Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Christoffels, A."'
Autor:
Junaid Gamieldien, Hocine Bendou, Alan Christoffels, Abdulazeez Giwa, Sophia Catherine Rossouw, Azeez Fatai
Publikováno v:
Future Oncology. 17:4769-4783
Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were stratified into
Autor:
Mary N. Sheppard, Allard C. van der Wal, Steffen E. Petersen, Vincent M. Christoffels, Bram F. Coolen, Hanne C. E. Riekerk, Gustav J. Strijkers, Roelof-Jan Oostra, Bjarke Jensen
Publikováno v:
Journal of Anatomy
Journal of anatomy, 240(2), 357-375. Wiley-Blackwell
Journal of anatomy, 240(2), 357-375. Wiley-Blackwell
The ventricular walls of the human heart comprise an outer compact layer and an inner trabecular layer. In the context of an increased pre‐test probability, diagnosis left ventricular noncompaction cardiomyopathy is given when the left ventricle is
Publikováno v:
Oncotarget
Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic signature from gene express
Autor:
Bjarke Jensen, Vincent M. Christoffels, William Joyce, David Sedmera, Martina Gregorovicova, Tobias Wang
Publikováno v:
Evolution and Development. Wiley-Blackwell Publishing Ltd
Jensen, B, Joyce, W, Gregorovicova, M, Sedmera, D, Wang, T & Christoffels, V M 2020, ' Low incidence of atrial septal defects in nonmammalian vertebrates ', Evolution & Development, vol. 22, no. 3, pp. 241-256 . https://doi.org/10.1111/ede.12322
Jensen, B, Joyce, W, Gregorovicova, M, Sedmera, D, Wang, T & Christoffels, V M 2020, ' Low incidence of atrial septal defects in nonmammalian vertebrates ', Evolution & Development, vol. 22, no. 3, pp. 241-256 . https://doi.org/10.1111/ede.12322
The atrial septum enables efficient oxygen transport by separating the systemic and pulmonary venous blood returning to the heart. Only in placental mammals will the atrial septum form by the coming-together of the septum primum and the septum secund
Autor:
Doris Škorić-Milosavljević, Najim Lahrouchi, Fernanda M. Bosada, Gregor Dombrowsky, Simon G. Williams, Robert Lesurf, Fleur V.Y. Tjong, Roddy Walsh, Ihssane El Bouchikhi, Jeroen Breckpot, Enrique Audain, Aho Ilgun, Leander Beekman, Ilham Ratbi, Alanna Strong, Maximilian Muenke, Solveig Heide, Alison M. Muir, Mariam Hababa, Laura Cross, Dihong Zhou, Tomi Pastinen, Marc-Phillip Hitz, Hashim Abdul-Khaliq, Felix Berger, Ingo Dähnert, Sven Dittrich, Anselm Uebing, Brigitte Stiller, Elaine Zackai, Samir Atmani, Karim Ouldim, Najlae Adadi, Katharina Steindl, Anita Rauch, David Brook, Anna Wilsdon, Irene Kuipers, Nico A. Blom, Barbara J. Mulder, Heather C. Mefford, Boris Keren, Pascal Joset, Paul Kruszka, Isabelle Thiffault, Sarah E. Sheppard, Amy Roberts, Elisabeth M. Lodder, Bernard D. Keavney, Sally-Ann B. Clur, Seema Mital, Marc-Philip Hitz, Vincent M. Christoffels, Alex V. Postma, Connie R. Bezzina
Publikováno v:
Genetics in Medicine
Genetics in medicine, 23(10), 1952-1960. Lippincott Williams and Wilkins
Genetics in Medicine, 23(10), 1952-1960. SPRINGERNATURE
Škorić-Milosavljević, D, Lahrouchi, N, Bosada, FM, Dombrowsky, G, Williams, SG, Lesurf, R, Tjong, FVY, Walsh, R, El, B I, Breckpot, J, Audain, E, Bezzina, CR & Keavney, B 2021, ' Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot. ', Genetics in medicine : official journal of the American College of Medical Genetics . https://doi.org/10.1038/s41436-021-01212-y
Genetics in medicine, 23(10), 1952-1960. Lippincott Williams and Wilkins
Genetics in Medicine, 23(10), 1952-1960. SPRINGERNATURE
Škorić-Milosavljević, D, Lahrouchi, N, Bosada, FM, Dombrowsky, G, Williams, SG, Lesurf, R, Tjong, FVY, Walsh, R, El, B I, Breckpot, J, Audain, E, Bezzina, CR & Keavney, B 2021, ' Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot. ', Genetics in medicine : official journal of the American College of Medical Genetics . https://doi.org/10.1038/s41436-021-01212-y
