Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Charles R. Mackay"'
Autor:
Juliana Echevarria-Lima, Leandro Araujo Lobo, Charles R. Mackay, Dario S. Zamboni, Robson Coutinho-Silva, Ana Carolina Oliveira, Julio Scharfstein, Regina Maria Cavalcanti Pilotto Domingues, Aline Cristina Abreu Moreira-Souza, Eliana Mariño, Erivan Schnaider Ramos-Junior, Maria Bellio, Eliane de Oliveira Ferreira, Juliana P Castelpoggi, Bruno Jennings-Almeida
Publikováno v:
The Journal of Immunology. 206:2441-2452
Intestinal barrier is essential for dietary products and microbiota compartmentalization and therefore gut homeostasis. When this barrier is broken, cecal content overflows into the peritoneal cavity, leading to local and systemic robust inflammatory
Publikováno v:
Science China Life Sciences. 64:1829-1841
There is growing recognition that neutrophils play an important role in cancer initiation, progression and metastasis. Although they are typically characterized as short-lived effector cells, neutrophils have been shown to acquire immunosuppressive a
Autor:
Sara Bordbar, Charles R. Mackay, Stephen M. Twigg, Eliana Mariño, Shannon Brodie, Sonia Saad, Marc R. Wilkins, Barbara Fazekas de St Groth, Long T. Nguyen, Emma E. Hamilton-Williams, Bree J. Tillett, Susan M. Corley, Courtney J. Wright, Helen M. McGuire, Yu Anne Yap, Kirstine J. Bell, Sussan Duong, Esteban Nicolas Gurzov, Leonard C. Harrison
BackgroundShort-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteria, commonl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d99ceb0bb773c049b35a111f8cd051
https://doi.org/10.1101/2021.09.15.21263059
https://doi.org/10.1101/2021.09.15.21263059
Autor:
Melinda T. Coughlan, Waled A. Shihata, Louise M Burrell, Charles R. Mackay, Francine Z. Marques, Rikeish R. Muralitharan, Michael E Nakai, Matthew Snelson, David M. Kaye, Hamdi A. Jama, Chad Johnson, Evany Dinakis
Publikováno v:
Hypertension. 77
Autor:
Leigh Donnellan, Mark E. Cooper, Sih Min Tan, Brooke E. Harcourt, Mark Ziemann, Nicole J. Kellow, Josephine M. Forbes, Karly C. Sourris, Melinda T. Coughlan, David Steer, Rachel E. Clarke, Charles R. Mackay, Assam El-Osta, Sally A. Penfold, Tuong-Vi Nguyen, Matthew Snelson, Michael J. Davies, Cassandra de Pasquale, Vicki Thallas-Bonke, Runa S.J. Lindblom, Permal Deo, Trent M. Woodruff
Publikováno v:
Science Advances
Snelson, M, Tan, S M, Clarke, R E, De Pasquale, C, Thallas-Bonke, V, Nguyen, T V, Penfold, S A, Harcourt, B E, Sourris, K C, Lindblom, R S, Ziemann, M, Steer, D, El-Osta, A, Davies, M J, Donnellan, L, Deo, P, Kellow, N J, Cooper, M E, Woodruff, T M, Mackay, C R, Forbes, J M & Coughlan, M T 2021, ' Processed foods drive intestinal barrier permeability and microvascular diseases ', Science Advances, vol. 7, no. 14, eabe4841 . https://doi.org/10.1126/sciadv.abe4841
Snelson, M, Tan, S M, Clarke, R E, De Pasquale, C, Thallas-Bonke, V, Nguyen, T V, Penfold, S A, Harcourt, B E, Sourris, K C, Lindblom, R S, Ziemann, M, Steer, D, El-Osta, A, Davies, M J, Donnellan, L, Deo, P, Kellow, N J, Cooper, M E, Woodruff, T M, Mackay, C R, Forbes, J M & Coughlan, M T 2021, ' Processed foods drive intestinal barrier permeability and microvascular diseases ', Science Advances, vol. 7, no. 14, eabe4841 . https://doi.org/10.1126/sciadv.abe4841
This study shows how highly processed foods can cause innate immune inflammation that promotes chronic microvascular disease.
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular disease
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular disease
Autor:
Charles R. Mackay, Laurence Macia
Publikováno v:
Journal of Allergy and Clinical Immunology. 144:1513-1515
Autor:
Yunzi Liu, Yan J. Li, Yik W. Loh, Julian Singer, Weiping Zhu, Laurence Macia, Charles R. Mackay, Weiming Wang, Steven J. Chadban, Huiling Wu
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Short-chain fatty acids (SCFA) derived from gut microbial fermentation of fiber have been shown to exert anti-inflammatory and immune-modulatory properties in acute kidney injury (AKI). However the direct mechanistic link between SCFAs, diet and the
Autor:
Mercedes Davalos-Salas, Patrick G. Gavin, Yu Anne Yap, Jaclyn S. Pearson, Charles R. Mackay, Robert J. Moore, James L. Richards, Vik Ven Eng, Eliana Mariño, Julie M. Clarke, Trevor Lockett, Keiran H. McLeod, Emma E. Hamilton-Williams, Craig R. M. McKenzie
Publikováno v:
Clinical & Translational Immunology
Objectives During gastrointestinal infection, dysbiosis can result in decreased production of microbially derived short‐chain fatty acids (SCFAs). In response to the presence of intestinal pathogens, we examined whether an engineered acetate‐ or
Autor:
Yanjun Li, Xiaochen Chen, Yunzi Liu, Tony Kwan, Yik Wen Loh, Steven J. Chadban, Huiling Wu, Julian Singer, Laurence Macia, Jian Tan, Jin Ma, Charles R. Mackay
Publikováno v:
J Am Soc Nephrol
Background Studies have reported "dysbiotic" changes to gut microbiota, such as depletion of gut bacteria that produce short-chain fatty acids (SCFAs) through gut fermentation of fiber, in CKD and diabetes. Dietary fiber is associated with decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e509d83eb26d18d4a7b8c46ff013e92
https://europepmc.org/articles/PMC7269358/
https://europepmc.org/articles/PMC7269358/
Autor:
Charles R. Mackay, Samantha L. Dawson, Sarath Ranganathan, John Molloy, John B. Carlin, Michael A. Conlon, Karen E. Nelson, Laurence Macia, David Topping, Margarita Moreno-Betancur, Mimi L.K. Tang, Katrina J. Allen, Fiona Collier, Jennifer J. Koplin, Leonard C. Harrison, Richard Saffery, Martin O'Hely, Peter D. Sly, Angela Pezic, Peter Vuillermin, Anne-Louise Ponsonby, Lawrence E. K. Gray
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications
Nature Communications
In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus th