braganca, Yasmin Khakoo, Sofia Haque, Leonard H. Wexler
Publikováno v:
Pediatric Blood & Cancer. 64:e26409
Background The PI3K/AKT/mTOR pathway is aberrantly activated in many pediatric solid tumors including gliomas and medulloblastomas. Preclinical data in a pediatric glioma model demonstrated that the combination of perifosine (AKT inhibitor) and temsi
Autor:
David Lyden, Jedd D. Wolchok, Rosandra N. Kaplan, Paul B. Chapman, Mary S. Brady, Guillermo García-Santos, Irina Matei, Caitlin Williams, Yibin Kang, Simon Lavotshkin, Johan Skog, Benjamin A. Garcia, Jacqueline Bromberg, Héctor Peinado, Bruno Costa-Silva, Margaret K. Callahan, Ayuko Nitadori-Hoshino, Marta Hergueta-Redondo, Caitlin Hoffman, Vilma R. Martins, Jianda Yuan, Cyrus M. Ghajar, Karen Badal, Gema Moreno-Bueno, Maša Alecˇković
Publikováno v:
Nature Medicine. 22:1502-1502
Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Autor:
Xuri Li, David Lyden, Joon Hyung Kim, Jacqueline Bromberg, Zhongshu Tang, Yujie Huang, Jeffrey P. Greenfield, Prajwal Rajappa, Jason T. Huse, Caitlin Hoffman, Babette B. Weksler, Wenhuo Hu
Publikováno v:
Cancer research. 74(4)
Enhanced platelet-derived growth factor (PDGF) signaling in glioma drives its development and progression. In this study, we define a unique role for stroma-derived PDGF signaling in maintaining tumor homeostasis within the glioma microenvironment. L
Publikováno v:
Nature medicine, vol 19, iss 9
Promising advances in cancer therapy stemming from an increasing understanding of the molecular and genetic underpinnings of the tumorigenic process have been fueled by a strong, determined scientific community, influential patient advocacy groups an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd18be7d515101dd361823d1a9bdb3bc
https://escholarship.org/uc/item/3pg12525
https://escholarship.org/uc/item/3pg12525
Publikováno v:
Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication ISBN: 9781461436966
Exosomes and microvesicles are small spherical membrane fragments shed by several cell types during physiological processes. Increasing attention has been focused on the role of exosomes in malignant progression and metastasis. This chapter highlight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf1ef26aa712d91b6bda7d40a9001e4
https://doi.org/10.1007/978-1-4614-3697-3_9
https://doi.org/10.1007/978-1-4614-3697-3_9