PURPOSE: Rare genetic variants in KDR, encoding the vascular endothelial growth factor receptor 2 (VEGFR2), have been reported in patients with tetralogy of Fallot (TOF). However, their role in disease causality and pathogenesis remains unclear. METH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afbca70db70b5fa002b2766fd74cae1
https://hdl.handle.net/1887/3238113
https://hdl.handle.net/1887/3238113
Autor:
Maurice J.B. van den Hoff, Marie Günthel, Vincent M. Christoffels, Jorn Jeremiasse, Karel van Duijvenboden
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 38, p 38 (2021)
Journal of cardiovascular development and disease, 8(4):38. MDPI AG
Journal of Cardiovascular Development and Disease
Volume 8
Issue 4
Journal of cardiovascular development and disease, 8(4):38. MDPI AG
Journal of Cardiovascular Development and Disease
Volume 8
Issue 4
Congenital heart disease (CHD) is the most common birth defect. After birth, patients with CHD may suffer from cardiac stress resulting from abnormal loading conditions. However, it is not known how this cardiac burden influences postnatal developmen
Autor:
Phil Barnett, Vincent M. Christoffels, Vincent W. W. van Eif, Arie O. Verkerk, Bastiaan J. Boukens, Joyce C K Man, Roddy Walsh, Joost A. Offerhaus, Karel van Duijvenboden, Connie R. Bezzina, Fernanda M Bosada, Koen T. Scholman
Publikováno v:
Circulation, 144(3), 229-242. Lippincott Williams and Wilkins
Background: Genetic variants in SCN10A , encoding the neuronal voltage-gated sodium channel Na V 1.8, are strongly associated with atrial fibrillation, Brugada syndrome, cardiac conduction velocities, and heart rate. The cardiac function of SCN10A ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb7cb1cc013bb5c89125cc00192a864
https://pure.amc.nl/en/publications/variant-intronic-enhancer-controls-scn10ashort-expression-and-heart-conduction(24be2388-290f-45b0-bd1e-8ab79dcd42f6).html
https://pure.amc.nl/en/publications/variant-intronic-enhancer-controls-scn10ashort-expression-and-heart-conduction(24be2388-290f-45b0-bd1e-8ab79dcd42f6).html
Autor:
Matthew E. Hurles, Danielle Posthuma, Anna Wilsdon, Alex V. Postma, Inge B. Mathijssen, Dianna M. Milewicz, Alessandra Maugeri, Quinten Waisfisz, Aho Ilgun, Jeanne E. Savage, Marc Philip Hitz, Iris E. Jansen, Enrique Audain Martinez, Frances A. Bu'Lock, Felix Berger, Vincent M. Christoffels, Ahmed S. Amin, Rob Zwart, Maša Umićević Mirkov, Gregor Dombrowsky, Hanne Meijers-Heijboer, Eva S. van Walree, Allard C. van der Wal, S. A. Clur, Sven Dittrich, Dongchuan Guo
Publikováno v:
van Walree, E S, Dombrowsky, G, Jansen, I E, Umićević Mirkov, M, Zwart, R, Ilgun, A, Guo, D, Clur, S-A B, Amin, A S, Savage, J E, van der Wal, A C, Waisfisz, Q, Maugeri, A, Wilsdon, A, Bu'Lock, F A, Hurles, M E, Dittrich, S, Berger, F, Audain Martinez, E, Christoffels, V M, Hitz, M-P, Milewicz, D M, Posthuma, D, Meijers-Heijboer, H, Postma, A V & Mathijssen, I B 2022, ' Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms ', Genetics in Medicine, vol. 24, no. 4, pp. 965-965 . https://doi.org/10.1016/j.gim.2022.01.018
van Walree, E S, Dombrowsky, G, Jansen, I E, Mirkov, M U, Zwart, R, Ilgun, A, Guo, D, Clur, S-A B, Amin, A S, Savage, J E, van der Wal, A C, Waisfisz, Q, Maugeri, A, Wilsdon, A, Bu’Lock, F A, Hurles, M E, Dittrich, S, Berger, F, Audain Martinez, E, Christoffels, V M, Hitz, M-P, Milewicz, D M, Posthuma, D, Meijers-Heijboer, H, Postma, A V & Mathijssen, I B 2021, ' Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms ', Genetics in Medicine, vol. 23, no. 1, pp. 103-110 . https://doi.org/10.1038/s41436-020-00939-4
Genetics in Medicine, 24(4), 965-965. Lippincott Williams and Wilkins
Genetics in medicine, 23(1), 103-110. Lippincott Williams and Wilkins
Genetics in medicine : official journal of the American College of Medical Genetics
Genetics in Medicine, 23(1), 103-110. Lippincott Williams and Wilkins
van Walree, E S, Dombrowsky, G, Jansen, I E, Mirkov, M U, Zwart, R, Ilgun, A, Guo, D, Clur, S A B, Amin, A S, Savage, J E, van der Wal, A C, Waisfisz, Q, Maugeri, A, Wilsdon, A, Bu’Lock, F A, Hurles, M E, Dittrich, S, Berger, F, Audain Martinez, E, Christoffels, V M, Hitz, M P, Milewicz, D M, Posthuma, D, Meijers-Heijboer, H, Postma, A V & Mathijssen, I B 2021, ' Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms ', Genetics in Medicine, vol. 23, no. 1, pp. 103-110 . https://doi.org/10.1038/s41436-020-00939-4
van Walree, E S, Dombrowsky, G, Jansen, I E, Mirkov, M U, Zwart, R, Ilgun, A, Guo, D, Clur, S-A B, Amin, A S, Savage, J E, van der Wal, A C, Waisfisz, Q, Maugeri, A, Wilsdon, A, Bu’Lock, F A, Hurles, M E, Dittrich, S, Berger, F, Audain Martinez, E, Christoffels, V M, Hitz, M-P, Milewicz, D M, Posthuma, D, Meijers-Heijboer, H, Postma, A V & Mathijssen, I B 2021, ' Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms ', Genetics in Medicine, vol. 23, no. 1, pp. 103-110 . https://doi.org/10.1038/s41436-020-00939-4
Genetics in Medicine, 24(4), 965-965. Lippincott Williams and Wilkins
Genetics in medicine, 23(1), 103-110. Lippincott Williams and Wilkins
Genetics in medicine : official journal of the American College of Medical Genetics
Genetics in Medicine, 23(1), 103-110. Lippincott Williams and Wilkins
van Walree, E S, Dombrowsky, G, Jansen, I E, Mirkov, M U, Zwart, R, Ilgun, A, Guo, D, Clur, S A B, Amin, A S, Savage, J E, van der Wal, A C, Waisfisz, Q, Maugeri, A, Wilsdon, A, Bu’Lock, F A, Hurles, M E, Dittrich, S, Berger, F, Audain Martinez, E, Christoffels, V M, Hitz, M P, Milewicz, D M, Posthuma, D, Meijers-Heijboer, H, Postma, A V & Mathijssen, I B 2021, ' Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms ', Genetics in Medicine, vol. 23, no. 1, pp. 103-110 . https://doi.org/10.1038/s41436-020-00939-4
Purpose: In this study we aimed to establish the genetic cause of a myriad of cardiovascular defects prevalent in individuals from a genetically isolated population, who were found to share a common ancestor in 1728. Methods: Trio genome sequencing w
Autor:
Vincent M. Christoffels, Cindy P. A. A. van Roomen, Esther E. Creemers, Ingeborg B. Hooijkaas, Hylja Heese, Lejla Medzikovic, Vivian de Waard, Pieter B. van Loenen, Carlie J.M. de Vries
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1600, p 1600 (2021)
International journal of molecular sciences, 22(4):1600, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 4
International journal of molecular sciences, 22(4):1600, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 4
Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is also an essential repair mechanism to prevent cardiac rupture, signifying the importance of appropriate regulation of this process. In the remodeling heart,
Autor:
Quint A. J. Hagdorn, Rolf M. F. Berger, Guido P. L. Bossers, Anne-Marie C. Koop, Karel van Duijvenboden, Marie Günthel Dipl-Ing, Marinus A.J. Borgdorff, Vincent M. Christoffels, Herman H W Silljé, Phil Barnett, Beatrijs Bartelds, Diederik E. van der Feen
Publikováno v:
Journal of thoracic and cardiovascular surgery. Mosby Inc.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 164(6), e493-e510. MOSBY-ELSEVIER
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 164(6), e493-e510. MOSBY-ELSEVIER
OBJECTIVES: Right ventricular (RV) failure is a leading cause of death in patients with congenital heart disease. RV failure is kept at bay during childhood. Limited proliferation of cardiomyocytes is present in the postnatal heart. We propose that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b03648597bc7b1fc0cecc7e91c4a3f
https://pure.amc.nl/en/publications/neuregulin1-enhances-cellcycle-activity-delays-cardiac-fibrosis-and-improves-cardiac-performance-in-rat-pups-with-right-ventricular-pressure-load(57fcd891-8b23-48ba-bdfd-62b5017ecaa1).html
https://pure.amc.nl/en/publications/neuregulin1-enhances-cellcycle-activity-delays-cardiac-fibrosis-and-improves-cardiac-performance-in-rat-pups-with-right-ventricular-pressure-load(57fcd891-8b23-48ba-bdfd-62b5017ecaa1).html