Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alexia Polissidis"'
Autor:
Aimilia Varela, Ioanna Kostavasili, Alexia Polissidis, Ismini Kloukina, Manolis Mavroidis, Modestos Nakos-Bimpos, Mary Tsikitis, Elsa Tsoupri, Yassemi Capetanaki, Despoina Miliou, Constantinos H. Davos, Eleni Vasilaki
Publikováno v:
Cell and Tissue Research. 385:675-696
The desmin-associated protein myospryn, encoded by the cardiomyopathy-associated gene 5 (CMYA5), is a TRIM-like protein associated to the BLOC-1 (Biogenesis of Lysosomes Related Organelles Complex 1) protein dysbindin. Human myospryn mutations are li
Autor:
Ioannis Morianos, Ioannis Charalampopoulos, Achille Gravanis, Georgina Xanthou, Katia Karalis, Yassemi Koutmani, Ioannis-Alexandros Gampierakis, Antonia Katsouda, Maria Semitekolou, Alexia Polissidis
Publikováno v:
Molecular Psychiatry. 26:1248-1263
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a disease associated with dysbiosis, resulting in compromised intestinal epithelial barrier and chronic mucosal inflammation. Patients with IBD present w
Autor:
Panagiotis K. Politis, Dimitris Stellas, George Kokotos, Alexia Polissidis, Dimitrios Gkikas, Theodora Manolakou, Maroula G. Kokotou
Publikováno v:
Proc Natl Acad Sci U S A
Nervous system malignancies are characterized by rapid progression and poor survival rates. These clinical observations underscore the need for novel therapeutic insights and pharmacological targets. To this end, here, we identify the orphan nuclear
Autor:
Pablo Sardi S, Alexia Polissidis, Nikatou M, Nikolopoulou G, Koronaiou E, K. Vekrellis, Boyongo M, Maria Xilouri, Leonidas Stefanis, Viel C
Preclinical and clinical studies support a strong association between mutations in the GBA1 gene that encodes β-glucocerebrosidase (GCase) (EC 3.2.1.45; glucosylceramidase beta) and Parkinson’s disease (PD). Alpha-synuclein (AS), a key player in P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce076a0f939294ed83a42a2b8780bd8
https://doi.org/10.1101/2021.06.23.449545
https://doi.org/10.1101/2021.06.23.449545
Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats
Autor:
Maria Koronaiou, Sergio Pablo Sardi, Marios Bogiongko, Sofia Vrettou, Maria Xilouri, Nicolas Casadei, Katerina Karali, Leonidas Stefanis, Effrosyni Koronaiou, Olaf Riess, Alexia Polissidis, Modestos Nakos-Bimpos, Vasia Kollia
Publikováno v:
Movement disorders : official journal of the Movement Disorder SocietyReferences. 36(3)
Background Parkinson's disease psychosis is a prevalent yet underreported and understudied nonmotor manifestation of Parkinson's disease and, arguably, the most debilitating. It is unknown if α-synuclein plays a role in psychosis, and if so, this en
Autor:
Leonidas Stefanis, Maria Xilouri, Oeystein Roed Brekk, Alexia Polissidis, Ismini Kloukina, Margarita Chrysanthou-Piterou
Publikováno v:
Autophagy. 12:2230-2247
Chaperone-mediated autophagy (CMA) involves the selective lysosomal degradation of cytosolic proteins such as SNCA (synuclein α), a protein strongly implicated in Parkinson disease (PD) pathogenesis. However, the physiological role of CMA and the co
Publikováno v:
Biomolecules, Vol 10, Iss 912, p 912 (2020)
Biomolecules
Biomolecules
Biomarkers and disease-modifying therapies are both urgent unmet medical needs in the treatment of Parkinson’s disease (PD) and must be developed concurrently because of their interdependent relationship: biomarkers for the early detection of disea
Autor:
Charis Liapi, Petros Karkalousos, George Dimogerontas, Alexia Polissidis, Zeta Papadopoulou-Daifoti
Publikováno v:
International Journal of Pathology and Clinical Research. 2
Objectives: Glioma, a malignant intra-axial brain tumor, can release glutamate that facilitates tumor expansion, stimulates tumor-cell proliferation and motility and promotes epileptic activity. Glutamate acid is the major excitatory neurotransmitter
Autor:
Irini Skaliora, Panagiotis Tsakanikas, Alexia Polissidis, Eleni Konsolaki, Antonios Stamatakis
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 8 (2016)
Frontiers in Aging Neuroscience, Vol 8 (2016)
In order to address pathological cognitive decline effectively, it is critical to adopt early preventive measures in individuals considered at risk. It is therefore essential to develop approaches that identify such individuals before the onset of ir
Autor:
Cornelia Poulopoulou, Z. Papadopoulou-Daifoti, Christina G. Katsiari, E. Anderzanova, Kalliopi Fragiadaki, P. Davaki, P.P. Sfikakis, Alexia Polissidis, Alex Hatzimanolis
Publikováno v:
Arthritis & Rheumatism. 58:1445-1450
Objective Alterations in glutamate homeostasis and Kv1.3 voltage-gated potassium channel function have been independently associated with T cell dysfunction, whereas selective blockade of Kv1.3 channels inhibits T cell activation and improves T cell